| 31 Jul 21 | r01        | BournemouthBournemouth | 5 - 0 | Milton Keynes DonsMilton Keynes |
| 01 Aug 21 | r01        | Sheffield WedsSheffield Wed | 0 - 0 | Huddersfield TownHuddersfield |
| 10 Aug 21 | r01        | CardiffCardiff | 3 - 2 | Sutton UnitedSutton United |
| 10 Aug 21 | r01        | HartlepoolHartlepool | 0 - 1 | CreweCrewe |
| 10 Aug 21 | r01        | CrawleyCrawley | 2 - 2 | GillinghamGillingham |
| 10 Aug 21 | r01        | Cambridge UnitedCambridge Uni | 0 - 0 | SwindonSwindon |
| 10 Aug 21 | r01        | ExeterExeter | 0 - 0 | WycombeWycombe |
| 10 Aug 21 | r01        | IpswichIpswich | 0 - 1 | NewportNewport |
| 10 Aug 21 | r01        | Forest Green RoversForest Green | 2 - 2 | Bristol CityBristol City |
| 10 Aug 21 | r01        | BlackburnBlackburn | 1 - 2 | MorecambeMorecambe |
| 10 Aug 21 | r01        | Bristol RoversBristol Rover | 0 - 2 | CheltenhamCheltenham |
| 10 Aug 21 | r01        | PeterboroPeterboro | 0 - 4 | PlymouthPlymouth |
| 10 Aug 21 | r01        | StevenageStevenage | 2 - 2 | LutonLuton |
| 10 Aug 21 | r01        | MillwallMillwall | 2 - 1 | PortsmouthPortsmouth |
| 10 Aug 21 | r01        | BirminghamBirmingham | 1 - 0 | ColchesterColchester |
| 10 Aug 21 | r01        | CharltonCharlton | 0 - 1 | AFC WimbledonAFC Wimbledon |
| 10 Aug 21 | r01        | StokeStoke | 2 - 1 | Fleetwood TownFleetwood Tow |
| 10 Aug 21 | r01        | DerbyDerby | 3 - 3 | Salford CitySalford City |
| 10 Aug 21 | r01        | ShrewsburyShrewsbury | 2 - 2 | LincolnLincoln |
| 10 Aug 21 | r01        | MansfieldMansfield | 0 - 3 | PrestonPreston |
| 10 Aug 21 | r01        | Port ValePort Vale | 1 - 2 | SunderlandSunderland |
| 10 Aug 21 | r01        | Sheffield UnitedSheffield Uni | 1 - 0 | CarlisleCarlisle |
| 10 Aug 21 | r01        | Harrogate Town FCHarrogate Tow | - | RochdaleRochdale |
| 10 Aug 21 | r01        | WalsallWalsall | 0 - 0 | DoncasterDoncaster |
| 10 Aug 21 | r01        | OldhamOldham | 2 - 2 | TranmereTranmere |
| 10 Aug 21 | r01        | RotherhamRotherham | 1 - 2 | AccringtonAccrington |
| 10 Aug 21 | r01        | BarrowBarrow | 1 - 0 | ScunthorpeScunthorpe |
| 10 Aug 21 | r01        | HullHull | 1 - 1 | WiganWigan |
| 10 Aug 21 | r01        | ReadingReading | 0 - 3 | SwanseaSwansea |
| 10 Aug 21 | r01        | BoltonBolton | 0 - 0 | BarnsleyBarnsley |
| 11 Aug 21 | r01        | BurtonBurton | 1 - 1 | Oxford UtdOxford Utd |
| 11 Aug 21 | r01        | CoventryCoventry | 1 - 2 | NorthamptonNorthampton |
| 11 Aug 21 | r01        | Leyton OrientLeyton Orient | 1 - 1 | QPRQPR |
| 11 Aug 21 | r01        | BlackpoolBlackpool | 3 - 0 | MiddlesbroughMiddlesbrough |
| 11 Aug 21 | r01        | Nottingham F.Nottingham F. | 2 - 1 | BradfordBradford |
| |
| 24 Aug 21 | r02        | QPRQPR | 2 - 0 | Oxford UtdOxford Utd |
| 24 Aug 21 | r02        | SwanseaSwansea | 4 - 1 | PlymouthPlymouth |
| 24 Aug 21 | r02        | NorwichNorwich | 6 - 0 | BournemouthBournemouth |
| 24 Aug 21 | r02        | OldhamOldham | 0 - 0 | AccringtonAccrington |
| 24 Aug 21 | r02        | WatfordWatford | 1 - 0 | Crystal PalaceCrystal Palac |
| 24 Aug 21 | r02        | NorthamptonNorthampton | 0 - 1 | AFC WimbledonAFC Wimbledon |
| 24 Aug 21 | r02        | StevenageStevenage | 2 - 2 | WycombeWycombe |
| 24 Aug 21 | r02        | GillinghamGillingham | 1 - 1 | CheltenhamCheltenham |
| 24 Aug 21 | r02        | BirminghamBirmingham | 0 - 2 | FulhamFulham |
| 24 Aug 21 | r02        | CardiffCardiff | 0 - 2 | BrightonBrighton |
| 24 Aug 21 | r02        | MillwallMillwall | 3 - 1 | Cambridge UnitedCambridge Uni |
