| 07 Sep 80 | r01        | Arizona CardinalsArizona Cardi | 35 - 41 | New York GiantsNew York Gian |
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| 14 Sep 80 | r02        | New York GiantsNew York Gian | 21 - 23 | Washington CommandersWashington Co |
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| 23 Sep 80 | r03        | Philadelphia EaglesPhiladelphia | 35 - 3 | New York GiantsNew York Gian |
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| 28 Sep 80 | r04        | New York GiantsNew York Gian | 7 - 28 | Los Angeles RamsLos Angeles R |
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| 05 Oct 80 | r05        | Dallas CowboysDallas Cowboy | 24 - 3 | New York GiantsNew York Gian |
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| 12 Oct 80 | r06        | New York GiantsNew York Gian | 16 - 31 | Philadelphia EaglesPhiladelphia |
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| 19 Oct 80 | r07        | Los Angeles ChargersLos Angeles C | 44 - 7 | New York GiantsNew York Gian |
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| 26 Oct 80 | r08        | New York GiantsNew York Gian | 9 - 14 | Denver BroncosDenver Bronco |
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| 02 Nov 80 | r09        | Tampa Bay BuccaneersTampa Bay Buc | 30 - 13 | New York GiantsNew York Gian |
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| 09 Nov 80 | r10        | New York GiantsNew York Gian | 38 - 35 | Dallas CowboysDallas Cowboy |
| 16 Nov 80 | r10        | New York GiantsNew York Gian | 27 - 21 | Green Bay PackersGreen Bay Pac |
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| 23 Nov 80 | r12        | San Francisco 49ersSan Francisco | 12 - 0 | New York GiantsNew York Gian |
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| 30 Nov 80 | r13        | New York GiantsNew York Gian | 7 - 23 | Arizona CardinalsArizona Cardi |
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| 07 Dec 80 | r14        | Seattle SeahawksSeattle Seaha | 21 - 27 | New York GiantsNew York Gian |
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| 13 Dec 80 | r15        | Washington CommandersWashington Co | 16 - 13 | New York GiantsNew York Gian |
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| 21 Dec 80 | r16        | New York GiantsNew York Gian | 17 - 33 | Las Vegas RaidersLas Vegas Rai |