| 05 May 21 | r00  | Memphis RedbirdsMemphis Redbi | 5 - 7 | Durham BullsDurham Bulls |
| 06 May 21 | r00 | Memphis RedbirdsMemphis Redbi | 0 - 4 | Durham BullsDurham Bulls |
| 07 May 21 | r00 | Memphis RedbirdsMemphis Redbi | 3 - 4 | Durham BullsDurham Bulls |
| 08 May 21 | r00 | Memphis RedbirdsMemphis Redbi | 5 - 13 | Durham BullsDurham Bulls |
| 09 May 21 | r00 | Memphis RedbirdsMemphis Redbi | 3 - 15 | Durham BullsDurham Bulls |
| 09 May 21 | r00 | Memphis RedbirdsMemphis Redbi | 7 - 6 | Durham BullsDurham Bulls |
| 11 May 21 | r00 | Durham BullsDurham Bulls | 3 - 4 | Jacksonville Jumbo ShrimpJacksonville |
| 13 May 21 | r00 | Durham BullsDurham Bulls | 2 - 7 | Jacksonville Jumbo ShrimpJacksonville |
| 14 May 21 | r00 | Durham BullsDurham Bulls | 6 - 0 | Jacksonville Jumbo ShrimpJacksonville |
| 14 May 21 | r00 | Durham BullsDurham Bulls | 4 - 6 | Jacksonville Jumbo ShrimpJacksonville |
| 15 May 21 | r00 | Durham BullsDurham Bulls | 14 - 3 | Jacksonville Jumbo ShrimpJacksonville |
| 16 May 21 | r00 | Durham BullsDurham Bulls | 4 - 7 | Jacksonville Jumbo ShrimpJacksonville |
| 18 May 21 | r00 | Durham BullsDurham Bulls | 7 - 2 | Charlotte KnightsCharlotte Kni |
| 19 May 21 | r00 | Durham BullsDurham Bulls | 5 - 4 | Charlotte KnightsCharlotte Kni |
| 20 May 21 | r00 | Durham BullsDurham Bulls | 4 - 6 | Charlotte KnightsCharlotte Kni |
| 21 May 21 | r00 | Durham BullsDurham Bulls | 3 - 2 | Charlotte KnightsCharlotte Kni |
| 22 May 21 | r00 | Durham BullsDurham Bulls | 8 - 7 | Charlotte KnightsCharlotte Kni |
| 23 May 21 | r00 | Durham BullsDurham Bulls | 8 - 7 | Charlotte KnightsCharlotte Kni |
| 26 May 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 5 - 13 | Durham BullsDurham Bulls |
| 27 May 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 0 - 3 | Durham BullsDurham Bulls |
| 28 May 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 0 - 5 | Durham BullsDurham Bulls |
| 29 May 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 1 - 9 | Durham BullsDurham Bulls |
| 29 May 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 1 - 8 | Durham BullsDurham Bulls |
| 30 May 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 5 - 0 | Durham BullsDurham Bulls |
| 01 Jun 21 | r00 | Durham BullsDurham Bulls | 5 - 6 | Norfolk TidesNorfolk Tides |
| 02 Jun 21 | r00 | Durham BullsDurham Bulls | 11 - 2 | Norfolk TidesNorfolk Tides |
| 03 Jun 21 | r00 | Durham BullsDurham Bulls | 4 - 12 | Norfolk TidesNorfolk Tides |
| 05 Jun 21 | r00 | Durham BullsDurham Bulls | 4 - 0 | Norfolk TidesNorfolk Tides |
| 06 Jun 21 | r00 | Durham BullsDurham Bulls | 4 - 3 | Norfolk TidesNorfolk Tides |
| 08 Jun 21 | r00 | Durham BullsDurham Bulls | 8 - 5 | Charlotte KnightsCharlotte Kni |
