| 19 Oct 21 | r02        | Heroes Den BoschHeroes Den Bo | 87 - 82 | BK OpavaBK Opava |
| 19 Oct 21 | r02        | DonarDonar | 64 - 71 | BayreuthBayreuth |
| 20 Oct 21 | r02        | BC Avtodor SaratovBC Avtodor Sa | 91 - 84 | Pallacanestro ReggianaPallacanestro |
| 20 Oct 21 | r02        | Hapoel Gilboa GalilHapoel Gilboa | 90 - 91 | Basket ZaragozaBasket Zarago |
| 20 Oct 21 | r02        | Ionikos Nikaias BCIonikos Nikai | 81 - 92 | Antwerp GiantsAntwerp Giant |
| 20 Oct 21 | r02        | Peristeri BCPeristeri BC | 85 - 83 | Bakken BearsBakken Bears |
| 20 Oct 21 | r02        | Hapoel Eilat BCHapoel Eilat | 78 - 86 | Kyiv-BasketKyiv-Basket |
| 20 Oct 21 | r02        | Legia WarszawaLegia Warszaw | 83 - 66 | Szolnoki Olaj KKSzolnoki Olaj |
| 20 Oct 21 | r02        | KK Mornar BarKK Mornar Bar | 87 - 74 | ZZ LeidenZZ Leiden |
| 20 Oct 21 | r02        | Trefl SopotTrefl Sopot | 90 - 81 | BC Rilski SportistBC Rilski Spo |
| 20 Oct 21 | r02        | Iraklis BCIraklis BC | 63 - 64 | Bahçeşehir Koleji SKBahçeşehir Ko |
| 20 Oct 21 | r02        | London LionsLondon Lions | 68 - 58 | Kapfenberg BullsKapfenberg Bu |
| 20 Oct 21 | r02        | Sporting CP BasketballSporting CP B | 75 - 65 | Belfius Mons-HainautBelfius Mons- |
| 20 Oct 21 | r02        | FC Porto BasketballFC Porto Bask | 75 - 63 | CSM OradeaCSM Oradea |
| 20 Oct 21 | r02        | S.L. BenficaS.L. Benfica | 83 - 69 | Parma BasketParma Basket |
| 15 Dec 21 | r02        | Bahçeşehir Koleji SKBahçeşehir Ko | 90 - 76 | Bakken BearsBakken Bears |
| 15 Dec 21 | r02        | Parma BasketParma Basket | 92 - 78 | BayreuthBayreuth |
| 15 Dec 21 | r02        | Kyiv-BasketKyiv-Basket | 79 - 80 | Pallacanestro ReggianaPallacanestro |
| 15 Dec 21 | r02        | Crailsheim MerlinsCrailsheim Me | 91 - 86 | Antwerp GiantsAntwerp Giant |
| 15 Dec 21 | r02        | Sporting CP BasketballSporting CP B | 77 - 83 | CSM OradeaCSM Oradea |
| 15 Dec 21 | r02        | ZZ LeidenZZ Leiden | 78 - 90 | Legia WarszawaLegia Warszaw |
| 15 Dec 21 | r02        | S.L. BenficaS.L. Benfica | 67 - 79 | Trefl SopotTrefl Sopot |
| 08 Jan 22 | r02        | BC Avtodor SaratovBC Avtodor Sa | 84 - 81 | London LionsLondon Lions |