| 14 Aug 21 | r01        | AFC TottonAFC Totton | 1 - 0 | Plymouth ParkwayPlymouth Park |
| 14 Aug 21 | r01        | Barnstaple TownBarnstaple To | 1 - 3 | Lymington TownLymington Tow |
| 14 Aug 21 | r01        | Cinderford TownCinderford To | 2 - 4 | Paulton RoversPaulton Rover |
| 14 Aug 21 | r01        | CirencesterCirencester | 3 - 2 | Bristol Manor FarmBristol Manor |
| 14 Aug 21 | r01        | Frome TownFrome Town | 1 - 0 | Highworth TownHighworth Tow |
| 14 Aug 21 | r01        | Larkhall AthleticLarkhall Athl | 3 - 1 | SlimbridgeSlimbridge |
| 14 Aug 21 | r01        | Mangotsfield UnitedMangotsfield | 0 - 2 | SholingSholing |
| 14 Aug 21 | r01        | Willand RoversWilland Rover | 3 - 1 | Melksham TownMelksham Town |
| 14 Aug 21 | r01        | Winchester CityWinchester Ci | 2 - 2 | BidefordBideford |
| |
| 16 Aug 21 | r02        | Evesham UnitedEvesham Unite | 2 - 1 | Mangotsfield UnitedMangotsfield |
| 16 Aug 21 | r02        | SholingSholing | 0 - 0 | Larkhall AthleticLarkhall Athl |
| 17 Aug 21 | r02        | Bristol Manor FarmBristol Manor | 3 - 1 | Barnstaple TownBarnstaple To |
| 17 Aug 21 | r02        | Melksham TownMelksham Town | 0 - 1 | AFC TottonAFC Totton |
| 17 Aug 21 | r02        | Plymouth ParkwayPlymouth Park | 2 - 2 | Frome TownFrome Town |
| 17 Aug 21 | r02        | CirencesterCirencester | 3 - 0 | Lymington TownLymington Tow |
| 18 Aug 21 | r02        | Paulton RoversPaulton Rover | 3 - 2 | Willand RoversWilland Rover |
| 18 Aug 21 | r02        | Highworth TownHighworth Tow | 2 - 1 | Cinderford TownCinderford To |
| |
| 28 Aug 21 | r03        | AFC TottonAFC Totton | 3 - 1 | Highworth TownHighworth Tow |
| 28 Aug 21 | r03        | Barnstaple TownBarnstaple To | 0 - 2 | Melksham TownMelksham Town |
| 28 Aug 21 | r03        | Cinderford TownCinderford To | 3 - 3 | Lymington TownLymington Tow |
| 28 Aug 21 | r03        | CirencesterCirencester | 1 - 1 | BidefordBideford |
| 28 Aug 21 | r03        | Frome TownFrome Town | 2 - 0 | SlimbridgeSlimbridge |
| 28 Aug 21 | r03        | Larkhall AthleticLarkhall Athl | 2 - 2 | Bristol Manor FarmBristol Manor |
| 28 Aug 21 | r03        | Mangotsfield UnitedMangotsfield | 0 - 6 | Plymouth ParkwayPlymouth Park |
| 28 Aug 21 | r03        | Willand RoversWilland Rover | 1 - 2 | SholingSholing |
| 28 Aug 21 | r03        | Winchester CityWinchester Ci | 2 - 0 | Evesham UnitedEvesham Unite |
| |
| 30 Aug 21 | r04        | BidefordBideford | 1 - 0 | Barnstaple TownBarnstaple To |
| 30 Aug 21 | r04        | Bristol Manor FarmBristol Manor | 2 - 0 | Mangotsfield UnitedMangotsfield |
| 30 Aug 21 | r04        | Evesham UnitedEvesham Unite | 0 - 3 | CirencesterCirencester |
| 30 Aug 21 | r04        | Melksham TownMelksham Town | 0 - 3 | Frome TownFrome Town |
| 30 Aug 21 | r04        | Paulton RoversPaulton Rover | 0 - 0 | Larkhall AthleticLarkhall Athl |
| 30 Aug 21 | r04        | Plymouth ParkwayPlymouth Park | 4 - 1 | Willand RoversWilland Rover |
| 30 Aug 21 | r04        | SholingSholing | 2 - 0 | Winchester CityWinchester Ci |
| 30 Aug 21 | r04        | SlimbridgeSlimbridge | 3 - 3 | Cinderford TownCinderford To |