| 09 Jun 21 | r00 | Durham BullsDurham Bulls | 10 - 5 | Charlotte KnightsCharlotte Kni |
| 10 Jun 21 | r00 | Durham BullsDurham Bulls | 3 - 2 | Charlotte KnightsCharlotte Kni |
| 11 Jun 21 | r00 | Durham BullsDurham Bulls | 4 - 5 | Charlotte KnightsCharlotte Kni |
| 12 Jun 21 | r00 | Durham BullsDurham Bulls | 11 - 0 | Charlotte KnightsCharlotte Kni |
| 13 Jun 21 | r00 | Durham BullsDurham Bulls | 0 - 1 | Charlotte KnightsCharlotte Kni |
| 16 Jun 21 | r00 | Norfolk TidesNorfolk Tides | 4 - 1 | Durham BullsDurham Bulls |
| 17 Jun 21 | r00 | Norfolk TidesNorfolk Tides | 5 - 7 | Durham BullsDurham Bulls |
| 17 Jun 21 | r00 | Norfolk TidesNorfolk Tides | 10 - 6 | Durham BullsDurham Bulls |
| 19 Jun 21 | r00 | Norfolk TidesNorfolk Tides | 3 - 4 | Durham BullsDurham Bulls |
| 20 Jun 21 | r00 | Norfolk TidesNorfolk Tides | 0 - 9 | Durham BullsDurham Bulls |
| 20 Jun 21 | r00 | Norfolk TidesNorfolk Tides | 5 - 6 | Durham BullsDurham Bulls |
| 23 Jun 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 1 - 4 | Durham BullsDurham Bulls |
| 24 Jun 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 3 - 1 | Durham BullsDurham Bulls |
| 25 Jun 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 4 - 3 | Durham BullsDurham Bulls |
| 26 Jun 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 1 - 5 | Durham BullsDurham Bulls |
| 26 Jun 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 3 - 4 | Durham BullsDurham Bulls |
| 27 Jun 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 3 - 2 | Durham BullsDurham Bulls |
| 29 Jun 21 | r00 | Durham BullsDurham Bulls | 8 - 3 | Gwinnett StripersGwinnett Stri |
| 30 Jun 21 | r00 | Durham BullsDurham Bulls | 1 - 2 | Gwinnett StripersGwinnett Stri |
| 01 Jul 21 | r00 | Durham BullsDurham Bulls | 6 - 1 | Gwinnett StripersGwinnett Stri |
| 02 Jul 21 | r00 | Durham BullsDurham Bulls | 9 - 7 | Gwinnett StripersGwinnett Stri |
| 03 Jul 21 | r00 | Durham BullsDurham Bulls | 6 - 5 | Gwinnett StripersGwinnett Stri |
| 04 Jul 21 | r00 | Durham BullsDurham Bulls | 5 - 4 | Gwinnett StripersGwinnett Stri |
| 07 Jul 21 | r00 | Norfolk TidesNorfolk Tides | 0 - 11 | Durham BullsDurham Bulls |
| 08 Jul 21 | r00 | Norfolk TidesNorfolk Tides | 2 - 11 | Durham BullsDurham Bulls |
| 10 Jul 21 | r00 | Norfolk TidesNorfolk Tides | 9 - 4 | Durham BullsDurham Bulls |
| 11 Jul 21 | r00 | Norfolk TidesNorfolk Tides | 2 - 5 | Durham BullsDurham Bulls |
| 11 Jul 21 | r00 | Norfolk TidesNorfolk Tides | 0 - 1 | Durham BullsDurham Bulls |
| 13 Jul 21 | r00 | Durham BullsDurham Bulls | 8 - 1 | Jacksonville Jumbo ShrimpJacksonville |
| 14 Jul 21 | r00 | Durham BullsDurham Bulls | 8 - 2 | Jacksonville Jumbo ShrimpJacksonville |
