| 04 Sep 21 | r51  | Atlético LevanteAtlético Leva | 2 - 0 | SocuéllamosSocuéllamos |
| 04 Sep 21 | r51 | HerculesHercules | 1 - 1 | Recreativo GranadaRecreativo Gr |
| 05 Sep 21 | r51 | MelillaMelilla | 1 - 0 | CD ToledoCD Toledo |
| 05 Sep 21 | r51 | MurciaMurcia | 3 - 2 | CD MarchamaloCD Marchamalo |
| 05 Sep 21 | r51 | ÁguilasÁguilas | 1 - 1 | Mancha RealMancha Real |
| 05 Sep 21 | r51  | EldenseEldense | 0 - 0 | CF IntercityCF Intercity |
| 05 Sep 21 | r51 | La NucíaLa Nucía | 1 - 0 | Mar MenorMar Menor |
| 05 Sep 21 | r51 | El EjidoEl Ejido | 1 - 1 | AlziraAlzira |
| 05 Sep 21 | r51 | Calvo SoteloCalvo Sotelo | 2 - 0 | CA PulpileñoCA Pulpileño |
| |
| 11 Sep 21 | r52 | Recreativo GranadaRecreativo Gr | 0 - 0 | MurciaMurcia |
| 12 Sep 21 | r52 | CD MarchamaloCD Marchamalo | 0 - 0 | MelillaMelilla |
| 12 Sep 21 | r52 | SocuéllamosSocuéllamos | 1 - 3 | El EjidoEl Ejido |
| 12 Sep 21 | r52 | CD ToledoCD Toledo | 0 - 1 | ÁguilasÁguilas |
| 12 Sep 21 | r52 | CA PulpileñoCA Pulpileño | 1 - 0 | Atlético LevanteAtlético Leva |
| 12 Sep 21 | r52 | Mancha RealMancha Real | 2 - 0 | Calvo SoteloCalvo Sotelo |
| 12 Sep 21 | r52 | CF IntercityCF Intercity | 1 - 2 | HerculesHercules |
| 12 Sep 21 | r52 | Mar MenorMar Menor | 1 - 1 | EldenseEldense |
| 12 Sep 21 | r52 | AlziraAlzira | 2 - 2 | La NucíaLa Nucía |
| |
| 18 Sep 21 | r53 | MelillaMelilla | 1 - 3 | Recreativo GranadaRecreativo Gr |
| 18 Sep 21 | r53 | HerculesHercules | 2 - 1 | Mar MenorMar Menor |
| 19 Sep 21 | r53 | MurciaMurcia | 2 - 0 | CF IntercityCF Intercity |
| 19 Sep 21 | r53 | La NucíaLa Nucía | 0 - 0 | SocuéllamosSocuéllamos |
| 19 Sep 21 | r53 | El EjidoEl Ejido | 0 - 1 | CA PulpileñoCA Pulpileño |
| 19 Sep 21 | r53 | Mancha RealMancha Real | 2 - 0 | CD ToledoCD Toledo |
| 19 Sep 21 | r53 | ÁguilasÁguilas | 2 - 0 | CD MarchamaloCD Marchamalo |
| 19 Sep 21 | r53 | EldenseEldense | 1 - 1 | AlziraAlzira |
| 19 Sep 21 | r53 | Calvo SoteloCalvo Sotelo | 0 - 0 | Atlético LevanteAtlético Leva |
| |
| 25 Sep 21 | r54 | Atlético LevanteAtlético Leva | 0 - 0 | El EjidoEl Ejido |
| 25 Sep 21 | r54 | Recreativo GranadaRecreativo Gr | 0 - 2 | ÁguilasÁguilas |
| 26 Sep 21 | r54 | CF IntercityCF Intercity | 0 - 0 | MelillaMelilla |
| 26 Sep 21 | r54 | CD ToledoCD Toledo | 1 - 4 | Calvo SoteloCalvo Sotelo |
| 26 Sep 21 | r54 | CD MarchamaloCD Marchamalo | 0 - 0 | Mancha RealMancha Real |
| 26 Sep 21 | r54 | Mar MenorMar Menor | 1 - 0 | MurciaMurcia |
| 26 Sep 21 | r54 | SocuéllamosSocuéllamos | 1 - 1 | EldenseEldense |
