| 15 Oct 21 | r01        | ExpressExpress | 0 - 2 | Arua HillArua Hill |
| 15 Oct 21 | r01        | Mbarara CityMbarara City | 3 - 1 | Bright StarsBright Stars |
| 15 Oct 21 | r01        | OnduparakaOnduparaka | 1 - 1 | UPDFUPDF |
| 17 Oct 21 | r01        | Uganda Police FCUganda Police | 0 - 2 | VipersVipers |
| 17 Oct 21 | r01        | Wakiso GiantsWakiso Giants | 0 - 3 | Kampala Capital City AuthKampala Capit |
| 17 Oct 21 | r01        | SC VillaSC Villa | - | BUL Jinja FCBUL Jinja FC |
| 18 Oct 21 | r01        | GaddafiGaddafi | 0 - 2 | Busoga UnitedBusoga United |
| |
| 22 Oct 21 | r02        | VipersVipers | 5 - 0 | Wakiso GiantsWakiso Giants |
| 22 Oct 21 | r02        | BUL Jinja FCBUL Jinja FC | 2 - 1 | Uganda Police FCUganda Police |
| 22 Oct 21 | r02        | Bright StarsBright Stars | 0 - 1 | OnduparakaOnduparaka |
| 23 Oct 21 | r02        | Arua HillArua Hill | - | SC VillaSC Villa |
| 23 Oct 21 | r02        | Kampala Capital City AuthKampala Capit | 2 - 1 | GaddafiGaddafi |
| 23 Oct 21 | r02        | Tooro UnitedTooro United | 1 - 0 | Mbarara CityMbarara City |
| 23 Oct 21 | r02        | UPDFUPDF | 1 - 0 | ExpressExpress |
| |
| 26 Oct 21 | r03        | Arua HillArua Hill | 0 - 0 | OnduparakaOnduparaka |
| 26 Oct 21 | r03        | BUL Jinja FCBUL Jinja FC | 0 - 1 | ExpressExpress |
| 26 Oct 21 | r03        | Uganda Police FCUganda Police | 0 - 1 | Wakiso GiantsWakiso Giants |
| 26 Oct 21 | r03        | Tooro UnitedTooro United | 1 - 1 | GaddafiGaddafi |
| 26 Oct 21 | r03        | Bright StarsBright Stars | - | URAURA |
| 27 Oct 21 | r03        | Busoga UnitedBusoga United | 0 - 1 | Kampala Capital City AuthKampala Capit |
| 27 Oct 21 | r03        | VipersVipers | - | SC VillaSC Villa |
| |
| 29 Oct 21 | r04        | URAURA | 3 - 1 | UPDFUPDF |
| 29 Oct 21 | r04        | GaddafiGaddafi | 1 - 0 | Bright StarsBright Stars |
| 29 Oct 21 | r04        | Mbarara CityMbarara City | 2 - 1 | Arua HillArua Hill |
| 29 Oct 21 | r04        | SC VillaSC Villa | 1 - 0 | Uganda Police FCUganda Police |
| 30 Oct 21 | r04        | ExpressExpress | 2 - 2 | VipersVipers |
| 30 Oct 21 | r04        | OnduparakaOnduparaka | 0 - 2 | BUL Jinja FCBUL Jinja FC |
| 30 Oct 21 | r04        | Kampala Capital City AuthKampala Capit | 2 - 0 | Tooro UnitedTooro United |
| 30 Oct 21 | r04        | Wakiso GiantsWakiso Giants | 1 - 0 | Busoga UnitedBusoga United |
| |
| 02 Nov 21 | r05        | Arua HillArua Hill | 3 - 2 | URAURA |
| 02 Nov 21 | r05        | BUL Jinja FCBUL Jinja FC | 1 - 0 | Mbarara CityMbarara City |
| 02 Nov 21 | r05        | Uganda Police FCUganda Police | 1 - 2 | ExpressExpress |
| 02 Nov 21 | r05        | SC VillaSC Villa | - | Wakiso GiantsWakiso Giants |
