| 22 Aug 21 | r01  | VV HooglandVV Hoogland | 2 - 2 | VV GemertVV Gemert |
| 22 Aug 21 | r01 | ADO 20ADO 20 | 1 - 2 | OFC OostzaanOFC Oostzaan |
| 22 Aug 21 | r01 | VV DongenVV Dongen | 1 - 1 | JOS WatergraafsmeerJOS Watergraa |
| 22 Aug 21 | r01 | HVV HollandiaHVV Hollandia | 0 - 2 | VV UNAVV UNA |
| 22 Aug 21 | r01 | Quick Den HaagQuick Den Haa | 2 - 0 | RKVV WestlandiaRKVV Westland |
| 22 Aug 21 | r01 | Blauw Geel 38Blauw Geel 38 | 0 - 2 | SV OSS 20SV OSS 20 |
| 22 Aug 21 | r01 | HSC 21HSC 21 | 0 - 1 | RKVV EVVRKVV EVV |
| 22 Aug 21 | r01 | RKSV Groene SterRKSV Groene S | 3 - 0 | RKVV DEMRKVV DEM |
| |
| 29 Aug 21 | r02 | RKVV DEMRKVV DEM | 0 - 0 | VV HooglandVV Hoogland |
| 29 Aug 21 | r02 | RKVV WestlandiaRKVV Westland | 1 - 1 | USV HerculesUSV Hercules |
| 29 Aug 21 | r02 | JOS WatergraafsmeerJOS Watergraa | 1 - 0 | HVV HollandiaHVV Hollandia |
| 29 Aug 21 | r02 | GVV UnitasGVV Unitas | 0 - 0 | Quick Den HaagQuick Den Haa |
| 29 Aug 21 | r02 | VV GemertVV Gemert | 2 - 1 | VV DongenVV Dongen |
| 29 Aug 21 | r02 | RKVV EVVRKVV EVV | 2 - 4 | Blauw Geel 38Blauw Geel 38 |
| 29 Aug 21 | r02 | SV OSS 20SV OSS 20 | 5 - 1 | ADO 20ADO 20 |
| 29 Aug 21 | r02 | OFC OostzaanOFC Oostzaan | 2 - 1 | HSC 21HSC 21 |
| 29 Aug 21 | r02 | VV UNAVV UNA | 4 - 1 | RKSV Groene SterRKSV Groene S |
| |
| 05 Sep 21 | r03 | USV HerculesUSV Hercules | 3 - 1 | SV OSS 20SV OSS 20 |
| 05 Sep 21 | r03 | VV HooglandVV Hoogland | 0 - 4 | RKVV WestlandiaRKVV Westland |
| 05 Sep 21 | r03 | ADO 20ADO 20 | 3 - 0 | VV UNAVV UNA |
| 05 Sep 21 | r03 | VV DongenVV Dongen | 3 - 0 | RKVV DEMRKVV DEM |
| 05 Sep 21 | r03 | HVV HollandiaHVV Hollandia | 0 - 0 | RKVV EVVRKVV EVV |
| 05 Sep 21 | r03 | Quick Den HaagQuick Den Haa | 0 - 2 | OFC OostzaanOFC Oostzaan |
| 05 Sep 21 | r03 | Blauw Geel 38Blauw Geel 38 | 2 - 1 | GVV UnitasGVV Unitas |
| 05 Sep 21 | r03 | HSC 21HSC 21 | 1 - 5 | JOS WatergraafsmeerJOS Watergraa |
| 05 Sep 21 | r03 | RKSV Groene SterRKSV Groene S | 3 - 3 | VV GemertVV Gemert |
| |
| 12 Sep 21 | r04 | ADO 20ADO 20 | 2 - 3 | RKSV Groene SterRKSV Groene S |
| 12 Sep 21 | r04 | RKVV WestlandiaRKVV Westland | 3 - 0 | Blauw Geel 38Blauw Geel 38 |
| 12 Sep 21 | r04 | JOS WatergraafsmeerJOS Watergraa | 1 - 4 | USV HerculesUSV Hercules |
| 12 Sep 21 | r04 | GVV UnitasGVV Unitas | 3 - 1 | VV HooglandVV Hoogland |
| 12 Sep 21 | r04 | VV GemertVV Gemert | 3 - 0 | HVV HollandiaHVV Hollandia |
| 12 Sep 21 | r04 | RKVV EVVRKVV EVV | 1 - 1 | RKVV DEMRKVV DEM |
| 12 Sep 21 | r04 | SV OSS 20SV OSS 20 | 1 - 0 | Quick Den HaagQuick Den Haa |
| 12 Sep 21 | r04 | OFC OostzaanOFC Oostzaan | 2 - 1 | VV DongenVV Dongen |