| 26 Sep 21 | r54 | AlziraAlzira | 4 - 0 | HerculesHercules |
| 26 Sep 21 | r54 | CA PulpileñoCA Pulpileño | 1 - 4 | La NucíaLa Nucía |
| |
| 02 Oct 21 | r55 | HerculesHercules | 0 - 0 | SocuéllamosSocuéllamos |
| 03 Oct 21 | r55 | Mancha RealMancha Real | 0 - 2 | Recreativo GranadaRecreativo Gr |
| 03 Oct 21 | r55 | MelillaMelilla | 2 - 3 | Mar MenorMar Menor |
| 03 Oct 21 | r55 | La NucíaLa Nucía | 1 - 0 | Atlético LevanteAtlético Leva |
| 03 Oct 21 | r55 | CD ToledoCD Toledo | 3 - 2 | CD MarchamaloCD Marchamalo |
| 03 Oct 21 | r55 | MurciaMurcia | 1 - 0 | AlziraAlzira |
| 03 Oct 21 | r55 | Calvo SoteloCalvo Sotelo | 1 - 1 | El EjidoEl Ejido |
| 03 Oct 21 | r55 | EldenseEldense | 0 - 3 | CA PulpileñoCA Pulpileño |
| 03 Oct 21 | r55 | ÁguilasÁguilas | 1 - 2 | CF IntercityCF Intercity |
| |
| 09 Oct 21 | r56 | Atlético LevanteAtlético Leva | 1 - 1 | EldenseEldense |
| 10 Oct 21 | r56 | CF IntercityCF Intercity | 1 - 0 | Mancha RealMancha Real |
| 10 Oct 21 | r56 | SocuéllamosSocuéllamos | 0 - 0 | MurciaMurcia |
| 10 Oct 21 | r56 | Recreativo GranadaRecreativo Gr | 1 - 1 | CD ToledoCD Toledo |
| 10 Oct 21 | r56 | AlziraAlzira | 0 - 1 | MelillaMelilla |
| 10 Oct 21 | r56 | El EjidoEl Ejido | 0 - 2 | La NucíaLa Nucía |
| 10 Oct 21 | r56 | CD MarchamaloCD Marchamalo | 0 - 0 | Calvo SoteloCalvo Sotelo |
| 10 Oct 21 | r56 | Mar MenorMar Menor | 0 - 0 | ÁguilasÁguilas |
| 10 Oct 21 | r56 | CA PulpileñoCA Pulpileño | 0 - 4 | HerculesHercules |
| |
| 17 Oct 21 | r57 | MelillaMelilla | 3 - 1 | SocuéllamosSocuéllamos |
| 17 Oct 21 | r57 | Mancha RealMancha Real | 1 - 2 | Mar MenorMar Menor |
| 17 Oct 21 | r57 | CD MarchamaloCD Marchamalo | 0 - 1 | Recreativo GranadaRecreativo Gr |
| 17 Oct 21 | r57 | CD ToledoCD Toledo | 0 - 1 | CF IntercityCF Intercity |
| 17 Oct 21 | r57 | Calvo SoteloCalvo Sotelo | 1 - 2 | La NucíaLa Nucía |
| 17 Oct 21 | r57 | MurciaMurcia | 1 - 1 | CA PulpileñoCA Pulpileño |
| 17 Oct 21 | r57 | HerculesHercules | 0 - 3 | Atlético LevanteAtlético Leva |
| 17 Oct 21 | r57 | ÁguilasÁguilas | 2 - 2 | AlziraAlzira |
| 17 Oct 21 | r57 | EldenseEldense | 3 - 1 | El EjidoEl Ejido |
| |
| 24 Oct 21 | r58 | CF IntercityCF Intercity | 3 - 0 | CD MarchamaloCD Marchamalo |
| 24 Oct 21 | r58 | CA PulpileñoCA Pulpileño | 1 - 3 | MelillaMelilla |
| 24 Oct 21 | r58 | Atlético LevanteAtlético Leva | 1 - 1 | MurciaMurcia |
| 24 Oct 21 | r58 | El EjidoEl Ejido | 0 - 1 | HerculesHercules |