| 24 Aug 21 | r02        | BrentfordBrentford | 3 - 1 | Forest Green RoversForest Green |
| 24 Aug 21 | r02        | BarrowBarrow | 0 - 6 | Aston VillaAston Villa |
| 24 Aug 21 | r02        | LeedsLeeds | 3 - 0 | CreweCrewe |
| 24 Aug 21 | r02        | BlackpoolBlackpool | 2 - 3 | SunderlandSunderland |
| 24 Aug 21 | r02        | MorecambeMorecambe | 2 - 4 | PrestonPreston |
| 24 Aug 21 | r02        | ShrewsburyShrewsbury | 0 - 2 | RochdaleRochdale |
| 24 Aug 21 | r02        | StokeStoke | 2 - 0 | DoncasterDoncaster |
| 24 Aug 21 | r02        | Sheffield UnitedSheffield Uni | 2 - 1 | DerbyDerby |
| 24 Aug 21 | r02        | Huddersfield TownHuddersfield | 1 - 2 | EvertonEverton |
| 24 Aug 21 | r02        | WiganWigan | 0 - 0 | BoltonBolton |
| 24 Aug 21 | r02        | Nottingham F.Nottingham F. | 0 - 4 | WolvesWolves |
| 25 Aug 21 | r02        | NewportNewport | 0 - 8 | SouthamptonSouthampton |
| 25 Aug 21 | r02        | NewcastleNewcastle | 0 - 0 | BurnleyBurnley |
| 25 Aug 21 | r02        | West BromWest Brom | 0 - 6 | ArsenalArsenal |
| |
| 21 Sep 21 | r03        | QPRQPR | 2 - 2 | EvertonEverton |
| 21 Sep 21 | r03        | Manchester CityManchester Ci | 6 - 1 | WycombeWycombe |
| 21 Sep 21 | r03        | Sheffield UnitedSheffield Uni | 2 - 2 | SouthamptonSouthampton |
| 21 Sep 21 | r03        | BurnleyBurnley | 4 - 1 | RochdaleRochdale |
| 21 Sep 21 | r03        | NorwichNorwich | 0 - 3 | LiverpoolLiverpool |
| 21 Sep 21 | r03        | WiganWigan | 0 - 2 | SunderlandSunderland |
| 21 Sep 21 | r03        | WatfordWatford | 1 - 3 | StokeStoke |
| 21 Sep 21 | r03        | BrentfordBrentford | 7 - 0 | OldhamOldham |
| 21 Sep 21 | r03        | FulhamFulham | 0 - 0 | LeedsLeeds |
| 21 Sep 21 | r03        | PrestonPreston | 4 - 1 | CheltenhamCheltenham |
| 22 Sep 21 | r03        | BrightonBrighton | 2 - 0 | SwanseaSwansea |
| 22 Sep 21 | r03        | WolvesWolves | 2 - 2 | TottenhamTottenham |
| 22 Sep 21 | r03        | MillwallMillwall | 0 - 2 | LeicesterLeicester |
| 22 Sep 21 | r03        | ArsenalArsenal | 3 - 0 | AFC WimbledonAFC Wimbledon |
| 22 Sep 21 | r03        | ChelseaChelsea | 1 - 1 | Aston VillaAston Villa |
| 22 Sep 21 | r03        | Manchester UnitedManchester Un | 0 - 1 | West HamWest Ham |
| |
| 26 Oct 21 | r16        | QPRQPR | 0 - 0 | SunderlandSunderland |
| 26 Oct 21 | r16        | ChelseaChelsea | 1 - 1 | SouthamptonSouthampton |
| 26 Oct 21 | r16        | ArsenalArsenal | 2 - 0 | LeedsLeeds |
| 27 Oct 21 | r16        | StokeStoke | 1 - 2 | BrentfordBrentford |
| 27 Oct 21 | r16        | West HamWest Ham | 0 - 0 | Manchester CityManchester Ci |
| 27 Oct 21 | r16        | LeicesterLeicester | 2 - 2 | BrightonBrighton |
| 27 Oct 21 | r16        | BurnleyBurnley | 0 - 1 | TottenhamTottenham |
| 27 Oct 21 | r16        | PrestonPreston | 0 - 2 | LiverpoolLiverpool |
| |
| 21 Dec 21 | QF        | ArsenalArsenal | 5 - 1 | SunderlandSunderland |
| 22 Dec 21 | QF        | TottenhamTottenham | 2 - 1 | West HamWest Ham |
| 22 Dec 21 | QF        | BrentfordBrentford | 0 - 2 | ChelseaChelsea |
| 22 Dec 21 | QF        | LiverpoolLiverpool | 3 - 3 | LeicesterLeicester |
| |
| 05 Jan 22 | SF        | ChelseaChelsea | 2 - 0 | TottenhamTottenham |
| 12 Jan 22 | SF        | TottenhamTottenham | 0 - 1 | ChelseaChelsea |
| 13 Jan 22 | SF        | LiverpoolLiverpool | 0 - 0 | ArsenalArsenal |
| 20 Jan 22 | SF        | ArsenalArsenal | 0 - 2 | LiverpoolLiverpool |
| |
| 27 Feb 22 | Final        | ChelseaChelsea | 0 - 0 | LiverpoolLiverpool |