| 14 Aug 21 | r01  | CirencesterCirencester | 3 - 2 | Bristol Manor FarmBristol Manor |
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| 17 Aug 21 | r02 | Bristol Manor FarmBristol Manor | 3 - 1 | Barnstaple TownBarnstaple To |
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| 28 Aug 21 | r03 | Larkhall AthleticLarkhall Athl | 2 - 2 | Bristol Manor FarmBristol Manor |
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| 30 Aug 21 | r04 | Bristol Manor FarmBristol Manor | 2 - 0 | Mangotsfield UnitedMangotsfield |
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| 04 Sep 21 | r32 | Bristol Manor FarmBristol Manor | 2 - 2 | AFC TottonAFC Totton |
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| 11 Sep 21 | r05 | Bristol Manor FarmBristol Manor | 1 - 3 | Melksham TownMelksham Town |
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| 15 Sep 21 | r06 | Willand RoversWilland Rover | 1 - 2 | Bristol Manor FarmBristol Manor |
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| 18 Sep 21 | r07 | Evesham UnitedEvesham Unite | 1 - 1 | Bristol Manor FarmBristol Manor |
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| 28 Sep 21 | r08 | Bristol Manor FarmBristol Manor | 4 - 2 | Plymouth ParkwayPlymouth Park |
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| 02 Oct 21 | r09 | Bristol Manor FarmBristol Manor | 0 - 0 | Lymington TownLymington Tow |
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| 16 Oct 21 | r10 | Paulton RoversPaulton Rover | 1 - 3 | Bristol Manor FarmBristol Manor |
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| 23 Oct 21 | r11 | Bristol Manor FarmBristol Manor | 0 - 2 | BidefordBideford |
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| 30 Oct 21 | r12 | Highworth TownHighworth Tow | 1 - 2 | Bristol Manor FarmBristol Manor |
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| 06 Nov 21 | r13 | Bristol Manor FarmBristol Manor | 0 - 3 | Frome TownFrome Town |
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| 13 Nov 21 | r14 | Winchester CityWinchester Ci | 5 - 1 | Bristol Manor FarmBristol Manor |
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| 16 Nov 21 | r15 | Barnstaple TownBarnstaple To | 4 - 5 | Bristol Manor FarmBristol Manor |
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| 20 Nov 21 | r16 | Bristol Manor FarmBristol Manor | 1 - 0 | CirencesterCirencester |
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| 04 Dec 21 | r18 | Bristol Manor FarmBristol Manor | 0 - 0 | SlimbridgeSlimbridge |
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| 11 Dec 21 | r19 | SholingSholing | 2 - 1 | Bristol Manor FarmBristol Manor |
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| 18 Dec 21 | r20 | Bristol Manor FarmBristol Manor | 0 - 0 | Cinderford TownCinderford To |
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| 27 Dec 21 | r21 | Mangotsfield UnitedMangotsfield | 0 - 3 | Bristol Manor FarmBristol Manor |
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| 15 Jan 22 | r24 | Melksham TownMelksham Town | 0 - 4 | Bristol Manor FarmBristol Manor |
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| 22 Jan 22 | r25 | Bristol Manor FarmBristol Manor | 2 - 1 | Evesham UnitedEvesham Unite |
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| 29 Jan 22 | r26 | Plymouth ParkwayPlymouth Park | 0 - 2 | Bristol Manor FarmBristol Manor |
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| 05 Feb 22 | r27 | Lymington TownLymington Tow | 1 - 2 | Bristol Manor FarmBristol Manor |
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| 12 Feb 22 | r28 | Bristol Manor FarmBristol Manor | 2 - 0 | Paulton RoversPaulton Rover |
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| 19 Feb 22 | r29 | BidefordBideford | 1 - 0 | Bristol Manor FarmBristol Manor |
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| 26 Feb 22 | r30 | Bristol Manor FarmBristol Manor | 4 - 0 | Highworth TownHighworth Tow |
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| 05 Mar 22 | r31 | SlimbridgeSlimbridge | 1 - 1 | Bristol Manor FarmBristol Manor |
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| 12 Mar 22 | r23 | Bristol Manor FarmBristol Manor | 2 - 0 | Willand RoversWilland Rover |
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| 19 Mar 22 | r17 | AFC TottonAFC Totton | 1 - 2 | Bristol Manor FarmBristol Manor |
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| 26 Mar 22 | r33 | Cinderford TownCinderford To | 1 - 2 | Bristol Manor FarmBristol Manor |
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| 02 Apr 22 | r34 | Bristol Manor FarmBristol Manor | 1 - 0 | SholingSholing |
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| 09 Apr 22 | r35 | Frome TownFrome Town | 0 - 0 | Bristol Manor FarmBristol Manor |
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| 16 Apr 22 | r36 | Bristol Manor FarmBristol Manor | 3 - 0 | Larkhall AthleticLarkhall Athl |
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| 23 Apr 22 | r38 | Bristol Manor FarmBristol Manor | 2 - 2 | Winchester CityWinchester Ci |
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