| 29 Oct 21 | r01        | Accra LionsAccra Lions | 1 - 1 | Elmina SharksElmina Sharks |
| 30 Oct 21 | r01        | Dreams FCDreams FC | 1 - 3 | Asante KotokoAsante Kotoko |
| 31 Oct 21 | r01        | Hearts of OakHearts of Oak | 0 - 0 | Legon CitiesLegon Cities |
| 31 Oct 21 | r01        | King FaisalKing Faisal | 1 - 0 | WAFAWAFA |
| 31 Oct 21 | r01        | Eleven WondersEleven Wonder | 0 - 1 | Ashanti GoldAshanti Gold |
| 31 Oct 21 | r01        | Bechem UnitedBechem United | 4 - 0 | MedeamaMedeama |
| 31 Oct 21 | r01        | Karela UnitedKarela United | 1 - 1 | Aduana StarsAduana Stars |
| 31 Oct 21 | r01        | Bibiani Gold StarsBibiani Gold | 1 - 0 | Berekum ChelseaBerekum Chels |
| 31 Oct 21 | r01        | Real TamaleReal Tamale | 1 - 1 | Great OlympicsGreat Olympic |
| |
| 05 Nov 21 | r02        | WAFAWAFA | 1 - 1 | Hearts of OakHearts of Oak |
| 06 Nov 21 | r02        | Ashanti GoldAshanti Gold | 1 - 1 | Karela UnitedKarela United |
| 06 Nov 21 | r02        | Legon CitiesLegon Cities | 3 - 2 | Real TamaleReal Tamale |
| 07 Nov 21 | r02        | Aduana StarsAduana Stars | 1 - 3 | King FaisalKing Faisal |
| 07 Nov 21 | r02        | Berekum ChelseaBerekum Chels | 0 - 0 | Eleven WondersEleven Wonder |
| 07 Nov 21 | r02        | Asante KotokoAsante Kotoko | 2 - 0 | Bechem UnitedBechem United |
| 07 Nov 21 | r02        | Elmina SharksElmina Sharks | 1 - 3 | Dreams FCDreams FC |
| 07 Nov 21 | r02        | Great OlympicsGreat Olympic | 3 - 1 | Accra LionsAccra Lions |
| 09 Nov 21 | r02        | MedeamaMedeama | 1 - 1 | Bibiani Gold StarsBibiani Gold |
| |
| 12 Nov 21 | r03        | Bibiani Gold StarsBibiani Gold | 0 - 1 | Asante KotokoAsante Kotoko |
| 13 Nov 21 | r03        | Dreams FCDreams FC | 3 - 1 | Accra LionsAccra Lions |
| 13 Nov 21 | r03        | Legon CitiesLegon Cities | 0 - 1 | Great OlympicsGreat Olympic |
| 14 Nov 21 | r03        | Hearts of OakHearts of Oak | 1 - 1 | Aduana StarsAduana Stars |
| 14 Nov 21 | r03        | Eleven WondersEleven Wonder | 0 - 0 | MedeamaMedeama |
| 14 Nov 21 | r03        | Bechem UnitedBechem United | 2 - 0 | Elmina SharksElmina Sharks |
| 14 Nov 21 | r03        | King FaisalKing Faisal | 2 - 0 | Ashanti GoldAshanti Gold |
| 14 Nov 21 | r03        | Karela UnitedKarela United | 2 - 1 | Berekum ChelseaBerekum Chels |
| 14 Nov 21 | r03        | Real TamaleReal Tamale | 2 - 0 | WAFAWAFA |
| |
| 19 Nov 21 | r04        | Berekum ChelseaBerekum Chels | 1 - 0 | King FaisalKing Faisal |
| 20 Nov 21 | r04        | Accra LionsAccra Lions | 2 - 1 | Bechem UnitedBechem United |
| 20 Nov 21 | r04        | Asante KotokoAsante Kotoko | 2 - 0 | Eleven WondersEleven Wonder |
| 21 Nov 21 | r04        | Aduana StarsAduana Stars | 5 - 1 | Real TamaleReal Tamale |
