| 06 Mar 23 | Qualifier     | Audax ItalianoAudax Italian | 3 - 2 | Universidad CatólicaUniversidad C |
| 06 Mar 23 | Qualifier | TacuaryTacuary | 2 - 2 | General CaballeroGeneral Cabal |
| 07 Mar 23 | Qualifier | Club Deportivo GuabiráClub Deportiv | 0 - 1 | Oriente PetroleroOriente Petro |
| 07 Mar 23 | Qualifier | Club GuaraníClub Guaraní | 3 - 1 | Sportivo AmelianoSportivo Amel |
| 07 Mar 23 | Qualifier | Defensor SportingDefensor Spor | 0 - 0 | DanubioDanubio |
| 08 Mar 23 | Qualifier | CA River PlateCA River Plat | 0 - 4 | PeñarolPeñarol |
| 08 Mar 23 | Qualifier | Caracas F.C.Caracas F.C. | 0 - 1 | Puerto Cabello F.C.Puerto Cabell |
| 08 Mar 23 | Qualifier | LDU QuitoLDU Quito | 4 - 0 | Delfin SCDelfin SC |
| 08 Mar 23 | Qualifier | BloomingBlooming | 6 - 0 | Atlético PalmaflorAtlético Palm |
| 08 Mar 23 | Qualifier | CobresalCobresal | 0 - 1 | PalestinoPalestino |
| 09 Mar 23 | Qualifier | Rionegro ÁguilasRionegro Águi | 1 - 2 | Independiente Santa FeIndependiente |
| 09 Mar 23 | Qualifier | Estudiantes de Mérida F.CEstudiantes d | 1 - 1 | Deportivo Táchira F.C.Deportivo Tác |
| 09 Mar 23 | Qualifier | Universidad César VallejoUniversidad C | 3 - 1 | EM Deportivo BinacionalEM Deportivo |
| 10 Mar 23 | Qualifier | Deportes TolimaDeportes Toli | 1 - 0 | Atlético JuniorAtlético Juni |
| 10 Mar 23 | Qualifier | EmelecEmelec | 2 - 1 | Deportivo CuencaDeportivo Cue |
| 10 Mar 23 | Qualifier | UniversitarioUniversitario | 2 - 0 | CiencianoCienciano |
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