| 27 Aug 21 | SF        | RK Trimo TrebnjeRK Trimo Treb | 31 - 25 | TTH HolstebroTTH Holstebro |
| 28 Aug 21 | SF        | Maccabi Rishon LeZion HanMaccabi Risho | 26 - 29 | HBC CSKA MoscowHBC CSKA Mosc |
| 28 Aug 21 | SF        | Bjerringbro-Silkeborg HånBjerringbro-S | 22 - 23 | Ystads IFYstads IF |
| 28 Aug 21 | SF        | Csurgói KKCsurgói KK | 23 - 27 | HC Dobrogea Sud ConstanțaHC Dobrogea S |
| 28 Aug 21 | SF        | KS Azoty-PuławyKS Azoty-Puła | 29 - 21 | MRK SesveteMRK Sesvete |
| 28 Aug 21 | SF        | Celje Pivovarna LaškoCelje Pivovar | 33 - 29 | GOG HåndboldGOG Håndbold |
| 28 Aug 21 | SF        | HC Kriens-LuzernHC Kriens-Luz | 24 - 31 | S.L. BenficaS.L. Benfica |
| 28 Aug 21 | SF        | Rhein-Neckar LöwenRhein-Neckar | 38 - 22 | Spor Toto SKSpor Toto SK |
| 28 Aug 21 | SF        | Associação Atlética de ÁgAssociação At | 26 - 26 | CB Ciudad de LogroñoCB Ciudad de |
| 28 Aug 21 | SF        | Alpla HC HardAlpla HC Hard | 23 - 27 | Fenix Toulouse HandballFenix Toulous |
| 29 Aug 21 | SF        | HBC CSKA MoscowHBC CSKA Mosc | 29 - 23 | Maccabi Rishon LeZion HanMaccabi Risho |
| 29 Aug 21 | SF        | Spor Toto SKSpor Toto SK | 22 - 42 | Rhein-Neckar LöwenRhein-Neckar |
| 29 Aug 21 | SF        | Balatonfüredi KSEBalatonfüredi | 27 - 25 | HK MalmöHK Malmö |
| 29 Aug 21 | SF        | NMC Górnik ZabrzeNMC Górnik Za | 19 - 29 | ØIF ArendalØIF Arendal |
| 29 Aug 21 | SF        | RK VojvodinaRK Vojvodina | 26 - 20 | Kadetten SchaffhausenKadetten Scha |
| 31 Aug 21 | SF        | SPR TarnówSPR Tarnów | 23 - 28 | RK Nexe NašiceRK Nexe Našic |
| 01 Sep 21 | SF        | RK Nexe NašiceRK Nexe Našic | 32 - 28 | SPR TarnówSPR Tarnów |
| 03 Sep 21 | SF        | RK PorečRK Poreč | 18 - 22 | Valur HandballValur Handbal |
| 03 Sep 21 | SF        | RK Tineks ProletRK Tineks Pro | 21 - 36 | BM GranollersBM Granollers |
| 04 Sep 21 | SF        | Ystads IFYstads IF | 25 - 27 | Bjerringbro-Silkeborg HånBjerringbro-S |
| 04 Sep 21 | SF        | GOG HåndboldGOG Håndbold | 36 - 25 | Celje Pivovarna LaškoCelje Pivovar |
| 04 Sep 21 | SF        | S.L. BenficaS.L. Benfica | 29 - 18 | HC Kriens-LuzernHC Kriens-Luz |
| 04 Sep 21 | SF        | BM GranollersBM Granollers | 27 - 29 | RK Tineks ProletRK Tineks Pro |
| 04 Sep 21 | SF        | Fenix Toulouse HandballFenix Toulous | 39 - 32 | Alpla HC HardAlpla HC Hard |
| 04 Sep 21 | SF        | Valur HandballValur Handbal | 22 - 21 | RK PorečRK Poreč |
| 04 Sep 21 | SF        | CB Ciudad de LogroñoCB Ciudad de | 34 - 28 | Associação Atlética de ÁgAssociação At |
| 04 Sep 21 | SF        | MRK SesveteMRK Sesvete | 25 - 37 | KS Azoty-PuławyKS Azoty-Puła |
| 04 Sep 21 | SF        | Kadetten SchaffhausenKadetten Scha | 34 - 23 | RK VojvodinaRK Vojvodina |
| 05 Sep 21 | SF        | HK MalmöHK Malmö | 22 - 20 | Balatonfüredi KSEBalatonfüredi |
| 05 Sep 21 | SF        | ØIF ArendalØIF Arendal | 28 - 29 | NMC Górnik ZabrzeNMC Górnik Za |
| 05 Sep 21 | SF        | HC Dobrogea Sud ConstanțaHC Dobrogea S | 31 - 28 | Csurgói KKCsurgói KK |
| 05 Sep 21 | SF        | TTH HolstebroTTH Holstebro | 35 - 28 | RK Trimo TrebnjeRK Trimo Treb |
| |
| 21 Sep 21 | Final        | ØIF ArendalØIF Arendal | 27 - 27 | PAUC HandballPAUC Handball |
| 21 Sep 21 | Final        | KS Azoty-PuławyKS Azoty-Puła | 24 - 32 | Füchse BerlinFüchse Berlin |