| 12 Sep 21 | r04 | VV UNAVV UNA | 3 - 1 | HSC 21HSC 21 |
| |
| 19 Sep 21 | r05 | USV HerculesUSV Hercules | 4 - 1 | VV UNAVV UNA |
| 19 Sep 21 | r05 | VV HooglandVV Hoogland | 0 - 0 | RKVV EVVRKVV EVV |
| 19 Sep 21 | r05 | VV DongenVV Dongen | 1 - 1 | HSC 21HSC 21 |
| 19 Sep 21 | r05 | HVV HollandiaHVV Hollandia | 1 - 1 | OFC OostzaanOFC Oostzaan |
| 19 Sep 21 | r05 | Quick Den HaagQuick Den Haa | 1 - 0 | JOS WatergraafsmeerJOS Watergraa |
| 19 Sep 21 | r05 | Blauw Geel 38Blauw Geel 38 | 0 - 2 | ADO 20ADO 20 |
| 19 Sep 21 | r05 | RKVV DEMRKVV DEM | 1 - 2 | VV GemertVV Gemert |
| 19 Sep 21 | r05 | GVV UnitasGVV Unitas | 4 - 2 | SV OSS 20SV OSS 20 |
| 19 Sep 21 | r05 | RKSV Groene SterRKSV Groene S | 0 - 0 | RKVV WestlandiaRKVV Westland |
| |
| 26 Sep 21 | r06 | ADO 20ADO 20 | 4 - 2 | USV HerculesUSV Hercules |
| 26 Sep 21 | r06 | RKVV WestlandiaRKVV Westland | 3 - 4 | GVV UnitasGVV Unitas |
| 26 Sep 21 | r06 | JOS WatergraafsmeerJOS Watergraa | 2 - 0 | RKVV DEMRKVV DEM |
| 26 Sep 21 | r06 | VV GemertVV Gemert | 0 - 0 | Blauw Geel 38Blauw Geel 38 |
| 26 Sep 21 | r06 | HSC 21HSC 21 | 2 - 2 | HVV HollandiaHVV Hollandia |
| 26 Sep 21 | r06 | RKVV EVVRKVV EVV | 1 - 1 | VV DongenVV Dongen |
| 26 Sep 21 | r06 | SV OSS 20SV OSS 20 | 2 - 0 | RKSV Groene SterRKSV Groene S |
| 26 Sep 21 | r06 | OFC OostzaanOFC Oostzaan | 4 - 0 | VV HooglandVV Hoogland |
| 26 Sep 21 | r06 | VV UNAVV UNA | 2 - 1 | Quick Den HaagQuick Den Haa |
| |
| 02 Oct 21 | r07 | Blauw Geel 38Blauw Geel 38 | 3 - 2 | VV UNAVV UNA |
| 03 Oct 21 | r07 | VV HooglandVV Hoogland | 3 - 1 | JOS WatergraafsmeerJOS Watergraa |
| 03 Oct 21 | r07 | Quick Den HaagQuick Den Haa | 3 - 1 | VV DongenVV Dongen |
| 03 Oct 21 | r07 | RKVV DEMRKVV DEM | 0 - 2 | HVV HollandiaHVV Hollandia |
| 03 Oct 21 | r07 | RKVV WestlandiaRKVV Westland | 1 - 1 | VV GemertVV Gemert |
| 03 Oct 21 | r07 | GVV UnitasGVV Unitas | 1 - 0 | ADO 20ADO 20 |
| 03 Oct 21 | r07 | RKSV Groene SterRKSV Groene S | 3 - 1 | OFC OostzaanOFC Oostzaan |
| 03 Oct 21 | r07 | SV OSS 20SV OSS 20 | 1 - 0 | RKVV EVVRKVV EVV |
| |
| 10 Oct 21 | r08 | ADO 20ADO 20 | 3 - 0 | RKVV WestlandiaRKVV Westland |
| 10 Oct 21 | r08 | VV DongenVV Dongen | 2 - 1 | Blauw Geel 38Blauw Geel 38 |
| 10 Oct 21 | r08 | HVV HollandiaHVV Hollandia | 3 - 0 | RKSV Groene SterRKSV Groene S |
| 10 Oct 21 | r08 | JOS WatergraafsmeerJOS Watergraa | 3 - 3 | SV OSS 20SV OSS 20 |
| 10 Oct 21 | r08 | VV GemertVV Gemert | 2 - 2 | USV HerculesUSV Hercules |
| 10 Oct 21 | r08 | HSC 21HSC 21 | 4 - 1 | VV HooglandVV Hoogland |
