| 14 Aug 21 | r01        | Larkhall AthleticLarkhall Athl | 3 - 1 | SlimbridgeSlimbridge |
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| 28 Aug 21 | r03        | Frome TownFrome Town | 2 - 0 | SlimbridgeSlimbridge |
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| 30 Aug 21 | r04        | SlimbridgeSlimbridge | 3 - 3 | Cinderford TownCinderford To |
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| 04 Sep 21 | r02        | SlimbridgeSlimbridge | 0 - 4 | Winchester CityWinchester Ci |
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| 11 Sep 21 | r05        | SlimbridgeSlimbridge | 2 - 3 | Willand RoversWilland Rover |
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| 13 Sep 21 | r06        | Evesham UnitedEvesham Unite | 1 - 2 | SlimbridgeSlimbridge |
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| 18 Sep 21 | r14        | AFC TottonAFC Totton | 0 - 3 | SlimbridgeSlimbridge |
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| 25 Sep 21 | r07        | SholingSholing | 2 - 1 | SlimbridgeSlimbridge |
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| 02 Oct 21 | r09        | SlimbridgeSlimbridge | 0 - 5 | Melksham TownMelksham Town |
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| 16 Oct 21 | r10        | CirencesterCirencester | 6 - 0 | SlimbridgeSlimbridge |
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| 20 Oct 21 | r08        | SlimbridgeSlimbridge | 3 - 0 | Barnstaple TownBarnstaple To |
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| 23 Oct 21 | r11        | SlimbridgeSlimbridge | 3 - 0 | Lymington TownLymington Tow |
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| 30 Oct 21 | r15        | Winchester CityWinchester Ci | 4 - 0 | SlimbridgeSlimbridge |
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| 20 Nov 21 | r16        | SlimbridgeSlimbridge | 2 - 3 | Larkhall AthleticLarkhall Athl |
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| 24 Nov 21 | r12        | Paulton RoversPaulton Rover | 5 - 1 | SlimbridgeSlimbridge |
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| 27 Nov 21 | r17        | SlimbridgeSlimbridge | 1 - 0 | BidefordBideford |
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| 04 Dec 21 | r18        | Bristol Manor FarmBristol Manor | 0 - 0 | SlimbridgeSlimbridge |
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| 11 Dec 21 | r19        | SlimbridgeSlimbridge | 4 - 2 | Highworth TownHighworth Tow |
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| 01 Jan 22 | r22        | SlimbridgeSlimbridge | 3 - 5 | Mangotsfield UnitedMangotsfield |
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| 15 Jan 22 | r24        | Willand RoversWilland Rover | 3 - 0 | SlimbridgeSlimbridge |
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| 25 Jan 22 | r20        | Plymouth ParkwayPlymouth Park | 6 - 1 | SlimbridgeSlimbridge |
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| 29 Jan 22 | r26        | Barnstaple TownBarnstaple To | 3 - 2 | SlimbridgeSlimbridge |
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| 02 Feb 22 | r23        | SlimbridgeSlimbridge | 2 - 0 | Evesham UnitedEvesham Unite |
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| 05 Feb 22 | r27        | Melksham TownMelksham Town | 2 - 1 | SlimbridgeSlimbridge |
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| 08 Feb 22 | r21        | Cinderford TownCinderford To | 1 - 2 | SlimbridgeSlimbridge |
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| 12 Feb 22 | r28        | SlimbridgeSlimbridge | 3 - 2 | CirencesterCirencester |
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| 19 Feb 22 | r29        | Lymington TownLymington Tow | 2 - 3 | SlimbridgeSlimbridge |
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| 26 Feb 22 | r30        | SlimbridgeSlimbridge | 3 - 3 | Paulton RoversPaulton Rover |
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| 05 Mar 22 | r31        | SlimbridgeSlimbridge | 1 - 1 | Bristol Manor FarmBristol Manor |
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| 19 Mar 22 | r32        | BidefordBideford | 2 - 0 | SlimbridgeSlimbridge |
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| 26 Mar 22 | r33        | SlimbridgeSlimbridge | 1 - 3 | Plymouth ParkwayPlymouth Park |
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| 02 Apr 22 | r34        | Highworth TownHighworth Tow | 0 - 0 | SlimbridgeSlimbridge |
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| 12 Apr 22 | r25        | SlimbridgeSlimbridge | 3 - 0 | SholingSholing |
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| 16 Apr 22 | r36        | SlimbridgeSlimbridge | 0 - 1 | Frome TownFrome Town |
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| 18 Apr 22 | r37        | Mangotsfield UnitedMangotsfield | 2 - 0 | SlimbridgeSlimbridge |
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| 23 Apr 22 | r38        | SlimbridgeSlimbridge | 1 - 3 | AFC TottonAFC Totton |