| 31 Oct 21 | r01        | Bechem UnitedBechem United | 4 - 0 | MedeamaMedeama |
| |
| 09 Nov 21 | r02        | MedeamaMedeama | 1 - 1 | Bibiani Gold StarsBibiani Gold |
| |
| 14 Nov 21 | r03        | Eleven WondersEleven Wonder | 0 - 0 | MedeamaMedeama |
| |
| 22 Nov 21 | r04        | MedeamaMedeama | 2 - 0 | Karela UnitedKarela United |
| |
| 28 Nov 21 | r05        | King FaisalKing Faisal | 0 - 0 | MedeamaMedeama |
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| 12 Dec 21 | r07        | Real TamaleReal Tamale | 0 - 1 | MedeamaMedeama |
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| 15 Dec 21 | r08        | MedeamaMedeama | 1 - 0 | Legon CitiesLegon Cities |
| |
| 19 Dec 21 | r09        | WAFAWAFA | 1 - 0 | MedeamaMedeama |
| |
| 26 Dec 21 | r10        | MedeamaMedeama | 1 - 0 | Aduana StarsAduana Stars |
| |
| 03 Jan 22 | r11        | Ashanti GoldAshanti Gold | 0 - 1 | MedeamaMedeama |
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| 07 Jan 22 | r12        | MedeamaMedeama | 1 - 1 | Berekum ChelseaBerekum Chels |
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| 12 Jan 22 | r06        | MedeamaMedeama | 1 - 0 | Hearts of OakHearts of Oak |
| |
| 16 Jan 22 | r13        | MedeamaMedeama | 0 - 0 | Great OlympicsGreat Olympic |
| |
| 23 Jan 22 | r14        | Asante KotokoAsante Kotoko | 1 - 0 | MedeamaMedeama |
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| 30 Jan 22 | r15        | MedeamaMedeama | 1 - 0 | Elmina SharksElmina Sharks |
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| 05 Feb 22 | r16        | Accra LionsAccra Lions | 1 - 0 | MedeamaMedeama |
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| 14 Feb 22 | r17        | MedeamaMedeama | 0 - 1 | Dreams FCDreams FC |
| |
| 27 Feb 22 | r18        | MedeamaMedeama | 1 - 0 | Bechem UnitedBechem United |
| |
| 06 Mar 22 | r19        | Bibiani Gold StarsBibiani Gold | 1 - 0 | MedeamaMedeama |
| |
| 13 Mar 22 | r20        | MedeamaMedeama | 1 - 0 | Eleven WondersEleven Wonder |
| |
| 18 Mar 22 | r21        | Karela UnitedKarela United | 1 - 1 | MedeamaMedeama |
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| 31 Mar 22 | r22        | MedeamaMedeama | 1 - 0 | King FaisalKing Faisal |
| |
| 02 Apr 22 | r23        | Hearts of OakHearts of Oak | 1 - 0 | MedeamaMedeama |
| |
| 10 Apr 22 | r24        | MedeamaMedeama | 2 - 1 | Real TamaleReal Tamale |
| |
| 17 Apr 22 | r25        | Legon CitiesLegon Cities | 3 - 1 | MedeamaMedeama |
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| 24 Apr 22 | r26        | MedeamaMedeama | 1 - 0 | WAFAWAFA |
| |
| 02 May 22 | r27        | Aduana StarsAduana Stars | 1 - 1 | MedeamaMedeama |
| |
| 08 May 22 | r28        | MedeamaMedeama | 2 - 0 | Ashanti GoldAshanti Gold |
| |
| 18 May 22 | r29        | Berekum ChelseaBerekum Chels | 0 - 0 | MedeamaMedeama |
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| 21 May 22 | r30        | Great OlympicsGreat Olympic | 1 - 2 | MedeamaMedeama |
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| 29 May 22 | r31        | MedeamaMedeama | 0 - 2 | Asante KotokoAsante Kotoko |
| |
| 05 Jun 22 | r32        | Elmina SharksElmina Sharks | 1 - 3 | MedeamaMedeama |
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| 12 Jun 22 | r33        | MedeamaMedeama | 2 - 1 | Accra LionsAccra Lions |
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| 19 Jun 22 | r34        | Dreams FCDreams FC | 2 - 0 | MedeamaMedeama |