| 04 Sep 88 | r01        | Kansas City ChiefsKansas City C | 3 - 6 | Cleveland BrownsCleveland Bro |
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| 11 Sep 88 | r02        | Cleveland BrownsCleveland Bro | 3 - 23 | New York JetsNew York Jets |
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| 20 Sep 88 | r03        | Cleveland BrownsCleveland Bro | 23 - 17 | Indianapolis ColtsIndianapolis |
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| 25 Sep 88 | r04        | Cincinnati BengalsCincinnati Be | 24 - 17 | Cleveland BrownsCleveland Bro |
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| 02 Oct 88 | r05        | Pittsburgh SteelersPittsburgh St | 9 - 23 | Cleveland BrownsCleveland Bro |
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| 09 Oct 88 | r06        | Cleveland BrownsCleveland Bro | 10 - 16 | Seattle SeahawksSeattle Seaha |
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| 16 Oct 88 | r07        | Cleveland BrownsCleveland Bro | 19 - 3 | Philadelphia EaglesPhiladelphia |
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| 23 Oct 88 | r08        | Arizona CardinalsArizona Cardi | 21 - 29 | Cleveland BrownsCleveland Bro |
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| 30 Oct 88 | r09        | Cleveland BrownsCleveland Bro | 23 - 16 | Cincinnati BengalsCincinnati Be |
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| 08 Nov 88 | r10        | Tennessee TitansTennessee Tit | 24 - 17 | Cleveland BrownsCleveland Bro |
| 13 Nov 88 | r10        | Denver BroncosDenver Bronco | 30 - 7 | Cleveland BrownsCleveland Bro |
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| 20 Nov 88 | r12        | Cleveland BrownsCleveland Bro | 27 - 7 | Pittsburgh SteelersPittsburgh St |
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| 27 Nov 88 | r13        | Washington CommandersWashington Co | 13 - 17 | Cleveland BrownsCleveland Bro |
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| 04 Dec 88 | r14        | Cleveland BrownsCleveland Bro | 24 - 21 | Dallas CowboysDallas Cowboy |
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| 13 Dec 88 | r15        | Miami DolphinsMiami Dolphin | 38 - 31 | Cleveland BrownsCleveland Bro |
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| 18 Dec 88 | r16        | Cleveland BrownsCleveland Bro | 28 - 23 | Tennessee TitansTennessee Tit |
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| 24 Dec 88 | Playoff        | Cleveland BrownsCleveland Bro | 23 - 24 | Tennessee TitansTennessee Tit |