| 31 Aug 21 | r04        | Lymington TownLymington Tow | 0 - 4 | AFC TottonAFC Totton |
| |
| 04 Sep 21 | r02        | SlimbridgeSlimbridge | 0 - 4 | Winchester CityWinchester Ci |
| |
| 04 Sep 21 | r08        | Paulton RoversPaulton Rover | 1 - 2 | Evesham UnitedEvesham Unite |
| |
| 04 Sep 21 | r32        | Bristol Manor FarmBristol Manor | 2 - 2 | AFC TottonAFC Totton |
| |
| 11 Sep 21 | r05        | BidefordBideford | 0 - 3 | SholingSholing |
| 11 Sep 21 | r05        | Bristol Manor FarmBristol Manor | 1 - 3 | Melksham TownMelksham Town |
| 11 Sep 21 | r05        | Cinderford TownCinderford To | 1 - 8 | AFC TottonAFC Totton |
| 11 Sep 21 | r05        | CirencesterCirencester | 1 - 1 | Frome TownFrome Town |
| 11 Sep 21 | r05        | Lymington TownLymington Tow | 3 - 1 | Evesham UnitedEvesham Unite |
| 11 Sep 21 | r05        | Mangotsfield UnitedMangotsfield | 1 - 4 | Larkhall AthleticLarkhall Athl |
| 11 Sep 21 | r05        | Paulton RoversPaulton Rover | 2 - 3 | Highworth TownHighworth Tow |
| 11 Sep 21 | r05        | SlimbridgeSlimbridge | 2 - 3 | Willand RoversWilland Rover |
| 11 Sep 21 | r05        | Winchester CityWinchester Ci | 7 - 1 | Barnstaple TownBarnstaple To |
| |
| 13 Sep 21 | r06        | Evesham UnitedEvesham Unite | 1 - 2 | SlimbridgeSlimbridge |
| 14 Sep 21 | r06        | SholingSholing | 3 - 1 | Lymington TownLymington Tow |
| 14 Sep 21 | r06        | AFC TottonAFC Totton | 2 - 2 | Winchester CityWinchester Ci |
| 14 Sep 21 | r06        | Melksham TownMelksham Town | 1 - 1 | CirencesterCirencester |
| 14 Sep 21 | r06        | Plymouth ParkwayPlymouth Park | 4 - 0 | BidefordBideford |
| 15 Sep 21 | r06        | Willand RoversWilland Rover | 1 - 2 | Bristol Manor FarmBristol Manor |
| |
| 18 Sep 21 | r07        | Barnstaple TownBarnstaple To | 0 - 7 | Cinderford TownCinderford To |
| 18 Sep 21 | r07        | Evesham UnitedEvesham Unite | 1 - 1 | Bristol Manor FarmBristol Manor |
| 18 Sep 21 | r07        | Highworth TownHighworth Tow | 4 - 1 | BidefordBideford |
| 18 Sep 21 | r07        | Plymouth ParkwayPlymouth Park | 5 - 1 | Paulton RoversPaulton Rover |
| 18 Sep 21 | r07        | Willand RoversWilland Rover | 1 - 1 | Mangotsfield UnitedMangotsfield |
| |
| 18 Sep 21 | r14        | AFC TottonAFC Totton | 0 - 3 | SlimbridgeSlimbridge |
| |
| 25 Sep 21 | r06        | Barnstaple TownBarnstaple To | 1 - 5 | Paulton RoversPaulton Rover |
| 25 Sep 21 | r06        | Highworth TownHighworth Tow | 2 - 0 | Mangotsfield UnitedMangotsfield |
| 25 Sep 21 | r06        | Larkhall AthleticLarkhall Athl | 3 - 3 | Cinderford TownCinderford To |
| |
| 25 Sep 21 | r07        | SholingSholing | 2 - 1 | SlimbridgeSlimbridge |
| |
| 25 Sep 21 | r14        | Frome TownFrome Town | 2 - 0 | Lymington TownLymington Tow |
| |
| 28 Sep 21 | r08        | Bristol Manor FarmBristol Manor | 4 - 2 | Plymouth ParkwayPlymouth Park |
| 28 Sep 21 | r08        | Cinderford TownCinderford To | 1 - 0 | Melksham TownMelksham Town |
| 28 Sep 21 | r08        | CirencesterCirencester | 1 - 0 | SholingSholing |
