| 17 Oct 21 | r01  | SC VillaSC Villa | - | BUL Jinja FCBUL Jinja FC |
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| 23 Oct 21 | r02 | Arua HillArua Hill | - | SC VillaSC Villa |
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| 27 Oct 21 | r03 | VipersVipers | - | SC VillaSC Villa |
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| 29 Oct 21 | r04 | SC VillaSC Villa | 1 - 0 | Uganda Police FCUganda Police |
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| 02 Nov 21 | r05 | SC VillaSC Villa | - | Wakiso GiantsWakiso Giants |
| 03 Nov 21 | r05 | SC VillaSC Villa | 1 - 3 | Wakiso GiantsWakiso Giants |
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| 20 Nov 21 | r06 | ExpressExpress | 0 - 0 | SC VillaSC Villa |
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| 23 Nov 21 | r01 | SC VillaSC Villa | 1 - 2 | BUL Jinja FCBUL Jinja FC |
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| 26 Nov 21 | r07 | SC VillaSC Villa | 2 - 1 | OnduparakaOnduparaka |
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| 30 Nov 21 | r08 | Mbarara CityMbarara City | 1 - 0 | SC VillaSC Villa |
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| 07 Dec 21 | r09 | SC VillaSC Villa | 2 - 2 | URAURA |
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| 10 Dec 21 | r10 | GaddafiGaddafi | 2 - 1 | SC VillaSC Villa |
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| 14 Dec 21 | r02 | Arua HillArua Hill | 2 - 2 | SC VillaSC Villa |
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| 18 Dec 21 | r11 | SC VillaSC Villa | 1 - 1 | Kampala Capital City AuthKampala Capit |
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| 22 Dec 21 | r12 | Busoga UnitedBusoga United | 0 - 1 | SC VillaSC Villa |
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| 27 Dec 21 | r13 | SC VillaSC Villa | 4 - 0 | Tooro UnitedTooro United |
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| 04 Jan 22 | r14 | Bright StarsBright Stars | 1 - 0 | SC VillaSC Villa |
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| 08 Jan 22 | r15 | SC VillaSC Villa | 0 - 0 | UPDFUPDF |
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| 02 Feb 22 | r03 | VipersVipers | 3 - 0 | SC VillaSC Villa |
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| 06 Feb 22 | r16 | UPDFUPDF | 0 - 0 | SC VillaSC Villa |
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| 11 Feb 22 | r17 | SC VillaSC Villa | 1 - 2 | Bright StarsBright Stars |
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| 16 Feb 22 | r18 | Tooro UnitedTooro United | 1 - 1 | SC VillaSC Villa |
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| 03 Mar 22 | r19 | SC VillaSC Villa | 0 - 1 | Busoga UnitedBusoga United |
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| 12 Mar 22 | r20 | Kampala Capital City AuthKampala Capit | 0 - 0 | SC VillaSC Villa |
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| 16 Mar 22 | r30 | SC VillaSC Villa | 1 - 0 | GaddafiGaddafi |
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| 27 Mar 22 | r21 | URAURA | 3 - 1 | SC VillaSC Villa |
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| 30 Mar 22 | r26 | Wakiso GiantsWakiso Giants | 1 - 2 | SC VillaSC Villa |
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| 09 Apr 22 | r23 | SC VillaSC Villa | 1 - 2 | ExpressExpress |
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| 15 Apr 22 | r28 | OnduparakaOnduparaka | 1 - 0 | SC VillaSC Villa |
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| 19 Apr 22 | r27 | SC VillaSC Villa | 2 - 1 | Mbarara CityMbarara City |
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| 02 May 22 | r25 | Uganda Police FCUganda Police | 0 - 0 | SC VillaSC Villa |
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| 07 May 22 | r24 | SC VillaSC Villa | 0 - 0 | VipersVipers |
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| 13 May 22 | r29 | SC VillaSC Villa | 2 - 1 | Arua HillArua Hill |
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| 21 May 22 | r22 | BUL Jinja FCBUL Jinja FC | 1 - 0 | SC VillaSC Villa |
Team 2021-2022 Schedules
Buhimba Saints
BUL Jinja
Calvary
Express
Gaddafi
Kampala Capital City Authority
Kitara
Lugazi
Maroons
Mbarara City
NEC FC
SC Villa
Uganda Police
UPDF
URA
Vipers
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Poster
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