| 10 Oct 21 | r08 | RKVV EVVRKVV EVV | 1 - 0 | Quick Den HaagQuick Den Haa |
| 10 Oct 21 | r08 | OFC OostzaanOFC Oostzaan | 3 - 1 | RKVV DEMRKVV DEM |
| 10 Oct 21 | r08 | VV UNAVV UNA | 3 - 2 | GVV UnitasGVV Unitas |
| |
| 17 Oct 21 | r09 | USV HerculesUSV Hercules | 3 - 0 | RKVV EVVRKVV EVV |
| 17 Oct 21 | r09 | VV HooglandVV Hoogland | 0 - 1 | VV DongenVV Dongen |
| 17 Oct 21 | r09 | Quick Den HaagQuick Den Haa | 0 - 1 | ADO 20ADO 20 |
| 17 Oct 21 | r09 | Blauw Geel 38Blauw Geel 38 | 2 - 3 | OFC OostzaanOFC Oostzaan |
| 17 Oct 21 | r09 | RKVV DEMRKVV DEM | 0 - 3 | HSC 21HSC 21 |
| 17 Oct 21 | r09 | RKVV WestlandiaRKVV Westland | 0 - 3 | VV UNAVV UNA |
| 17 Oct 21 | r09 | GVV UnitasGVV Unitas | 0 - 3 | VV GemertVV Gemert |
| 17 Oct 21 | r09 | RKSV Groene SterRKSV Groene S | 1 - 0 | JOS WatergraafsmeerJOS Watergraa |
| 17 Oct 21 | r09 | SV OSS 20SV OSS 20 | 3 - 1 | HVV HollandiaHVV Hollandia |
| |
| 24 Oct 21 | r01 | USV HerculesUSV Hercules | 0 - 1 | GVV UnitasGVV Unitas |
| |
| 24 Oct 21 | r10 | HSC 21HSC 21 | 4 - 2 | Blauw Geel 38Blauw Geel 38 |
| 30 Oct 21 | r10 | RKVV EVVRKVV EVV | 0 - 0 | RKSV Groene SterRKSV Groene S |
| 31 Oct 21 | r10 | VV DongenVV Dongen | 2 - 1 | ADO 20ADO 20 |
| 31 Oct 21 | r10 | HVV HollandiaHVV Hollandia | 0 - 1 | VV HooglandVV Hoogland |
| 31 Oct 21 | r10 | RKVV DEMRKVV DEM | 1 - 0 | USV HerculesUSV Hercules |
| 31 Oct 21 | r10 | JOS WatergraafsmeerJOS Watergraa | 2 - 0 | GVV UnitasGVV Unitas |
| 31 Oct 21 | r10 | VV GemertVV Gemert | 4 - 2 | Quick Den HaagQuick Den Haa |
| 31 Oct 21 | r10 | OFC OostzaanOFC Oostzaan | 2 - 1 | RKVV WestlandiaRKVV Westland |
| 31 Oct 21 | r10 | VV UNAVV UNA | 3 - 1 | SV OSS 20SV OSS 20 |
| |
| 07 Nov 21 | r11 | USV HerculesUSV Hercules | 2 - 3 | OFC OostzaanOFC Oostzaan |
| 07 Nov 21 | r11 | Quick Den HaagQuick Den Haa | 0 - 2 | VV HooglandVV Hoogland |
| 07 Nov 21 | r11 | Blauw Geel 38Blauw Geel 38 | 4 - 0 | HVV HollandiaHVV Hollandia |
| 07 Nov 21 | r11 | RKVV WestlandiaRKVV Westland | 1 - 1 | RKVV EVVRKVV EVV |
| 07 Nov 21 | r11 | GVV UnitasGVV Unitas | 1 - 0 | HSC 21HSC 21 |
| 07 Nov 21 | r11 | SV OSS 20SV OSS 20 | 0 - 1 | RKVV DEMRKVV DEM |
| 07 Nov 21 | r11 | VV UNAVV UNA | 1 - 4 | JOS WatergraafsmeerJOS Watergraa |
| |
| 14 Nov 21 | r12 | VV HooglandVV Hoogland | 2 - 1 | Blauw Geel 38Blauw Geel 38 |
| 14 Nov 21 | r12 | VV DongenVV Dongen | 2 - 2 | USV HerculesUSV Hercules |
| 14 Nov 21 | r12 | HVV HollandiaHVV Hollandia | 2 - 0 | RKVV WestlandiaRKVV Westland |
| 14 Nov 21 | r12 | RKVV DEMRKVV DEM | 2 - 2 | Quick Den HaagQuick Den Haa |
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