| 18 Apr 23 | r02        | BragantinoBragantino | 5 - 0 | Oriente PetroleroOriente Petro |
| 18 Apr 23 | r02        | Newells Old BoysNewells Old B | 3 - 0 | BloomingBlooming |
| 19 Apr 23 | r02        | Estudiantes de la PlataEstudiantes d | 4 - 0 | TacuaryTacuary |
| 19 Apr 23 | r02        | PalestinoPalestino | 1 - 0 | Estudiantes de Mérida F.CEstudiantes d |
| 19 Apr 23 | r02        | Sao PauloSao Paulo | 2 - 0 | Puerto Cabello F.C.Puerto Cabell |
| 19 Apr 23 | r02        | Independiente Santa FeIndependiente | 2 - 1 | Gimnasia LPGimnasia LP |
| 19 Apr 23 | r02        | Club GuaraníClub Guaraní | 2 - 1 | DanubioDanubio |
| 20 Apr 23 | r02        | Defensa y JusticiaDefensa y Jus | 2 - 1 | America MGAmerica MG |
| 20 Apr 23 | r02        | LDU QuitoLDU Quito | 4 - 0 | MagallanesMagallanes |
| 20 Apr 23 | r02        | San LorenzoSan Lorenzo | 0 - 2 | FortalezaFortaleza |
| 20 Apr 23 | r02        | Santos FCSantos FC | 0 - 0 | Audax ItalianoAudax Italian |
| 20 Apr 23 | r02        | PeñarolPeñarol | 0 - 2 | Millonarios F.C.Millonarios F |
| 21 Apr 23 | r02        | Botafogo RJBotafogo RJ | 4 - 0 | Universidad César VallejoUniversidad C |
| 21 Apr 23 | r02        | UniversitarioUniversitario | 2 - 2 | GoiasGoias |
| 21 Apr 23 | r02        | EmelecEmelec | 1 - 0 | HuracanHuracan |
| 21 Apr 23 | r02        | Deportes TolimaDeportes Toli | 1 - 2 | TigreTigre |