| 06 Mar 23 | Qualifier        | Audax ItalianoAudax Italian | 3 - 2 | Universidad CatólicaUniversidad C |
| 06 Mar 23 | Qualifier        | TacuaryTacuary | 2 - 2 | General CaballeroGeneral Cabal |
| 07 Mar 23 | Qualifier        | Club Deportivo GuabiráClub Deportiv | 0 - 1 | Oriente PetroleroOriente Petro |
| 07 Mar 23 | Qualifier        | Club GuaraníClub Guaraní | 3 - 1 | Sportivo AmelianoSportivo Amel |
| 07 Mar 23 | Qualifier        | Defensor SportingDefensor Spor | 0 - 0 | DanubioDanubio |
| 08 Mar 23 | Qualifier        | CA River PlateCA River Plat | 0 - 4 | PeñarolPeñarol |
| 08 Mar 23 | Qualifier        | Caracas F.C.Caracas F.C. | 0 - 1 | Puerto Cabello F.C.Puerto Cabell |
| 08 Mar 23 | Qualifier        | LDU QuitoLDU Quito | 4 - 0 | Delfin SCDelfin SC |
| 08 Mar 23 | Qualifier        | BloomingBlooming | 6 - 0 | Atlético PalmaflorAtlético Palm |
| 08 Mar 23 | Qualifier        | CobresalCobresal | 0 - 1 | PalestinoPalestino |
| 09 Mar 23 | Qualifier        | Rionegro ÁguilasRionegro Águi | 1 - 2 | Independiente Santa FeIndependiente |
| 09 Mar 23 | Qualifier        | Estudiantes de Mérida F.CEstudiantes d | 1 - 1 | Deportivo Táchira F.C.Deportivo Tác |
| 09 Mar 23 | Qualifier        | Universidad César VallejoUniversidad C | 3 - 1 | EM Deportivo BinacionalEM Deportivo |
| 10 Mar 23 | Qualifier        | Deportes TolimaDeportes Toli | 1 - 0 | Atlético JuniorAtlético Juni |
| 10 Mar 23 | Qualifier        | EmelecEmelec | 2 - 1 | Deportivo CuencaDeportivo Cue |
| 10 Mar 23 | Qualifier        | UniversitarioUniversitario | 2 - 0 | CiencianoCienciano |
| |
| 04 Apr 23 | r01        | Audax ItalianoAudax Italian | 0 - 1 | Newells Old BoysNewells Old B |
| 04 Apr 23 | r01        | GoiasGoias | 0 - 0 | Independiente Santa FeIndependiente |
| 05 Apr 23 | r01        | Estudiantes de Mérida F.CEstudiantes d | 0 - 1 | San LorenzoSan Lorenzo |
| 05 Apr 23 | r01        | Universidad César VallejoUniversidad C | 1 - 2 | LDU QuitoLDU Quito |
| 05 Apr 23 | r01        | BloomingBlooming | 0 - 1 | Santos FCSantos FC |
| 05 Apr 23 | r01        | Millonarios F.C.Millonarios F | 3 - 0 | Defensa y JusticiaDefensa y Jus |
| 05 Apr 23 | r01        | Oriente PetroleroOriente Petro | 0 - 1 | Estudiantes de la PlataEstudiantes d |
| 05 Apr 23 | r01        | FortalezaFortaleza | 4 - 0 | PalestinoPalestino |
| 05 Apr 23 | r01        | DanubioDanubio | 2 - 0 | EmelecEmelec |
| 06 Apr 23 | r01        | America MGAmerica MG | 4 - 1 | PeñarolPeñarol |
| 06 Apr 23 | r01        | Gimnasia LPGimnasia LP | 0 - 1 | UniversitarioUniversitario |
| 06 Apr 23 | r01        | HuracanHuracan | 4 - 1 | Club GuaraníClub Guaraní |
| 07 Apr 23 | r01        | TacuaryTacuary | 1 - 4 | BragantinoBragantino |
| 07 Apr 23 | r01        | TigreTigre | 0 - 2 | Sao PauloSao Paulo |
| 07 Apr 23 | r01        | MagallanesMagallanes | 2 - 2 | Botafogo RJBotafogo RJ |
| 07 Apr 23 | r01        | Puerto Cabello F.C.Puerto Cabell | 0 - 2 | Deportes TolimaDeportes Toli |