| 24 Oct 21 | r58 | Recreativo GranadaRecreativo Gr | 2 - 1 | Calvo SoteloCalvo Sotelo |
| 24 Oct 21 | r58 | SocuéllamosSocuéllamos | 1 - 3 | ÁguilasÁguilas |
| 24 Oct 21 | r58 | Mar MenorMar Menor | 2 - 0 | CD ToledoCD Toledo |
| 24 Oct 21 | r58 | La NucíaLa Nucía | 1 - 0 | EldenseEldense |
| 24 Oct 21 | r58 | AlziraAlzira | 0 - 0 | Mancha RealMancha Real |
| |
| 31 Oct 21 | r59 | MelillaMelilla | 1 - 0 | Atlético LevanteAtlético Leva |
| 31 Oct 21 | r59 | Recreativo GranadaRecreativo Gr | 3 - 3 | CF IntercityCF Intercity |
| 31 Oct 21 | r59 | Mancha RealMancha Real | 1 - 0 | SocuéllamosSocuéllamos |
| 31 Oct 21 | r59 | CD MarchamaloCD Marchamalo | 2 - 0 | Mar MenorMar Menor |
| 31 Oct 21 | r59 | MurciaMurcia | 1 - 1 | El EjidoEl Ejido |
| 31 Oct 21 | r59 | HerculesHercules | 0 - 0 | La NucíaLa Nucía |
| 31 Oct 21 | r59 | CD ToledoCD Toledo | 1 - 2 | AlziraAlzira |
| 31 Oct 21 | r59 | ÁguilasÁguilas | 0 - 0 | CA PulpileñoCA Pulpileño |
| 31 Oct 21 | r59 | Calvo SoteloCalvo Sotelo | 0 - 1 | EldenseEldense |
| |
| 06 Nov 21 | r510 | AlziraAlzira | 1 - 0 | CD MarchamaloCD Marchamalo |
| 07 Nov 21 | r510 | CF IntercityCF Intercity | 4 - 0 | Calvo SoteloCalvo Sotelo |
| 07 Nov 21 | r510 | El EjidoEl Ejido | 3 - 1 | MelillaMelilla |
| 07 Nov 21 | r510 | SocuéllamosSocuéllamos | 1 - 1 | CD ToledoCD Toledo |
| 07 Nov 21 | r510 | Atlético LevanteAtlético Leva | 2 - 0 | ÁguilasÁguilas |
| 07 Nov 21 | r510 | La NucíaLa Nucía | 1 - 2 | MurciaMurcia |
| 07 Nov 21 | r510 | Mar MenorMar Menor | 0 - 1 | Recreativo GranadaRecreativo Gr |
| 07 Nov 21 | r510 | CA PulpileñoCA Pulpileño | 2 - 0 | Mancha RealMancha Real |
| 07 Nov 21 | r510 | EldenseEldense | 2 - 2 | HerculesHercules |
| |
| 14 Nov 21 | r511 | CF IntercityCF Intercity | 3 - 0 | Mar MenorMar Menor |
| 14 Nov 21 | r511 | Recreativo GranadaRecreativo Gr | 0 - 1 | AlziraAlzira |
| 14 Nov 21 | r511 | MelillaMelilla | 1 - 0 | La NucíaLa Nucía |
| 14 Nov 21 | r511 | Mancha RealMancha Real | 0 - 1 | Atlético LevanteAtlético Leva |
| 14 Nov 21 | r511 | CD MarchamaloCD Marchamalo | 1 - 2 | SocuéllamosSocuéllamos |
| 14 Nov 21 | r511 | ÁguilasÁguilas | 0 - 1 | El EjidoEl Ejido |
| 14 Nov 21 | r511 | MurciaMurcia | 1 - 2 | EldenseEldense |
| 14 Nov 21 | r511 | Calvo SoteloCalvo Sotelo | 2 - 1 | HerculesHercules |
| 14 Nov 21 | r511 | CD ToledoCD Toledo | 0 - 1 | CA PulpileñoCA Pulpileño |
| |
| 21 Nov 21 | r512 | SocuéllamosSocuéllamos | 1 - 1 | Recreativo GranadaRecreativo Gr |
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