| 07 Sep 80 | r01        | New England PatriotsNew England P | 34 - 17 | Cleveland BrownsCleveland Bro |
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| 16 Sep 80 | r02        | Cleveland BrownsCleveland Bro | 7 - 16 | Tennessee TitansTennessee Tit |
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| 21 Sep 80 | r03        | Cleveland BrownsCleveland Bro | 20 - 13 | Kansas City ChiefsKansas City C |
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| 28 Sep 80 | r04        | Tampa Bay BuccaneersTampa Bay Buc | 27 - 34 | Cleveland BrownsCleveland Bro |
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| 05 Oct 80 | r05        | Cleveland BrownsCleveland Bro | 16 - 19 | Denver BroncosDenver Bronco |
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| 12 Oct 80 | r06        | Seattle SeahawksSeattle Seaha | 3 - 27 | Cleveland BrownsCleveland Bro |
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| 19 Oct 80 | r07        | Cleveland BrownsCleveland Bro | 26 - 21 | Green Bay PackersGreen Bay Pac |
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| 26 Oct 80 | r08        | Cleveland BrownsCleveland Bro | 27 - 26 | Pittsburgh SteelersPittsburgh St |
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| 04 Nov 80 | r09        | Cleveland BrownsCleveland Bro | 27 - 21 | Chicago BearsChicago Bears |
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| 09 Nov 80 | r10        | Indianapolis ColtsIndianapolis | 27 - 28 | Cleveland BrownsCleveland Bro |
| 16 Nov 80 | r10        | Pittsburgh SteelersPittsburgh St | 16 - 13 | Cleveland BrownsCleveland Bro |
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| 23 Nov 80 | r12        | Cleveland BrownsCleveland Bro | 31 - 7 | Cincinnati BengalsCincinnati Be |
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| 30 Nov 80 | r13        | Tennessee TitansTennessee Tit | 14 - 17 | Cleveland BrownsCleveland Bro |
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| 07 Dec 80 | r14        | Cleveland BrownsCleveland Bro | 17 - 14 | New York JetsNew York Jets |
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| 14 Dec 80 | r15        | Minnesota VikingsMinnesota Vik | 28 - 23 | Cleveland BrownsCleveland Bro |
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| 21 Dec 80 | r16        | Cincinnati BengalsCincinnati Be | 24 - 27 | Cleveland BrownsCleveland Bro |
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| 04 Jan 81 | QF        | Cleveland BrownsCleveland Bro | 12 - 14 | Las Vegas RaidersLas Vegas Rai |