| |
| 18 Apr 23 | r02        | BragantinoBragantino | 5 - 0 | Oriente PetroleroOriente Petro |
| 18 Apr 23 | r02        | Newells Old BoysNewells Old B | 3 - 0 | BloomingBlooming |
| 19 Apr 23 | r02        | Estudiantes de la PlataEstudiantes d | 4 - 0 | TacuaryTacuary |
| 19 Apr 23 | r02        | PalestinoPalestino | 1 - 0 | Estudiantes de Mérida F.CEstudiantes d |
| 19 Apr 23 | r02        | Sao PauloSao Paulo | 2 - 0 | Puerto Cabello F.C.Puerto Cabell |
| 19 Apr 23 | r02        | Independiente Santa FeIndependiente | 2 - 1 | Gimnasia LPGimnasia LP |
| 19 Apr 23 | r02        | Club GuaraníClub Guaraní | 2 - 1 | DanubioDanubio |
| 20 Apr 23 | r02        | Defensa y JusticiaDefensa y Jus | 2 - 1 | America MGAmerica MG |
| 20 Apr 23 | r02        | LDU QuitoLDU Quito | 4 - 0 | MagallanesMagallanes |
| 20 Apr 23 | r02        | San LorenzoSan Lorenzo | 0 - 2 | FortalezaFortaleza |
| 20 Apr 23 | r02        | Santos FCSantos FC | 0 - 0 | Audax ItalianoAudax Italian |
| 20 Apr 23 | r02        | PeñarolPeñarol | 0 - 2 | Millonarios F.C.Millonarios F |
| 21 Apr 23 | r02        | Botafogo RJBotafogo RJ | 4 - 0 | Universidad César VallejoUniversidad C |
| 21 Apr 23 | r02        | UniversitarioUniversitario | 2 - 2 | GoiasGoias |
| 21 Apr 23 | r02        | EmelecEmelec | 1 - 0 | HuracanHuracan |
| 21 Apr 23 | r02        | Deportes TolimaDeportes Toli | 1 - 2 | TigreTigre |
| |
| 02 May 23 | r03        | Deportes TolimaDeportes Toli | 0 - 0 | Sao PauloSao Paulo |
| 02 May 23 | r03        | TacuaryTacuary | 3 - 1 | Oriente PetroleroOriente Petro |
| 02 May 23 | r03        | HuracanHuracan | 1 - 1 | DanubioDanubio |
| 03 May 23 | r03        | MagallanesMagallanes | 2 - 2 | Universidad César VallejoUniversidad C |
| 03 May 23 | r03        | BragantinoBragantino | 0 - 0 | Estudiantes de la PlataEstudiantes d |
| 03 May 23 | r03        | Newells Old BoysNewells Old B | 1 - 0 | Santos FCSantos FC |
| 03 May 23 | r03        | PalestinoPalestino | 0 - 0 | San LorenzoSan Lorenzo |
| 04 May 23 | r03        | Club GuaraníClub Guaraní | 1 - 1 | EmelecEmelec |
| 04 May 23 | r03        | Puerto Cabello F.C.Puerto Cabell | 0 - 3 | TigreTigre |
| 04 May 23 | r03        | Millonarios F.C.Millonarios F | 1 - 1 | America MGAmerica MG |
| 04 May 23 | r03        | Gimnasia LPGimnasia LP | 0 - 2 | GoiasGoias |
| 05 May 23 | r03        | FortalezaFortaleza | 6 - 1 | Estudiantes de Mérida F.CEstudiantes d |
| 05 May 23 | r03        | Botafogo RJBotafogo RJ | 0 - 0 | LDU QuitoLDU Quito |
| 05 May 23 | r03        | Defensa y JusticiaDefensa y Jus | 4 - 1 | PeñarolPeñarol |
| 05 May 23 | r03        | Audax ItalianoAudax Italian | 2 - 0 | BloomingBlooming |
| 05 May 23 | r03        | UniversitarioUniversitario | 2 - 0 | Independiente Santa FeIndependiente |
| |
| 23 May 23 | r04        | Gimnasia LPGimnasia LP | 1 - 0 | Independiente Santa FeIndependiente |
| 23 May 23 | r04        | GoiasGoias | 1 - 0 | UniversitarioUniversitario |