| 21 Sep 21 | Final        | Bjerringbro-Silkeborg HånBjerringbro-S | 33 - 27 | RK Nexe NašiceRK Nexe Našic |
| 21 Sep 21 | Final        | GOG HåndboldGOG Håndbold | 30 - 24 | Mors-Thy HåndboldMors-Thy Hånd |
| 21 Sep 21 | Final        | Kadetten SchaffhausenKadetten Scha | 36 - 33 | BM GranollersBM Granollers |
| 21 Sep 21 | Final        | USAM Nîmes GardUSAM Nîmes Ga | 36 - 29 | HBC CSKA MoscowHBC CSKA Mosc |
| 21 Sep 21 | Final        | Rhein-Neckar LöwenRhein-Neckar | 31 - 31 | S.L. BenficaS.L. Benfica |
| 21 Sep 21 | Final        | Wisła PłockWisła Płock | 25 - 14 | HC Dobrogea Sud ConstanțaHC Dobrogea S |
| 21 Sep 21 | Final        | CB Ciudad de LogroñoCB Ciudad de | 34 - 30 | CB Ademar LeónCB Ademar Leó |
| 21 Sep 21 | Final        | Sporting CP HandballSporting CP H | 31 - 25 | TTH HolstebroTTH Holstebro |
| 21 Sep 21 | Final        | Fenix Toulouse HandballFenix Toulous | 30 - 24 | HK MalmöHK Malmö |
| 21 Sep 21 | Final        | Valur HandballValur Handbal | 26 - 27 | TBV LemgoTBV Lemgo |
| 28 Sep 21 | Final        | PAUC HandballPAUC Handball | 40 - 22 | ØIF ArendalØIF Arendal |
| 28 Sep 21 | Final        | HBC CSKA MoscowHBC CSKA Mosc | 29 - 29 | USAM Nîmes GardUSAM Nîmes Ga |
| 28 Sep 21 | Final        | HC Dobrogea Sud ConstanțaHC Dobrogea S | 26 - 20 | Wisła PłockWisła Płock |
| 28 Sep 21 | Final        | Füchse BerlinFüchse Berlin | 33 - 29 | KS Azoty-PuławyKS Azoty-Puła |
| 28 Sep 21 | Final        | TTH HolstebroTTH Holstebro | 28 - 31 | Sporting CP HandballSporting CP H |
| 28 Sep 21 | Final        | HK MalmöHK Malmö | 25 - 29 | Fenix Toulouse HandballFenix Toulous |
| 28 Sep 21 | Final        | Mors-Thy HåndboldMors-Thy Hånd | 27 - 27 | GOG HåndboldGOG Håndbold |
| 28 Sep 21 | Final        | RK Nexe NašiceRK Nexe Našic | 32 - 26 | Bjerringbro-Silkeborg HånBjerringbro-S |
| 28 Sep 21 | Final        | CB Ademar LeónCB Ademar Leó | 28 - 27 | CB Ciudad de LogroñoCB Ciudad de |
| 28 Sep 21 | Final        | S.L. BenficaS.L. Benfica | 33 - 28 | Rhein-Neckar LöwenRhein-Neckar |
| 28 Sep 21 | Final        | BM GranollersBM Granollers | 27 - 32 | Kadetten SchaffhausenKadetten Scha |
| 28 Sep 21 | Final        | TBV LemgoTBV Lemgo | 27 - 21 | Valur HandballValur Handbal |
| |
| 19 Oct 21 | r01        | AEK H.C.AEK H.C. | 34 - 26 | Tatabánya KCTatabánya KC |
| 19 Oct 21 | r01        | Chekhovskiye MedvediChekhovskiye | 32 - 39 | GOG HåndboldGOG Håndbold |
| 19 Oct 21 | r01        | Riihimäki CocksRiihimäki Coc | 28 - 40 | HBC NantesHBC Nantes |
| 19 Oct 21 | r01        | Füchse BerlinFüchse Berlin | 32 - 30 | Fenix Toulouse HandballFenix Toulous |
| 19 Oct 21 | r01        | RK Gorenje VelenjeRK Gorenje Ve | 27 - 31 | SC MagdeburgSC Magdeburg |
| 19 Oct 21 | r01        | IK SävehofIK Sävehof | 43 - 31 | CB Ciudad de LogroñoCB Ciudad de |
| 19 Oct 21 | r01        | PAUC HandballPAUC Handball | 29 - 30 | RK Nexe NašiceRK Nexe Našic |
| 19 Oct 21 | r01        | RK Eurofarm PelisterRK Eurofarm P | 21 - 26 | USAM Nîmes GardUSAM Nîmes Ga |
| 19 Oct 21 | r01        | TBV LemgoTBV Lemgo | 29 - 30 | S.L. BenficaS.L. Benfica |
| 19 Oct 21 | r01        | Pfadi WinterthurPfadi Wintert | 23 - 35 | Wisła PłockWisła Płock |