| 15 Jul 21 | r00 | Durham BullsDurham Bulls | 6 - 7 | Jacksonville Jumbo ShrimpJacksonville |
| 16 Jul 21 | r00 | Durham BullsDurham Bulls | 4 - 9 | Jacksonville Jumbo ShrimpJacksonville |
| 17 Jul 21 | r00 | Durham BullsDurham Bulls | 9 - 5 | Jacksonville Jumbo ShrimpJacksonville |
| 18 Jul 21 | r00 | Durham BullsDurham Bulls | 6 - 3 | Jacksonville Jumbo ShrimpJacksonville |
| 20 Jul 21 | r00 | Durham BullsDurham Bulls | 4 - 3 | Charlotte KnightsCharlotte Kni |
| 21 Jul 21 | r00 | Durham BullsDurham Bulls | 7 - 3 | Charlotte KnightsCharlotte Kni |
| 22 Jul 21 | r00 | Durham BullsDurham Bulls | 5 - 3 | Charlotte KnightsCharlotte Kni |
| 23 Jul 21 | r00 | Durham BullsDurham Bulls | 0 - 4 | Charlotte KnightsCharlotte Kni |
| 24 Jul 21 | r00 | Durham BullsDurham Bulls | 9 - 4 | Charlotte KnightsCharlotte Kni |
| 25 Jul 21 | r00 | Durham BullsDurham Bulls | 15 - 9 | Charlotte KnightsCharlotte Kni |
| 28 Jul 21 | r00 | Norfolk TidesNorfolk Tides | 3 - 1 | Durham BullsDurham Bulls |
| 28 Jul 21 | r00 | Norfolk TidesNorfolk Tides | 4 - 3 | Durham BullsDurham Bulls |
| 29 Jul 21 | r00 | Norfolk TidesNorfolk Tides | 2 - 0 | Durham BullsDurham Bulls |
| 29 Jul 21 | r00 | Norfolk TidesNorfolk Tides | 2 - 8 | Durham BullsDurham Bulls |
| 31 Jul 21 | r00 | Norfolk TidesNorfolk Tides | 8 - 2 | Durham BullsDurham Bulls |
| 01 Aug 21 | r00 | Norfolk TidesNorfolk Tides | 6 - 12 | Durham BullsDurham Bulls |
| 01 Aug 21 | r00 | Norfolk TidesNorfolk Tides | 5 - 3 | Durham BullsDurham Bulls |
| 03 Aug 21 | r00 | Durham BullsDurham Bulls | 5 - 2 | Memphis RedbirdsMemphis Redbi |
| 04 Aug 21 | r00 | Durham BullsDurham Bulls | 3 - 6 | Memphis RedbirdsMemphis Redbi |
| 05 Aug 21 | r00 | Durham BullsDurham Bulls | 1 - 3 | Memphis RedbirdsMemphis Redbi |
| 06 Aug 21 | r00 | Durham BullsDurham Bulls | 16 - 3 | Memphis RedbirdsMemphis Redbi |
| 07 Aug 21 | r00 | Durham BullsDurham Bulls | 11 - 5 | Memphis RedbirdsMemphis Redbi |
| 08 Aug 21 | r00 | Durham BullsDurham Bulls | 3 - 3 | Memphis RedbirdsMemphis Redbi |
| 11 Aug 21 | r00 | Gwinnett StripersGwinnett Stri | 4 - 3 | Durham BullsDurham Bulls |
| 12 Aug 21 | r00 | Gwinnett StripersGwinnett Stri | 5 - 3 | Durham BullsDurham Bulls |
| 13 Aug 21 | r00 | Gwinnett StripersGwinnett Stri | 3 - 0 | Durham BullsDurham Bulls |
| 14 Aug 21 | r00 | Gwinnett StripersGwinnett Stri | 6 - 4 | Durham BullsDurham Bulls |
| 14 Aug 21 | r00 | Gwinnett StripersGwinnett Stri | 1 - 8 | Durham BullsDurham Bulls |
| 15 Aug 21 | r00 | Gwinnett StripersGwinnett Stri | 3 - 6 | Durham BullsDurham Bulls |
| 17 Aug 21 | r00 | Durham BullsDurham Bulls | 5 - 8 | Jacksonville Jumbo ShrimpJacksonville |
| 18 Aug 21 | r00 | Durham BullsDurham Bulls | 8 - 7 | Jacksonville Jumbo ShrimpJacksonville |