| 24 May 23 | r04        | America MGAmerica MG | 2 - 3 | Defensa y JusticiaDefensa y Jus |
| 24 May 23 | r04        | MagallanesMagallanes | 1 - 1 | LDU QuitoLDU Quito |
| 24 May 23 | r04        | Puerto Cabello F.C.Puerto Cabell | 0 - 2 | Sao PauloSao Paulo |
| 24 May 23 | r04        | Millonarios F.C.Millonarios F | 3 - 1 | PeñarolPeñarol |
| 24 May 23 | r04        | FortalezaFortaleza | 3 - 2 | San LorenzoSan Lorenzo |
| 25 May 23 | r04        | TigreTigre | 0 - 0 | Deportes TolimaDeportes Toli |
| 25 May 23 | r04        | Audax ItalianoAudax Italian | 2 - 1 | Santos FCSantos FC |
| 25 May 23 | r04        | BloomingBlooming | 2 - 3 | Newells Old BoysNewells Old B |
| 25 May 23 | r04        | DanubioDanubio | 0 - 2 | Club GuaraníClub Guaraní |
| 25 May 23 | r04        | TacuaryTacuary | 0 - 4 | Estudiantes de la PlataEstudiantes d |
| 26 May 23 | r04        | HuracanHuracan | 2 - 2 | EmelecEmelec |
| 26 May 23 | r04        | Estudiantes de Mérida F.CEstudiantes d | 1 - 5 | PalestinoPalestino |
| 26 May 23 | r04        | Oriente PetroleroOriente Petro | 0 - 4 | BragantinoBragantino |
| 26 May 23 | r04        | Universidad César VallejoUniversidad C | 2 - 3 | Botafogo RJBotafogo RJ |
| |
| 06 Jun 23 | r05        | Estudiantes de Mérida F.CEstudiantes d | 1 - 0 | FortalezaFortaleza |
| 06 Jun 23 | r05        | PeñarolPeñarol | 0 - 3 | Defensa y JusticiaDefensa y Jus |
| 07 Jun 23 | r05        | America MGAmerica MG | 2 - 0 | Millonarios F.C.Millonarios F |
| 07 Jun 23 | r05        | TigreTigre | 2 - 1 | Puerto Cabello F.C.Puerto Cabell |
| 07 Jun 23 | r05        | Santos FCSantos FC | 1 - 2 | Newells Old BoysNewells Old B |
| 07 Jun 23 | r05        | LDU QuitoLDU Quito | 0 - 0 | Botafogo RJBotafogo RJ |
| 08 Jun 23 | r05        | BloomingBlooming | 1 - 2 | Audax ItalianoAudax Italian |
| 08 Jun 23 | r05        | Estudiantes de la PlataEstudiantes d | 1 - 1 | BragantinoBragantino |
| 08 Jun 23 | r05        | EmelecEmelec | 1 - 1 | Club GuaraníClub Guaraní |
| 08 Jun 23 | r05        | Oriente PetroleroOriente Petro | 1 - 3 | TacuaryTacuary |
| 08 Jun 23 | r05        | GoiasGoias | 0 - 0 | Gimnasia LPGimnasia LP |
| 08 Jun 23 | r05        | DanubioDanubio | 1 - 0 | HuracanHuracan |
| 08 Jun 23 | r05        | Sao PauloSao Paulo | 5 - 0 | Deportes TolimaDeportes Toli |
| 09 Jun 23 | r05        | San LorenzoSan Lorenzo | 0 - 0 | PalestinoPalestino |
| 09 Jun 23 | r05        | Independiente Santa FeIndependiente | 2 - 0 | UniversitarioUniversitario |
| 09 Jun 23 | r05        | Universidad César VallejoUniversidad C | 3 - 2 | MagallanesMagallanes |
| |
| 27 Jun 23 | r06        | San LorenzoSan Lorenzo | 4 - 1 | Estudiantes de Mérida F.CEstudiantes d |
| 27 Jun 23 | r06        | PalestinoPalestino | 1 - 2 | FortalezaFortaleza |
| 28 Jun 23 | r06        | Sao PauloSao Paulo | 2 - 0 | TigreTigre |
| 28 Jun 23 | r06        | Deportes TolimaDeportes Toli | 3 - 1 | Puerto Cabello F.C.Puerto Cabell |