| 19 Oct 21 | r01        | HT Tatran PrešovHT Tatran Pre | 27 - 25 | CD BidasoaCD Bidasoa |
| 19 Oct 21 | r01        | Sporting CP HandballSporting CP H | 29 - 28 | Kadetten SchaffhausenKadetten Scha |
| |
| 26 Oct 21 | r02        | GOG HåndboldGOG Håndbold | 46 - 30 | Riihimäki CocksRiihimäki Coc |
| 26 Oct 21 | r02        | Kadetten SchaffhausenKadetten Scha | 28 - 28 | RK Eurofarm PelisterRK Eurofarm P |
| 26 Oct 21 | r02        | RK Nexe NašiceRK Nexe Našic | 39 - 31 | IK SävehofIK Sävehof |
| 26 Oct 21 | r02        | USAM Nîmes GardUSAM Nîmes Ga | 26 - 27 | AEK H.C.AEK H.C. |
| 26 Oct 21 | r02        | SC MagdeburgSC Magdeburg | 31 - 27 | PAUC HandballPAUC Handball |
| 26 Oct 21 | r02        | Tatabánya KCTatabánya KC | 23 - 37 | Sporting CP HandballSporting CP H |
| 26 Oct 21 | r02        | Wisła PłockWisła Płock | 33 - 29 | Fenix Toulouse HandballFenix Toulous |
| 26 Oct 21 | r02        | S.L. BenficaS.L. Benfica | 38 - 35 | Chekhovskiye MedvediChekhovskiye |
| 26 Oct 21 | r02        | CD BidasoaCD Bidasoa | 32 - 28 | Pfadi WinterthurPfadi Wintert |
| 26 Oct 21 | r02        | Füchse BerlinFüchse Berlin | 36 - 23 | HT Tatran PrešovHT Tatran Pre |
| 26 Oct 21 | r02        | CB Ciudad de LogroñoCB Ciudad de | 31 - 26 | RK Gorenje VelenjeRK Gorenje Ve |
| 26 Oct 21 | r02        | HBC NantesHBC Nantes | 27 - 28 | TBV LemgoTBV Lemgo |
| |
| 16 Nov 21 | r03        | AEK H.C.AEK H.C. | 27 - 30 | RK Eurofarm PelisterRK Eurofarm P |
| 16 Nov 21 | r03        | PAUC HandballPAUC Handball | 25 - 30 | IK SävehofIK Sävehof |
| 16 Nov 21 | r03        | Chekhovskiye MedvediChekhovskiye | 28 - 30 | TBV LemgoTBV Lemgo |
| 16 Nov 21 | r03        | Riihimäki CocksRiihimäki Coc | 32 - 37 | S.L. BenficaS.L. Benfica |
| 16 Nov 21 | r03        | RK Gorenje VelenjeRK Gorenje Ve | 34 - 28 | RK Nexe NašiceRK Nexe Našic |
| 16 Nov 21 | r03        | HT Tatran PrešovHT Tatran Pre | 29 - 33 | Pfadi WinterthurPfadi Wintert |
| 16 Nov 21 | r03        | Tatabánya KCTatabánya KC | 31 - 23 | Kadetten SchaffhausenKadetten Scha |
| 16 Nov 21 | r03        | CD BidasoaCD Bidasoa | 24 - 26 | Fenix Toulouse HandballFenix Toulous |
| 16 Nov 21 | r03        | CB Ciudad de LogroñoCB Ciudad de | 29 - 29 | SC MagdeburgSC Magdeburg |
| 16 Nov 21 | r03        | HBC NantesHBC Nantes | 27 - 24 | GOG HåndboldGOG Håndbold |
| 16 Nov 21 | r03        | USAM Nîmes GardUSAM Nîmes Ga | 33 - 27 | Sporting CP HandballSporting CP H |
| 16 Nov 21 | r03        | Wisła PłockWisła Płock | 24 - 28 | Füchse BerlinFüchse Berlin |
| |
| 23 Nov 21 | r04        | S.L. BenficaS.L. Benfica | 25 - 33 | GOG HåndboldGOG Håndbold |
| 23 Nov 21 | r04        | Chekhovskiye MedvediChekhovskiye | 31 - 35 | HBC NantesHBC Nantes |
| 23 Nov 21 | r04        | RK Eurofarm PelisterRK Eurofarm P | 33 - 20 | Tatabánya KCTatabánya KC |
| 23 Nov 21 | r04        | PAUC HandballPAUC Handball | 26 - 26 | RK Gorenje VelenjeRK Gorenje Ve |
| 23 Nov 21 | r04        | Kadetten SchaffhausenKadetten Scha | 25 - 25 | USAM Nîmes GardUSAM Nîmes Ga |
| 23 Nov 21 | r04        | TBV LemgoTBV Lemgo | 39 - 30 | Riihimäki CocksRiihimäki Coc |
| 23 Nov 21 | r04        | RK Nexe NašiceRK Nexe Našic | 31 - 30 | CB Ciudad de LogroñoCB Ciudad de |
| 23 Nov 21 | r04        | HT Tatran PrešovHT Tatran Pre | 23 - 27 | Füchse BerlinFüchse Berlin |