| 07 Sep 80 | r01        | Philadelphia EaglesPhiladelphia | 27 - 6 | Denver BroncosDenver Bronco |
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| 14 Sep 80 | r02        | Denver BroncosDenver Bronco | 41 - 20 | Dallas CowboysDallas Cowboy |
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| 21 Sep 80 | r03        | Denver BroncosDenver Bronco | 13 - 30 | Los Angeles ChargersLos Angeles C |
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| 30 Sep 80 | r04        | New England PatriotsNew England P | 23 - 14 | Denver BroncosDenver Bronco |
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| 05 Oct 80 | r05        | Cleveland BrownsCleveland Bro | 16 - 19 | Denver BroncosDenver Bronco |
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| 14 Oct 80 | r06        | Denver BroncosDenver Bronco | 20 - 17 | Washington CommandersWashington Co |
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| 19 Oct 80 | r07        | Denver BroncosDenver Bronco | 17 - 23 | Kansas City ChiefsKansas City C |
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| 26 Oct 80 | r08        | New York GiantsNew York Gian | 9 - 14 | Denver BroncosDenver Bronco |
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| 02 Nov 80 | r09        | Denver BroncosDenver Bronco | 16 - 20 | Tennessee TitansTennessee Tit |
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| 09 Nov 80 | r10        | Los Angeles ChargersLos Angeles C | 13 - 20 | Denver BroncosDenver Bronco |
| 16 Nov 80 | r10        | Denver BroncosDenver Bronco | 31 - 24 | New York JetsNew York Jets |
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| 23 Nov 80 | r12        | Denver BroncosDenver Bronco | 36 - 20 | Seattle SeahawksSeattle Seaha |
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| 02 Dec 80 | r13        | Las Vegas RaidersLas Vegas Rai | 9 - 3 | Denver BroncosDenver Bronco |
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| 07 Dec 80 | r14        | Kansas City ChiefsKansas City C | 31 - 14 | Denver BroncosDenver Bronco |
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| 14 Dec 80 | r15        | Denver BroncosDenver Bronco | 21 - 24 | Las Vegas RaidersLas Vegas Rai |
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| 21 Dec 80 | r16        | Seattle SeahawksSeattle Seaha | 17 - 25 | Denver BroncosDenver Bronco |