| 05 May 21 | r00  | Buffalo BisonsBuffalo Bison | 6 - 1 | Worcester Red SoxWorcester Red |
| 06 May 21 | r00 | Buffalo BisonsBuffalo Bison | 5 - 2 | Worcester Red SoxWorcester Red |
| 07 May 21 | r00 | Buffalo BisonsBuffalo Bison | 10 - 1 | Worcester Red SoxWorcester Red |
| 08 May 21 | r00 | Buffalo BisonsBuffalo Bison | 2 - 4 | Worcester Red SoxWorcester Red |
| 08 May 21 | r00 | Buffalo BisonsBuffalo Bison | 6 - 8 | Worcester Red SoxWorcester Red |
| 09 May 21 | r00 | Buffalo BisonsBuffalo Bison | 4 - 1 | Worcester Red SoxWorcester Red |
| 12 May 21 | r00 | Buffalo BisonsBuffalo Bison | 3 - 6 | Rochester Red WingsRochester Red |
| 13 May 21 | r00 | Buffalo BisonsBuffalo Bison | 12 - 0 | Rochester Red WingsRochester Red |
| 14 May 21 | r00 | Buffalo BisonsBuffalo Bison | 3 - 1 | Rochester Red WingsRochester Red |
| 15 May 21 | r00 | Buffalo BisonsBuffalo Bison | 5 - 2 | Rochester Red WingsRochester Red |
| 15 May 21 | r00 | Buffalo BisonsBuffalo Bison | 7 - 3 | Rochester Red WingsRochester Red |
| 16 May 21 | r00 | Buffalo BisonsBuffalo Bison | 2 - 1 | Rochester Red WingsRochester Red |
| 18 May 21 | r00 | Worcester Red SoxWorcester Red | 9 - 4 | Buffalo BisonsBuffalo Bison |
| 19 May 21 | r00 | Worcester Red SoxWorcester Red | 1 - 4 | Buffalo BisonsBuffalo Bison |
| 20 May 21 | r00 | Worcester Red SoxWorcester Red | 4 - 1 | Buffalo BisonsBuffalo Bison |
| 21 May 21 | r00 | Worcester Red SoxWorcester Red | 4 - 6 | Buffalo BisonsBuffalo Bison |
| 22 May 21 | r00 | Worcester Red SoxWorcester Red | 7 - 4 | Buffalo BisonsBuffalo Bison |
| 23 May 21 | r00 | Worcester Red SoxWorcester Red | 4 - 0 | Buffalo BisonsBuffalo Bison |
| 25 May 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | 2 - 5 | Buffalo BisonsBuffalo Bison |
| 27 May 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | 4 - 2 | Buffalo BisonsBuffalo Bison |
| 27 May 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | 3 - 2 | Buffalo BisonsBuffalo Bison |
| 29 May 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | 3 - 2 | Buffalo BisonsBuffalo Bison |
| 02 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 3 - 2 | Syracuse MetsSyracuse Mets |
| 03 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 4 - 6 | Syracuse MetsSyracuse Mets |
| 04 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 5 - 4 | Syracuse MetsSyracuse Mets |
| 05 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 3 - 6 | Syracuse MetsSyracuse Mets |
| 05 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 6 - 7 | Syracuse MetsSyracuse Mets |
| 06 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 5 - 2 | Syracuse MetsSyracuse Mets |
| 09 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 5 - 7 | Scranton-Wilkes-Barre RaiScranton-Wilk |
| 10 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 2 - 3 | Scranton-Wilkes-Barre RaiScranton-Wilk |
| 11 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 10 - 0 | Scranton-Wilkes-Barre RaiScranton-Wilk |
| 12 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 4 - 2 | Scranton-Wilkes-Barre RaiScranton-Wilk |
| 12 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 4 - 6 | Scranton-Wilkes-Barre RaiScranton-Wilk |
| 13 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 0 - 8 | Scranton-Wilkes-Barre RaiScranton-Wilk |
| 16 Jun 21 | r00 | Rochester Red WingsRochester Red | 1 - 14 | Buffalo BisonsBuffalo Bison |
| 17 Jun 21 | r00 | Rochester Red WingsRochester Red | 2 - 0 | Buffalo BisonsBuffalo Bison |
| 17 Jun 21 | r00 | Rochester Red WingsRochester Red | 2 - 5 | Buffalo BisonsBuffalo Bison |
| 19 Jun 21 | r00 | Rochester Red WingsRochester Red | 0 - 5 | Buffalo BisonsBuffalo Bison |
| 20 Jun 21 | r00 | Rochester Red WingsRochester Red | 6 - 8 | Buffalo BisonsBuffalo Bison |
| 20 Jun 21 | r00 | Rochester Red WingsRochester Red | 1 - 7 | Buffalo BisonsBuffalo Bison |
