| 28 Aug 21 | SF        | HC Kriens-LuzernHC Kriens-Luz | 24 - 31 | S.L. BenficaS.L. Benfica |
| 04 Sep 21 | SF        | S.L. BenficaS.L. Benfica | 29 - 18 | HC Kriens-LuzernHC Kriens-Luz |
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| 21 Sep 21 | Final        | Rhein-Neckar LöwenRhein-Neckar | 31 - 31 | S.L. BenficaS.L. Benfica |
| 28 Sep 21 | Final        | S.L. BenficaS.L. Benfica | 33 - 28 | Rhein-Neckar LöwenRhein-Neckar |
| |
| 19 Oct 21 | r01        | TBV LemgoTBV Lemgo | 29 - 30 | S.L. BenficaS.L. Benfica |
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| 26 Oct 21 | r02        | S.L. BenficaS.L. Benfica | 38 - 35 | Chekhovskiye MedvediChekhovskiye |
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| 16 Nov 21 | r03        | Riihimäki CocksRiihimäki Coc | 32 - 37 | S.L. BenficaS.L. Benfica |
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| 23 Nov 21 | r04        | S.L. BenficaS.L. Benfica | 25 - 33 | GOG HåndboldGOG Håndbold |
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| 30 Nov 21 | r05        | S.L. BenficaS.L. Benfica | 37 - 23 | Riihimäki CocksRiihimäki Coc |
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| 07 Dec 21 | r06        | HBC NantesHBC Nantes | 33 - 33 | S.L. BenficaS.L. Benfica |
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| 15 Feb 22 | r07        | S.L. BenficaS.L. Benfica | 35 - 30 | TBV LemgoTBV Lemgo |
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| 22 Feb 22 | r08        | Chekhovskiye MedvediChekhovskiye | 27 - 32 | S.L. BenficaS.L. Benfica |
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| 01 Mar 22 | r09        | GOG HåndboldGOG Håndbold | 39 - 38 | S.L. BenficaS.L. Benfica |
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| 08 Mar 22 | r10        | S.L. BenficaS.L. Benfica | 31 - 30 | HBC NantesHBC Nantes |
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| 29 Mar 22 | Playoff        | Fenix Toulouse HandballFenix Toulous | 38 - 34 | S.L. BenficaS.L. Benfica |
| 05 Apr 22 | Playoff        | S.L. BenficaS.L. Benfica | 36 - 30 | Fenix Toulouse HandballFenix Toulous |
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| 26 Apr 22 | QF        | S.L. BenficaS.L. Benfica | 36 - 29 | RK Gorenje VelenjeRK Gorenje Ve |
| 03 May 22 | QF        | RK Gorenje VelenjeRK Gorenje Ve | 27 - 27 | S.L. BenficaS.L. Benfica |
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| 28 May 22 | SF        | Wisła PłockWisła Płock | 19 - 26 | S.L. BenficaS.L. Benfica |
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| 29 May 22 | Final        | S.L. BenficaS.L. Benfica | 40 - 39 | SC MagdeburgSC Magdeburg |