| 10 Dec 21 | r01        | Newcastle FalconsNewcastle Fal | 31 - 26 | Worcester WarriorsWorcester War |
| 10 Dec 21 | r01        | Lyon OULyon OU | 19 - 13 | GloucesterGloucester |
| 11 Dec 21 | r01        | USA PerpignanUSA Perpignan | 22 - 16 | DragonsDragons |
| 11 Dec 21 | r01        | SaracensSaracens | 18 - 21 | EdinburghEdinburgh |
| 11 Dec 21 | r01        | ZebreZebre | 13 - 26 | Biarritz OlympiqueBiarritz Olym |
| 11 Dec 21 | r01        | Section PaloiseSection Paloi | 17 - 33 | London IrishLondon Irish |
| |
| 17 Dec 21 | r02        | RC ToulonnaisRC Toulonnais | 28 - 14 | ZebreZebre |
| 17 Dec 21 | r02        | DragonsDragons | 28 - 41 | Lyon OULyon OU |
| 17 Dec 21 | r02        | GloucesterGloucester | 54 - 25 | BenettonBenetton |
| 18 Dec 21 | r02        | London IrishLondon Irish | 0 - 0 | CA BriveCA Brive |
| 18 Dec 21 | r02        | Worcester WarriorsWorcester War | 0 - 0 | Biarritz OlympiqueBiarritz Olym |
| 18 Dec 21 | r02        | Section PaloiseSection Paloi | 28 - 0 | SaracensSaracens |
| |
| 14 Jan 22 | r03        | Biarritz OlympiqueBiarritz Olym | 13 - 17 | Newcastle FalconsNewcastle Fal |
| 14 Jan 22 | r03        | CA BriveCA Brive | 33 - 25 | Section PaloiseSection Paloi |
| 15 Jan 22 | r03        | Worcester WarriorsWorcester War | 23 - 34 | RC ToulonnaisRC Toulonnais |
| 15 Jan 22 | r03        | USA PerpignanUSA Perpignan | 6 - 37 | Lyon OULyon OU |
| 15 Jan 22 | r03        | London IrishLondon Irish | 21 - 20 | EdinburghEdinburgh |
| 15 Jan 22 | r03        | BenettonBenetton | 23 - 9 | DragonsDragons |
| |
| 21 Jan 22 | r04        | EdinburghEdinburgh | 66 - 3 | CA BriveCA Brive |
| 21 Jan 22 | r04        | Lyon OULyon OU | 25 - 10 | BenettonBenetton |
| 22 Jan 22 | r04        | RC ToulonnaisRC Toulonnais | 28 - 0 | Newcastle FalconsNewcastle Fal |
| 22 Jan 22 | r04        | GloucesterGloucester | 68 - 19 | USA PerpignanUSA Perpignan |
| 22 Jan 22 | r04        | ZebreZebre | 26 - 36 | Worcester WarriorsWorcester War |
| 23 Jan 22 | r04        | SaracensSaracens | 45 - 24 | London IrishLondon Irish |
| |
| 08 Apr 22 | r05        | CA BriveCA Brive | 5 - 55 | SaracensSaracens |
| 08 Apr 22 | r05        | EdinburghEdinburgh | 54 - 5 | Section PaloiseSection Paloi |
| 09 Apr 22 | r05        | Biarritz OlympiqueBiarritz Olym | 20 - 17 | RC ToulonnaisRC Toulonnais |
| 09 Apr 22 | r05        | DragonsDragons | 21 - 26 | GloucesterGloucester |
| 09 Apr 22 | r05        | BenettonBenetton | 17 - 7 | USA PerpignanUSA Perpignan |
| 09 Apr 22 | r05        | Newcastle FalconsNewcastle Fal | 25 - 22 | ZebreZebre |
| |
| 15 Apr 22 | r06        | Biarritz OlympiqueBiarritz Olym | 29 - 39 | WaspsWasps |
| 15 Apr 22 | r06        | Newcastle FalconsNewcastle Fal | 17 - 27 | GlasgowGlasgow |
| 15 Apr 22 | r06        | London IrishLondon Irish | 64 - 27 | Castres OlympiqueCastres Olymp |
| 15 Apr 22 | r06        | Lyon OULyon OU | 31 - 17 | Worcester WarriorsWorcester War |
| 16 Apr 22 | r06        | GloucesterGloucester | 31 - 21 | Northampton SaintsNorthampton S |
| 16 Apr 22 | r06        | EdinburghEdinburgh | 41 - 19 | Bath RugbyBath Rugby |
| 16 Apr 22 | r06        | RC ToulonnaisRC Toulonnais | 36 - 17 | BenettonBenetton |
| 17 Apr 22 | r06        | SaracensSaracens | 40 - 33 | Cardiff RugbyCardiff Rugby |
| |
| 06 May 22 | QF        | GloucesterGloucester | 15 - 44 | SaracensSaracens |
| 07 May 22 | QF        | EdinburghEdinburgh | 30 - 34 | WaspsWasps |
| 07 May 22 | QF        | Lyon OULyon OU | 35 - 27 | GlasgowGlasgow |
| 08 May 22 | QF        | RC ToulonnaisRC Toulonnais | 19 - 18 | London IrishLondon Irish |
| |
| 14 May 22 | SF        | Lyon OULyon OU | 20 - 18 | WaspsWasps |
| 14 May 22 | SF        | RC ToulonnaisRC Toulonnais | 25 - 16 | SaracensSaracens |
| |
| 27 May 22 | Final        | Lyon OULyon OU | 30 - 12 | RC ToulonnaisRC Toulonnais |