| 23 Jun 21 | r00 | Syracuse MetsSyracuse Mets | 3 - 4 | Buffalo BisonsBuffalo Bison |
| 24 Jun 21 | r00 | Syracuse MetsSyracuse Mets | 5 - 8 | Buffalo BisonsBuffalo Bison |
| 25 Jun 21 | r00 | Syracuse MetsSyracuse Mets | 4 - 5 | Buffalo BisonsBuffalo Bison |
| 25 Jun 21 | r00 | Syracuse MetsSyracuse Mets | 9 - 8 | Buffalo BisonsBuffalo Bison |
| 26 Jun 21 | r00 | Syracuse MetsSyracuse Mets | 3 - 5 | Buffalo BisonsBuffalo Bison |
| 27 Jun 21 | r00 | Syracuse MetsSyracuse Mets | 7 - 9 | Buffalo BisonsBuffalo Bison |
| 30 Jun 21 | r00 | Buffalo BisonsBuffalo Bison | 12 - 2 | Lehigh Valley IronPigsLehigh Valley |
| 01 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 10 - 9 | Lehigh Valley IronPigsLehigh Valley |
| 02 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 5 - 2 | Lehigh Valley IronPigsLehigh Valley |
| 03 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 4 - 5 | Lehigh Valley IronPigsLehigh Valley |
| 04 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 0 - 4 | Lehigh Valley IronPigsLehigh Valley |
| 04 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 5 - 4 | Lehigh Valley IronPigsLehigh Valley |
| 07 Jul 21 | r00 | Rochester Red WingsRochester Red | 2 - 3 | Buffalo BisonsBuffalo Bison |
| 08 Jul 21 | r00 | Rochester Red WingsRochester Red | 4 - 3 | Buffalo BisonsBuffalo Bison |
| 09 Jul 21 | r00 | Rochester Red WingsRochester Red | 2 - 4 | Buffalo BisonsBuffalo Bison |
| 10 Jul 21 | r00 | Rochester Red WingsRochester Red | 7 - 3 | Buffalo BisonsBuffalo Bison |
| 11 Jul 21 | r00 | Rochester Red WingsRochester Red | 4 - 3 | Buffalo BisonsBuffalo Bison |
| 14 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 2 - 1 | Lehigh Valley IronPigsLehigh Valley |
| 15 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 9 - 2 | Lehigh Valley IronPigsLehigh Valley |
| 16 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 6 - 5 | Lehigh Valley IronPigsLehigh Valley |
| 17 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 4 - 3 | Lehigh Valley IronPigsLehigh Valley |
| 18 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 2 - 12 | Lehigh Valley IronPigsLehigh Valley |
| 18 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 4 - 0 | Lehigh Valley IronPigsLehigh Valley |
| 21 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 14 - 1 | Syracuse MetsSyracuse Mets |
| 22 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 5 - 3 | Syracuse MetsSyracuse Mets |
| 23 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 10 - 4 | Syracuse MetsSyracuse Mets |
| 24 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 10 - 6 | Syracuse MetsSyracuse Mets |
| 24 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 6 - 3 | Syracuse MetsSyracuse Mets |
| 25 Jul 21 | r00 | Buffalo BisonsBuffalo Bison | 3 - 2 | Syracuse MetsSyracuse Mets |
| 28 Jul 21 | r00 | Worcester Red SoxWorcester Red | 1 - 5 | Buffalo BisonsBuffalo Bison |
| 29 Jul 21 | r00 | Worcester Red SoxWorcester Red | 7 - 0 | Buffalo BisonsBuffalo Bison |
| 29 Jul 21 | r00 | Worcester Red SoxWorcester Red | 1 - 8 | Buffalo BisonsBuffalo Bison |
| 30 Jul 21 | r00 | Worcester Red SoxWorcester Red | 6 - 2 | Buffalo BisonsBuffalo Bison |
| 31 Jul 21 | r00 | Worcester Red SoxWorcester Red | 4 - 2 | Buffalo BisonsBuffalo Bison |
| 01 Aug 21 | r00 | Worcester Red SoxWorcester Red | 8 - 1 | Buffalo BisonsBuffalo Bison |
| 04 Aug 21 | r00 | Lehigh Valley IronPigsLehigh Valley | 6 - 1 | Buffalo BisonsBuffalo Bison |
| 05 Aug 21 | r00 | Lehigh Valley IronPigsLehigh Valley | 7 - 1 | Buffalo BisonsBuffalo Bison |
| 06 Aug 21 | r00 | Lehigh Valley IronPigsLehigh Valley | 7 - 9 | Buffalo BisonsBuffalo Bison |
| 07 Aug 21 | r00 | Lehigh Valley IronPigsLehigh Valley | 10 - 9 | Buffalo BisonsBuffalo Bison |
| 07 Aug 21 | r00 | Lehigh Valley IronPigsLehigh Valley | 3 - 9 | Buffalo BisonsBuffalo Bison |