| 02 Nov 21 | r05        | Bright StarsBright Stars | 1 - 1 | Kampala Capital City AuthKampala Capit |
| 02 Nov 21 | r05        | UPDFUPDF | 2 - 2 | GaddafiGaddafi |
| 02 Nov 21 | r05        | VipersVipers | 1 - 0 | OnduparakaOnduparaka |
| 03 Nov 21 | r05        | SC VillaSC Villa | 1 - 3 | Wakiso GiantsWakiso Giants |
| 05 Nov 21 | r05        | Tooro UnitedTooro United | 1 - 3 | Busoga UnitedBusoga United |
| |
| 06 Nov 21 | r03        | UPDFUPDF | 1 - 0 | Mbarara CityMbarara City |
| |
| 19 Nov 21 | r06        | Mbarara CityMbarara City | 1 - 2 | VipersVipers |
| 19 Nov 21 | r06        | GaddafiGaddafi | 1 - 0 | Arua HillArua Hill |
| 19 Nov 21 | r06        | Kampala Capital City AuthKampala Capit | 2 - 1 | UPDFUPDF |
| 19 Nov 21 | r06        | Wakiso GiantsWakiso Giants | 3 - 0 | Tooro UnitedTooro United |
| 19 Nov 21 | r06        | Busoga UnitedBusoga United | 0 - 0 | Bright StarsBright Stars |
| 20 Nov 21 | r06        | ExpressExpress | 0 - 0 | SC VillaSC Villa |
| 20 Nov 21 | r06        | OnduparakaOnduparaka | 1 - 0 | Uganda Police FCUganda Police |
| 20 Nov 21 | r06        | URAURA | 2 - 2 | BUL Jinja FCBUL Jinja FC |
| |
| 23 Nov 21 | r01        | URAURA | 6 - 1 | Tooro UnitedTooro United |
| 23 Nov 21 | r01        | SC VillaSC Villa | 1 - 2 | BUL Jinja FCBUL Jinja FC |
| |
| 26 Nov 21 | r07        | Arua HillArua Hill | 0 - 1 | Kampala Capital City AuthKampala Capit |
| 26 Nov 21 | r07        | SC VillaSC Villa | 2 - 1 | OnduparakaOnduparaka |
| 26 Nov 21 | r07        | ExpressExpress | 1 - 0 | Wakiso GiantsWakiso Giants |
| 26 Nov 21 | r07        | Uganda Police FCUganda Police | 0 - 0 | Mbarara CityMbarara City |
| 26 Nov 21 | r07        | Bright StarsBright Stars | 1 - 0 | Tooro UnitedTooro United |
| 26 Nov 21 | r07        | UPDFUPDF | 2 - 1 | Busoga UnitedBusoga United |
| 27 Nov 21 | r07        | VipersVipers | 0 - 2 | URAURA |
| 28 Nov 21 | r07        | BUL Jinja FCBUL Jinja FC | 1 - 1 | GaddafiGaddafi |
| |
| 30 Nov 21 | r08        | Mbarara CityMbarara City | 1 - 0 | SC VillaSC Villa |
| 30 Nov 21 | r08        | OnduparakaOnduparaka | 1 - 1 | ExpressExpress |
| 30 Nov 21 | r08        | Tooro UnitedTooro United | 2 - 4 | UPDFUPDF |
| 30 Nov 21 | r08        | URAURA | 0 - 0 | Uganda Police FCUganda Police |
| 30 Nov 21 | r08        | Wakiso GiantsWakiso Giants | 4 - 2 | Bright StarsBright Stars |
| 30 Nov 21 | r08        | Busoga UnitedBusoga United | 0 - 1 | Arua HillArua Hill |
| 01 Dec 21 | r08        | GaddafiGaddafi | 1 - 3 | VipersVipers |
| 01 Dec 21 | r08        | Kampala Capital City AuthKampala Capit | 3 - 1 | BUL Jinja FCBUL Jinja FC |
| |
| 05 Dec 21 | r09        | VipersVipers | 2 - 2 | Kampala Capital City AuthKampala Capit |
