| 13 Aug 22 | r01        | 1874 Northwich1874 Northwic | 0 - 0 | Prescot CablesPrescot Cable |
| 13 Aug 22 | r01        | BootleBootle | 0 - 4 | Leek TownLeek Town |
| 13 Aug 22 | r01        | ColneColne | 0 - 2 | Kidsgrove AthleticKidsgrove Ath |
| 13 Aug 22 | r01        | Glossop North EndGlossop North | 1 - 0 | City of LiverpoolCity of Liver |
| 13 Aug 22 | r01        | MacclesfieldMacclesfield | 3 - 0 | ClitheroeClitheroe |
| 13 Aug 22 | r01        | Newcastle TownNewcastle Tow | 1 - 1 | WittonWitton |
| 13 Aug 22 | r01        | Ramsbottom UnitedRamsbottom Un | 1 - 3 | Hanley TownHanley Town |
| 13 Aug 22 | r01        | Runcorn LinnetsRuncorn Linne | 3 - 1 | WidnesWidnes |
| 13 Aug 22 | r01        | Skelmersdale UnitedSkelmersdale | 2 - 3 | TraffordTrafford |
| 13 Aug 22 | r01        | WorkingtonWorkington | 0 - 1 | MossleyMossley |
| |
| 16 Aug 22 | r02        | City of LiverpoolCity of Liver | 1 - 2 | Skelmersdale UnitedSkelmersdale |
| 16 Aug 22 | r02        | ClitheroeClitheroe | 2 - 0 | Ramsbottom UnitedRamsbottom Un |
| 16 Aug 22 | r02        | Hanley TownHanley Town | 1 - 2 | Newcastle TownNewcastle Tow |
| 16 Aug 22 | r02        | Kidsgrove AthleticKidsgrove Ath | 3 - 3 | 1874 Northwich1874 Northwic |
| 16 Aug 22 | r02        | Leek TownLeek Town | 1 - 3 | MacclesfieldMacclesfield |
| 16 Aug 22 | r02        | MossleyMossley | 1 - 0 | Runcorn LinnetsRuncorn Linne |
| 16 Aug 22 | r02        | Prescot CablesPrescot Cable | 1 - 1 | WorkingtonWorkington |
| 16 Aug 22 | r02        | TraffordTrafford | 1 - 1 | ColneColne |
| 16 Aug 22 | r02        | WidnesWidnes | 1 - 1 | BootleBootle |
| 16 Aug 22 | r02        | WittonWitton | 0 - 1 | Glossop North EndGlossop North |
| |
| 23 Aug 22 | r03        | ColneColne | 2 - 3 | MossleyMossley |
| 23 Aug 22 | r03        | Glossop North EndGlossop North | 1 - 1 | Leek TownLeek Town |
| 23 Aug 22 | r03        | Runcorn LinnetsRuncorn Linne | 0 - 0 | Hanley TownHanley Town |
| 23 Aug 22 | r03        | Skelmersdale UnitedSkelmersdale | 0 - 1 | ClitheroeClitheroe |
| 23 Aug 22 | r03        | WorkingtonWorkington | 2 - 1 | TraffordTrafford |
| |
| 27 Aug 22 | r04        | City of LiverpoolCity of Liver | 0 - 1 | MacclesfieldMacclesfield |
| 27 Aug 22 | r04        | ClitheroeClitheroe | 1 - 3 | 1874 Northwich1874 Northwic |
| 27 Aug 22 | r04        | Hanley TownHanley Town | 2 - 4 | Skelmersdale UnitedSkelmersdale |
| 27 Aug 22 | r04        | Kidsgrove AthleticKidsgrove Ath | 1 - 0 | Glossop North EndGlossop North |
| 27 Aug 22 | r04        | Leek TownLeek Town | 1 - 1 | Ramsbottom UnitedRamsbottom Un |
| 27 Aug 22 | r04        | MossleyMossley | 1 - 1 | Newcastle TownNewcastle Tow |
| 27 Aug 22 | r04        | Prescot CablesPrescot Cable | 1 - 0 | Runcorn LinnetsRuncorn Linne |
| 27 Aug 22 | r04        | TraffordTrafford | 2 - 3 | BootleBootle |
| 27 Aug 22 | r04        | WidnesWidnes | 1 - 1 | ColneColne |