| 08 Aug 21 | r00 | Lehigh Valley IronPigsLehigh Valley | 3 - 9 | Buffalo BisonsBuffalo Bison |
| 11 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 11 - 0 | Rochester Red WingsRochester Red |
| 12 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 5 - 0 | Rochester Red WingsRochester Red |
| 13 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 4 - 3 | Rochester Red WingsRochester Red |
| 14 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 6 - 3 | Rochester Red WingsRochester Red |
| 14 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 0 - 4 | Rochester Red WingsRochester Red |
| 15 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 7 - 1 | Rochester Red WingsRochester Red |
| 18 Aug 21 | r00 | Syracuse MetsSyracuse Mets | P - P | Buffalo BisonsBuffalo Bison |
| 19 Aug 21 | r00 | Syracuse MetsSyracuse Mets | 4 - 3 | Buffalo BisonsBuffalo Bison |
| 19 Aug 21 | r00 | Syracuse MetsSyracuse Mets | 2 - 1 | Buffalo BisonsBuffalo Bison |
| 20 Aug 21 | r00 | Syracuse MetsSyracuse Mets | 1 - 3 | Buffalo BisonsBuffalo Bison |
| 21 Aug 21 | r00 | Syracuse MetsSyracuse Mets | 3 - 0 | Buffalo BisonsBuffalo Bison |
| 22 Aug 21 | r00 | Syracuse MetsSyracuse Mets | 2 - 9 | Buffalo BisonsBuffalo Bison |
| 25 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 2 - 4 | Worcester Red SoxWorcester Red |
| 26 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 4 - 9 | Worcester Red SoxWorcester Red |
| 27 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 5 - 8 | Worcester Red SoxWorcester Red |
| 28 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 1 - 4 | Worcester Red SoxWorcester Red |
| 28 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 6 - 7 | Worcester Red SoxWorcester Red |
| 29 Aug 21 | r00 | Buffalo BisonsBuffalo Bison | 9 - 5 | Worcester Red SoxWorcester Red |
| 31 Aug 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | 1 - 5 | Buffalo BisonsBuffalo Bison |
| 02 Sep 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | - | Buffalo BisonsBuffalo Bison |
| 02 Sep 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | P - P | Buffalo BisonsBuffalo Bison |
| 03 Sep 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | 3 - 5 | Buffalo BisonsBuffalo Bison |
| 04 Sep 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | 0 - 1 | Buffalo BisonsBuffalo Bison |
| 04 Sep 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | 4 - 8 | Buffalo BisonsBuffalo Bison |
| 05 Sep 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | 2 - 6 | Buffalo BisonsBuffalo Bison |
| 05 Sep 21 | r00 | Scranton-Wilkes-Barre RaiScranton-Wilk | 6 - 9 | Buffalo BisonsBuffalo Bison |
| 07 Sep 21 | r00 | Buffalo BisonsBuffalo Bison | 3 - 0 | Syracuse MetsSyracuse Mets |
| 08 Sep 21 | r00 | Buffalo BisonsBuffalo Bison | 8 - 4 | Syracuse MetsSyracuse Mets |
| 09 Sep 21 | r00 | Buffalo BisonsBuffalo Bison | - | Syracuse MetsSyracuse Mets |
| 10 Sep 21 | r00 | Buffalo BisonsBuffalo Bison | 8 - 5 | Syracuse MetsSyracuse Mets |
| 11 Sep 21 | r00 | Buffalo BisonsBuffalo Bison | 2 - 3 | Syracuse MetsSyracuse Mets |
| 12 Sep 21 | r00 | Buffalo BisonsBuffalo Bison | 2 - 10 | Syracuse MetsSyracuse Mets |
| 14 Sep 21 | r00 | Rochester Red WingsRochester Red | 4 - 5 | Buffalo BisonsBuffalo Bison |
| 15 Sep 21 | r00 | Rochester Red WingsRochester Red | 3 - 20 | Buffalo BisonsBuffalo Bison |
| 15 Sep 21 | r00 | Rochester Red WingsRochester Red | P - P | Buffalo BisonsBuffalo Bison |
| 16 Sep 21 | r00 | Rochester Red WingsRochester Red | 5 - 3 | Buffalo BisonsBuffalo Bison |
| 17 Sep 21 | r00 | Rochester Red WingsRochester Red | 7 - 3 | Buffalo BisonsBuffalo Bison |
| 18 Sep 21 | r00 | Rochester Red WingsRochester Red | 4 - 2 | Buffalo BisonsBuffalo Bison |
| 19 Sep 21 | r00 | Rochester Red WingsRochester Red | 1 - 5 | Buffalo BisonsBuffalo Bison |
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