| 05 Dec 21 | r09        | Arua HillArua Hill | 3 - 1 | Tooro UnitedTooro United |
| 05 Dec 21 | r09        | UPDFUPDF | 2 - 1 | Bright StarsBright Stars |
| 07 Dec 21 | r09        | ExpressExpress | 2 - 0 | Mbarara CityMbarara City |
| 07 Dec 21 | r09        | OnduparakaOnduparaka | 1 - 1 | Wakiso GiantsWakiso Giants |
| 07 Dec 21 | r09        | Uganda Police FCUganda Police | 2 - 2 | GaddafiGaddafi |
| 07 Dec 21 | r09        | SC VillaSC Villa | 2 - 2 | URAURA |
| 07 Dec 21 | r09        | BUL Jinja FCBUL Jinja FC | 5 - 0 | Busoga UnitedBusoga United |
| |
| 10 Dec 21 | r10        | Kampala Capital City AuthKampala Capit | 3 - 1 | Uganda Police FCUganda Police |
| 10 Dec 21 | r10        | GaddafiGaddafi | 2 - 1 | SC VillaSC Villa |
| 10 Dec 21 | r10        | Tooro UnitedTooro United | 1 - 3 | BUL Jinja FCBUL Jinja FC |
| 10 Dec 21 | r10        | Bright StarsBright Stars | 0 - 0 | Arua HillArua Hill |
| 11 Dec 21 | r10        | URAURA | 0 - 0 | ExpressExpress |
| 11 Dec 21 | r10        | Mbarara CityMbarara City | 3 - 2 | OnduparakaOnduparaka |
| 11 Dec 21 | r10        | Wakiso GiantsWakiso Giants | 1 - 0 | UPDFUPDF |
| 11 Dec 21 | r10        | Busoga UnitedBusoga United | 1 - 4 | VipersVipers |
| |
| 14 Dec 21 | r02        | Arua HillArua Hill | 2 - 2 | SC VillaSC Villa |
| |
| 17 Dec 21 | r11        | OnduparakaOnduparaka | 1 - 1 | URAURA |
| 17 Dec 21 | r11        | BUL Jinja FCBUL Jinja FC | 0 - 0 | Bright StarsBright Stars |
| 17 Dec 21 | r11        | ExpressExpress | 1 - 0 | GaddafiGaddafi |
| 17 Dec 21 | r11        | Mbarara CityMbarara City | 0 - 0 | Wakiso GiantsWakiso Giants |
| 18 Dec 21 | r11        | SC VillaSC Villa | 1 - 1 | Kampala Capital City AuthKampala Capit |
| 18 Dec 21 | r11        | Arua HillArua Hill | 2 - 1 | UPDFUPDF |
| 18 Dec 21 | r11        | VipersVipers | 1 - 0 | Tooro UnitedTooro United |
| 18 Dec 21 | r11        | Uganda Police FCUganda Police | 3 - 1 | Busoga UnitedBusoga United |
| |
| 21 Dec 21 | r12        | Bright StarsBright Stars | 0 - 1 | VipersVipers |
| 21 Dec 21 | r12        | GaddafiGaddafi | 2 - 2 | OnduparakaOnduparaka |
| 21 Dec 21 | r12        | Tooro UnitedTooro United | 1 - 3 | Uganda Police FCUganda Police |
| 22 Dec 21 | r12        | Kampala Capital City AuthKampala Capit | 0 - 0 | ExpressExpress |
| 22 Dec 21 | r12        | UPDFUPDF | 1 - 1 | BUL Jinja FCBUL Jinja FC |
| 22 Dec 21 | r12        | URAURA | 2 - 0 | Mbarara CityMbarara City |
| 22 Dec 21 | r12        | Wakiso GiantsWakiso Giants | 1 - 2 | Arua HillArua Hill |
| 22 Dec 21 | r12        | Busoga UnitedBusoga United | 0 - 1 | SC VillaSC Villa |
| |
| 27 Dec 21 | r13        | SC VillaSC Villa | 4 - 0 | Tooro UnitedTooro United |
| 27 Dec 21 | r13        | VipersVipers | 7 - 2 | UPDFUPDF |