| 27 Aug 22 | r04        | WittonWitton | 3 - 2 | WorkingtonWorkington |
| |
| 29 Aug 22 | r05        | 1874 Northwich1874 Northwic | 0 - 0 | Leek TownLeek Town |
| 29 Aug 22 | r05        | BootleBootle | 2 - 1 | City of LiverpoolCity of Liver |
| 29 Aug 22 | r05        | ColneColne | 1 - 2 | Hanley TownHanley Town |
| 29 Aug 22 | r05        | Glossop North EndGlossop North | 0 - 0 | TraffordTrafford |
| 29 Aug 22 | r05        | MacclesfieldMacclesfield | 5 - 0 | WidnesWidnes |
| 29 Aug 22 | r05        | Newcastle TownNewcastle Tow | 1 - 1 | Kidsgrove AthleticKidsgrove Ath |
| 29 Aug 22 | r05        | Ramsbottom UnitedRamsbottom Un | 3 - 1 | MossleyMossley |
| 29 Aug 22 | r05        | Runcorn LinnetsRuncorn Linne | 1 - 0 | WittonWitton |
| 29 Aug 22 | r05        | Skelmersdale UnitedSkelmersdale | 3 - 2 | Prescot CablesPrescot Cable |
| 29 Aug 22 | r05        | WorkingtonWorkington | 0 - 1 | ClitheroeClitheroe |
| |
| 03 Sep 22 | r07        | 1874 Northwich1874 Northwic | 1 - 1 | Ramsbottom UnitedRamsbottom Un |
| 03 Sep 22 | r07        | MossleyMossley | 0 - 2 | Leek TownLeek Town |
| |
| 06 Sep 22 | r06        | ColneColne | 2 - 1 | City of LiverpoolCity of Liver |
| 06 Sep 22 | r06        | Leek TownLeek Town | 1 - 1 | Kidsgrove AthleticKidsgrove Ath |
| 06 Sep 22 | r06        | Newcastle TownNewcastle Tow | 2 - 2 | 1874 Northwich1874 Northwic |
| 06 Sep 22 | r06        | Ramsbottom UnitedRamsbottom Un | 0 - 3 | WorkingtonWorkington |
| 06 Sep 22 | r06        | Skelmersdale UnitedSkelmersdale | 1 - 4 | Runcorn LinnetsRuncorn Linne |
| 06 Sep 22 | r06        | TraffordTrafford | 2 - 0 | MossleyMossley |
| 06 Sep 22 | r06        | WidnesWidnes | 0 - 3 | Prescot CablesPrescot Cable |
| 06 Sep 22 | r06        | WittonWitton | 1 - 0 | MacclesfieldMacclesfield |
| |
| 17 Sep 22 | r08        | BootleBootle | 0 - 1 | WorkingtonWorkington |
| 17 Sep 22 | r08        | ColneColne | 1 - 0 | 1874 Northwich1874 Northwic |
| 17 Sep 22 | r08        | Skelmersdale UnitedSkelmersdale | 0 - 2 | Glossop North EndGlossop North |
| 17 Sep 22 | r08        | TraffordTrafford | 1 - 1 | Kidsgrove AthleticKidsgrove Ath |
| 17 Sep 22 | r08        | WittonWitton | 0 - 2 | MossleyMossley |
| |
| 20 Sep 22 | r03        | 1874 Northwich1874 Northwic | 2 - 0 | City of LiverpoolCity of Liver |
| 20 Sep 22 | r03        | BootleBootle | 2 - 1 | WittonWitton |
| |
| 20 Sep 22 | r08        | Leek TownLeek Town | 4 - 1 | Prescot CablesPrescot Cable |
| 20 Sep 22 | r08        | Ramsbottom UnitedRamsbottom Un | 0 - 5 | MacclesfieldMacclesfield |
| |
| 24 Sep 22 | r07        | WorkingtonWorkington | 2 - 1 | Skelmersdale UnitedSkelmersdale |
| |
| 24 Sep 22 | r08        | Hanley TownHanley Town | 2 - 3 | City of LiverpoolCity of Liver |
| |
| 27 Sep 22 | r03        | MacclesfieldMacclesfield | 5 - 0 | Kidsgrove AthleticKidsgrove Ath |
