| 06 Sep 88 | r01        | New York GiantsNew York Gian | 27 - 20 | Washington CommandersWashington Co |
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| 11 Sep 88 | r02        | New York GiantsNew York Gian | 17 - 20 | San Francisco 49ersSan Francisco |
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| 18 Sep 88 | r03        | Dallas CowboysDallas Cowboy | 10 - 12 | New York GiantsNew York Gian |
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| 25 Sep 88 | r04        | New York GiantsNew York Gian | 31 - 45 | Los Angeles RamsLos Angeles R |
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| 02 Oct 88 | r05        | Washington CommandersWashington Co | 23 - 24 | New York GiantsNew York Gian |
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| 11 Oct 88 | r06        | Philadelphia EaglesPhiladelphia | 24 - 13 | New York GiantsNew York Gian |
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| 16 Oct 88 | r07        | New York GiantsNew York Gian | 30 - 10 | Detroit LionsDetroit Lions |
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| 23 Oct 88 | r08        | Atlanta FalconsAtlanta Falco | 16 - 23 | New York GiantsNew York Gian |
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| 30 Oct 88 | r09        | Detroit LionsDetroit Lions | 10 - 13 | New York GiantsNew York Gian |
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| 06 Nov 88 | r10        | New York GiantsNew York Gian | 29 - 21 | Dallas CowboysDallas Cowboy |
| 13 Nov 88 | r10        | Arizona CardinalsArizona Cardi | 24 - 17 | New York GiantsNew York Gian |
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| 20 Nov 88 | r12        | New York GiantsNew York Gian | 17 - 23 | Philadelphia EaglesPhiladelphia |
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| 28 Nov 88 | r13        | New Orleans SaintsNew Orleans S | 12 - 13 | New York GiantsNew York Gian |
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| 04 Dec 88 | r14        | New York GiantsNew York Gian | 44 - 7 | Arizona CardinalsArizona Cardi |
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| 11 Dec 88 | r15        | New York GiantsNew York Gian | 28 - 12 | Kansas City ChiefsKansas City C |
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| 18 Dec 88 | r16        | New York JetsNew York Jets | 27 - 21 | New York GiantsNew York Gian |