| 12 Mar 10 | r01        | Brisbane BroncosBrisbane Bron | 30 - 24 | North Queensland Cowboys North Queensl |
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| 20 Mar 10 | r02        | North Queensland Cowboys North Queensl | 28 - 20 | Penrith PanthersPenrith Panth |
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| 26 Mar 10 | r03        | St. George Illawara DragoSt. George Il | 33 - 8 | North Queensland Cowboys North Queensl |
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| 03 Apr 10 | r04        | North Queensland Cowboys North Queensl | 32 - 18 | Gold Coast TitansGold Coast Ti |
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| 10 Apr 10 | r05        | North Queensland Cowboys North Queensl | 16 - 23 | Wests TigersWests Tigers |
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| 17 Apr 10 | r06        | Newcastle Knights Newcastle Kni | 36 - 18 | North Queensland Cowboys North Queensl |
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| 23 Apr 10 | r07        | North Queensland Cowboys North Queensl | 18 - 24 | Parramatta EelsParramatta Ee |
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| 01 May 10 | r08        | North Queensland Cowboys North Queensl | 6 - 34 | Melbourne StormMelbourne Sto |
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| 10 May 10 | r09        | Sydney RoostersSydney Rooste | 14 - 32 | North Queensland Cowboys North Queensl |
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| 15 May 10 | r10        | New Zealand WarriorsNew Zealand W | 24 - 12 | North Queensland Cowboys North Queensl |
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| 29 May 10 | r12        | North Queensland Cowboys North Queensl | 20 - 24 | Manly Sea EaglesManly Sea Eag |
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| 07 Jun 10 | r13        | South Sydney RabbitohsSouth Sydney | 32 - 4 | North Queensland Cowboys North Queensl |
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| 12 Jun 10 | r14        | North Queensland Cowboys North Queensl | 16 - 8 | Canberra RaidersCanberra Raid |
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| 19 Jun 10 | r15        | Melbourne StormMelbourne Sto | 58 - 12 | North Queensland Cowboys North Queensl |
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| 26 Jun 10 | r16        | North Queensland Cowboys North Queensl | 19 - 20 | Cronulla SharksCronulla Shar |
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| 12 Jul 10 | r18        | Parramatta EelsParramatta Ee | 36 - 24 | North Queensland Cowboys North Queensl |
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| 19 Jul 10 | r19        | Wests TigersWests Tigers | 26 - 16 | North Queensland Cowboys North Queensl |
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| 24 Jul 10 | r20        | North Queensland Cowboys North Queensl | 28 - 24 | Newcastle Knights Newcastle Kni |
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| 30 Jul 10 | r21        | Penrith PanthersPenrith Panth | 24 - 16 | North Queensland Cowboys North Queensl |
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| 06 Aug 10 | r22        | North Queensland Cowboys North Queensl | 26 - 34 | Brisbane BroncosBrisbane Bron |
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| 14 Aug 10 | r23        | Gold Coast TitansGold Coast Ti | 37 - 18 | North Queensland Cowboys North Queensl |
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| 21 Aug 10 | r24        | North Queensland Cowboys North Queensl | 20 - 22 | Canterbury Bankstown BullCanterbury Ba |
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| 28 Aug 10 | r25        | Canberra RaidersCanberra Raid | 48 - 4 | North Queensland Cowboys North Queensl |
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| 04 Sep 10 | r26        | North Queensland Cowboys North Queensl | 8 - 18 | Sydney RoostersSydney Rooste |