| 07 Sep 80 | r01        | Seattle SeahawksSeattle Seaha | 13 - 34 | Los Angeles ChargersLos Angeles C |
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| 14 Sep 80 | r02        | Los Angeles ChargersLos Angeles C | 30 - 24 | Las Vegas RaidersLas Vegas Rai |
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| 21 Sep 80 | r03        | Denver BroncosDenver Bronco | 13 - 30 | Los Angeles ChargersLos Angeles C |
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| 28 Sep 80 | r04        | Kansas City ChiefsKansas City C | 7 - 24 | Los Angeles ChargersLos Angeles C |
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| 05 Oct 80 | r05        | Los Angeles ChargersLos Angeles C | 24 - 26 | Buffalo BillsBuffalo Bills |
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| 12 Oct 80 | r06        | Las Vegas RaidersLas Vegas Rai | 38 - 24 | Los Angeles ChargersLos Angeles C |
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| 19 Oct 80 | r07        | Los Angeles ChargersLos Angeles C | 44 - 7 | New York GiantsNew York Gian |
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| 27 Oct 80 | r08        | Dallas CowboysDallas Cowboy | 42 - 31 | Los Angeles ChargersLos Angeles C |
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| 02 Nov 80 | r09        | Cincinnati BengalsCincinnati Be | 14 - 31 | Los Angeles ChargersLos Angeles C |
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| 09 Nov 80 | r10        | Los Angeles ChargersLos Angeles C | 13 - 20 | Denver BroncosDenver Bronco |
| 16 Nov 80 | r10        | Los Angeles ChargersLos Angeles C | 20 - 7 | Kansas City ChiefsKansas City C |
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| 21 Nov 80 | r12        | Miami DolphinsMiami Dolphin | 24 - 27 | Los Angeles ChargersLos Angeles C |
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| 30 Nov 80 | r13        | Los Angeles ChargersLos Angeles C | 22 - 21 | Philadelphia EaglesPhiladelphia |
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| 07 Dec 80 | r14        | Washington CommandersWashington Co | 40 - 17 | Los Angeles ChargersLos Angeles C |
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| 13 Dec 80 | r15        | Los Angeles ChargersLos Angeles C | 21 - 14 | Seattle SeahawksSeattle Seaha |
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| 23 Dec 80 | r16        | Los Angeles ChargersLos Angeles C | 26 - 17 | Pittsburgh SteelersPittsburgh St |
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| 03 Jan 81 | QF        | Los Angeles ChargersLos Angeles C | 20 - 14 | Buffalo BillsBuffalo Bills |
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| 11 Jan 81 | SF        | Los Angeles ChargersLos Angeles C | 27 - 34 | Las Vegas RaidersLas Vegas Rai |