| 19 Aug 21 | r00 | Durham BullsDurham Bulls | 10 - 4 | Jacksonville Jumbo ShrimpJacksonville |
| 20 Aug 21 | r00 | Durham BullsDurham Bulls | 3 - 0 | Jacksonville Jumbo ShrimpJacksonville |
| 21 Aug 21 | r00 | Durham BullsDurham Bulls | 4 - 2 | Jacksonville Jumbo ShrimpJacksonville |
| 22 Aug 21 | r00 | Durham BullsDurham Bulls | 6 - 8 | Jacksonville Jumbo ShrimpJacksonville |
| 25 Aug 21 | r00 | Charlotte KnightsCharlotte Kni | 6 - 12 | Durham BullsDurham Bulls |
| 26 Aug 21 | r00 | Charlotte KnightsCharlotte Kni | 2 - 9 | Durham BullsDurham Bulls |
| 27 Aug 21 | r00 | Charlotte KnightsCharlotte Kni | 9 - 2 | Durham BullsDurham Bulls |
| 28 Aug 21 | r00 | Charlotte KnightsCharlotte Kni | 0 - 4 | Durham BullsDurham Bulls |
| 29 Aug 21 | r00 | Charlotte KnightsCharlotte Kni | 5 - 4 | Durham BullsDurham Bulls |
| 29 Aug 21 | r00 | Charlotte KnightsCharlotte Kni | 3 - 5 | Durham BullsDurham Bulls |
| 01 Sep 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 2 - 13 | Durham BullsDurham Bulls |
| 02 Sep 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 1 - 5 | Durham BullsDurham Bulls |
| 03 Sep 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 6 - 5 | Durham BullsDurham Bulls |
| 04 Sep 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 4 - 3 | Durham BullsDurham Bulls |
| 04 Sep 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 2 - 5 | Durham BullsDurham Bulls |
| 05 Sep 21 | r00 | Jacksonville Jumbo ShrimpJacksonville | 5 - 1 | Durham BullsDurham Bulls |
| 07 Sep 21 | r00 | Durham BullsDurham Bulls | 1 - 3 | Norfolk TidesNorfolk Tides |
| 08 Sep 21 | r00 | Durham BullsDurham Bulls | 9 - 3 | Norfolk TidesNorfolk Tides |
| 09 Sep 21 | r00 | Durham BullsDurham Bulls | - | Norfolk TidesNorfolk Tides |
| 10 Sep 21 | r00 | Durham BullsDurham Bulls | 10 - 1 | Norfolk TidesNorfolk Tides |
| 11 Sep 21 | r00 | Durham BullsDurham Bulls | 1 - 3 | Norfolk TidesNorfolk Tides |
| 11 Sep 21 | r00 | Durham BullsDurham Bulls | 6 - 1 | Norfolk TidesNorfolk Tides |
| 12 Sep 21 | r00 | Durham BullsDurham Bulls | 7 - 6 | Norfolk TidesNorfolk Tides |
| 15 Sep 21 | r00 | Charlotte KnightsCharlotte Kni | 2 - 6 | Durham BullsDurham Bulls |
| 16 Sep 21 | r00 | Charlotte KnightsCharlotte Kni | 1 - 2 | Durham BullsDurham Bulls |
| 17 Sep 21 | r00 | Charlotte KnightsCharlotte Kni | 6 - 8 | Durham BullsDurham Bulls |
| 18 Sep 21 | r00 | Charlotte KnightsCharlotte Kni | 5 - 4 | Durham BullsDurham Bulls |
| 19 Sep 21 | r00 | Charlotte KnightsCharlotte Kni | 5 - 9 | Durham BullsDurham Bulls |
| 19 Sep 21 | r00 | Charlotte KnightsCharlotte Kni | 4 - 9 | Durham BullsDurham Bulls |
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