| 27 Sep 22 | r03        | Newcastle TownNewcastle Tow | 2 - 1 | WidnesWidnes |
| |
| 27 Sep 22 | r07        | Prescot CablesPrescot Cable | 2 - 1 | WittonWitton |
| 27 Sep 22 | r07        | Runcorn LinnetsRuncorn Linne | 1 - 1 | BootleBootle |
| |
| 27 Sep 22 | r28        | Glossop North EndGlossop North | 2 - 4 | Hanley TownHanley Town |
| |
| 01 Oct 22 | r09        | 1874 Northwich1874 Northwic | 2 - 1 | Skelmersdale UnitedSkelmersdale |
| 01 Oct 22 | r09        | City of LiverpoolCity of Liver | 3 - 2 | TraffordTrafford |
| 01 Oct 22 | r09        | Glossop North EndGlossop North | 2 - 1 | Ramsbottom UnitedRamsbottom Un |
| 01 Oct 22 | r09        | Kidsgrove AthleticKidsgrove Ath | 1 - 1 | WittonWitton |
| 01 Oct 22 | r09        | MacclesfieldMacclesfield | 1 - 2 | BootleBootle |
| 01 Oct 22 | r09        | MossleyMossley | 4 - 1 | WidnesWidnes |
| 01 Oct 22 | r09        | Prescot CablesPrescot Cable | 0 - 0 | Newcastle TownNewcastle Tow |
| 01 Oct 22 | r09        | Runcorn LinnetsRuncorn Linne | 2 - 0 | ColneColne |
| 01 Oct 22 | r09        | WorkingtonWorkington | 1 - 1 | Leek TownLeek Town |
| |
| 04 Oct 22 | r03        | Ramsbottom UnitedRamsbottom Un | 2 - 1 | Prescot CablesPrescot Cable |
| |
| 08 Oct 22 | r10        | BootleBootle | 1 - 2 | Ramsbottom UnitedRamsbottom Un |
| 08 Oct 22 | r10        | Hanley TownHanley Town | 0 - 2 | WidnesWidnes |
| 08 Oct 22 | r10        | Kidsgrove AthleticKidsgrove Ath | 2 - 2 | MossleyMossley |
| 08 Oct 22 | r10        | Prescot CablesPrescot Cable | 2 - 0 | Glossop North EndGlossop North |
| 08 Oct 22 | r10        | Skelmersdale UnitedSkelmersdale | 1 - 3 | Newcastle TownNewcastle Tow |
| |
| 08 Oct 22 | r27        | TraffordTrafford | 3 - 2 | City of LiverpoolCity of Liver |
| |
| 11 Oct 22 | r06        | BootleBootle | 0 - 4 | ClitheroeClitheroe |
| |
| 11 Oct 22 | r08        | Newcastle TownNewcastle Tow | 0 - 2 | Runcorn LinnetsRuncorn Linne |
| |
| 15 Oct 22 | r11        | 1874 Northwich1874 Northwic | 2 - 0 | TraffordTrafford |
| 15 Oct 22 | r11        | City of LiverpoolCity of Liver | 2 - 1 | Kidsgrove AthleticKidsgrove Ath |
| 15 Oct 22 | r11        | ColneColne | 0 - 2 | Prescot CablesPrescot Cable |
| 15 Oct 22 | r11        | Glossop North EndGlossop North | 1 - 2 | MacclesfieldMacclesfield |
| 15 Oct 22 | r11        | Leek TownLeek Town | 4 - 1 | Hanley TownHanley Town |
| 15 Oct 22 | r11        | MossleyMossley | 1 - 1 | ClitheroeClitheroe |
| 15 Oct 22 | r11        | Newcastle TownNewcastle Tow | 1 - 0 | BootleBootle |
| 15 Oct 22 | r11        | Ramsbottom UnitedRamsbottom Un | 3 - 5 | Skelmersdale UnitedSkelmersdale |
| 15 Oct 22 | r11        | WidnesWidnes | 2 - 3 | WittonWitton |
| 15 Oct 22 | r11        | WorkingtonWorkington | 2 - 1 | Runcorn LinnetsRuncorn Linne |
| |
| 18 Oct 22 | r07        | City of LiverpoolCity of Liver | 4 - 0 | WidnesWidnes |