| 28 Sep 21 | r08        | Mangotsfield UnitedMangotsfield | 0 - 5 | AFC TottonAFC Totton |
| |
| 02 Oct 21 | r09        | BidefordBideford | 0 - 2 | Paulton RoversPaulton Rover |
| 02 Oct 21 | r09        | Bristol Manor FarmBristol Manor | 0 - 0 | Lymington TownLymington Tow |
| 02 Oct 21 | r09        | Evesham UnitedEvesham Unite | 1 - 4 | Willand RoversWilland Rover |
| 02 Oct 21 | r09        | Larkhall AthleticLarkhall Athl | 9 - 1 | Barnstaple TownBarnstaple To |
| 02 Oct 21 | r09        | Mangotsfield UnitedMangotsfield | 3 - 1 | Cinderford TownCinderford To |
| 02 Oct 21 | r09        | SlimbridgeSlimbridge | 0 - 5 | Melksham TownMelksham Town |
| |
| 16 Oct 21 | r10        | Barnstaple TownBarnstaple To | 1 - 8 | AFC TottonAFC Totton |
| 16 Oct 21 | r10        | Cinderford TownCinderford To | 2 - 5 | Winchester CityWinchester Ci |
| 16 Oct 21 | r10        | CirencesterCirencester | 6 - 0 | SlimbridgeSlimbridge |
| 16 Oct 21 | r10        | Frome TownFrome Town | 3 - 2 | SholingSholing |
| 16 Oct 21 | r10        | Highworth TownHighworth Tow | 5 - 1 | Evesham UnitedEvesham Unite |
| 16 Oct 21 | r10        | Lymington TownLymington Tow | 2 - 1 | BidefordBideford |
| 16 Oct 21 | r10        | Melksham TownMelksham Town | 4 - 3 | Plymouth ParkwayPlymouth Park |
| 16 Oct 21 | r10        | Paulton RoversPaulton Rover | 1 - 3 | Bristol Manor FarmBristol Manor |
| 16 Oct 21 | r10        | Willand RoversWilland Rover | 1 - 0 | Larkhall AthleticLarkhall Athl |
| |
| 19 Oct 21 | r08        | Winchester CityWinchester Ci | 0 - 1 | Highworth TownHighworth Tow |
| 20 Oct 21 | r08        | SlimbridgeSlimbridge | 3 - 0 | Barnstaple TownBarnstaple To |
| |
| 23 Oct 21 | r11        | Barnstaple TownBarnstaple To | 1 - 5 | CirencesterCirencester |
| 23 Oct 21 | r11        | Bristol Manor FarmBristol Manor | 0 - 2 | BidefordBideford |
| 23 Oct 21 | r11        | Cinderford TownCinderford To | 2 - 3 | Frome TownFrome Town |
| 23 Oct 21 | r11        | Evesham UnitedEvesham Unite | 3 - 1 | Plymouth ParkwayPlymouth Park |
| 23 Oct 21 | r11        | Larkhall AthleticLarkhall Athl | 1 - 0 | Highworth TownHighworth Tow |
| 23 Oct 21 | r11        | Mangotsfield UnitedMangotsfield | 0 - 2 | Melksham TownMelksham Town |
| 23 Oct 21 | r11        | SholingSholing | 0 - 2 | Paulton RoversPaulton Rover |
| 23 Oct 21 | r11        | SlimbridgeSlimbridge | 3 - 0 | Lymington TownLymington Tow |
| 23 Oct 21 | r11        | Winchester CityWinchester Ci | 1 - 1 | Willand RoversWilland Rover |
| |
| 26 Oct 21 | r07        | Frome TownFrome Town | 2 - 0 | Winchester CityWinchester Ci |
| |
| 26 Oct 21 | r08        | Lymington TownLymington Tow | 1 - 1 | Larkhall AthleticLarkhall Athl |
| |
| 30 Oct 21 | r12        | BidefordBideford | 0 - 1 | Evesham UnitedEvesham Unite |
| 30 Oct 21 | r12        | Highworth TownHighworth Tow | 1 - 2 | Bristol Manor FarmBristol Manor |
| 30 Oct 21 | r12        | Lymington TownLymington Tow | 3 - 0 | Mangotsfield UnitedMangotsfield |
| |
| 30 Oct 21 | r15        | Winchester CityWinchester Ci | 4 - 0 | SlimbridgeSlimbridge |