| 21 Nov 21 | r04        | WAFAWAFA | 2 - 2 | Legon CitiesLegon Cities |
| 21 Nov 21 | r04        | Great OlympicsGreat Olympic | 3 - 3 | Dreams FCDreams FC |
| 21 Nov 21 | r04        | Ashanti GoldAshanti Gold | 2 - 0 | Hearts of OakHearts of Oak |
| 21 Nov 21 | r04        | Elmina SharksElmina Sharks | 2 - 1 | Bibiani Gold StarsBibiani Gold |
| 22 Nov 21 | r04        | MedeamaMedeama | 2 - 0 | Karela UnitedKarela United |
| |
| 26 Nov 21 | r05        | Legon CitiesLegon Cities | 0 - 1 | Aduana StarsAduana Stars |
| 27 Nov 21 | r05        | WAFAWAFA | 1 - 0 | Great OlympicsGreat Olympic |
| 28 Nov 21 | r05        | Eleven WondersEleven Wonder | 3 - 1 | Elmina SharksElmina Sharks |
| 28 Nov 21 | r05        | Bechem UnitedBechem United | 3 - 1 | Dreams FCDreams FC |
| 28 Nov 21 | r05        | King FaisalKing Faisal | 0 - 0 | MedeamaMedeama |
| 28 Nov 21 | r05        | Karela UnitedKarela United | 0 - 0 | Asante KotokoAsante Kotoko |
| 28 Nov 21 | r05        | Real TamaleReal Tamale | 2 - 0 | Ashanti GoldAshanti Gold |
| 28 Nov 21 | r05        | Bibiani Gold StarsBibiani Gold | 2 - 0 | Accra LionsAccra Lions |
| |
| 04 Dec 21 | r06        | Aduana StarsAduana Stars | 3 - 0 | WAFAWAFA |
| 04 Dec 21 | r06        | Accra LionsAccra Lions | 1 - 0 | Eleven WondersEleven Wonder |
| 04 Dec 21 | r06        | Elmina SharksElmina Sharks | 2 - 1 | Karela UnitedKarela United |
| 05 Dec 21 | r06        | Great OlympicsGreat Olympic | 0 - 0 | Bechem UnitedBechem United |
| 05 Dec 21 | r06        | Ashanti GoldAshanti Gold | 0 - 0 | Legon CitiesLegon Cities |
| 05 Dec 21 | r06        | Asante KotokoAsante Kotoko | 2 - 3 | King FaisalKing Faisal |
| 05 Dec 21 | r06        | Dreams FCDreams FC | 2 - 1 | Bibiani Gold StarsBibiani Gold |
| 05 Dec 21 | r06        | Berekum ChelseaBerekum Chels | 0 - 1 | Real TamaleReal Tamale |
| |
| 10 Dec 21 | r07        | Eleven WondersEleven Wonder | 1 - 1 | Dreams FCDreams FC |
| 11 Dec 21 | r07        | Aduana StarsAduana Stars | 1 - 0 | Great OlympicsGreat Olympic |
| 12 Dec 21 | r07        | Legon CitiesLegon Cities | 0 - 0 | Berekum ChelseaBerekum Chels |
| 12 Dec 21 | r07        | King FaisalKing Faisal | 1 - 0 | Elmina SharksElmina Sharks |
| 12 Dec 21 | r07        | WAFAWAFA | 0 - 1 | Ashanti GoldAshanti Gold |
| 12 Dec 21 | r07        | Real TamaleReal Tamale | 0 - 1 | MedeamaMedeama |
| 12 Dec 21 | r07        | Bibiani Gold StarsBibiani Gold | 1 - 0 | Bechem UnitedBechem United |
| 12 Dec 21 | r07        | Karela UnitedKarela United | 3 - 0 | Accra LionsAccra Lions |
| |
| 15 Dec 21 | r08        | Great OlympicsGreat Olympic | 2 - 0 | Bibiani Gold StarsBibiani Gold |
| 15 Dec 21 | r08        | Dreams FCDreams FC | 3 - 1 | Karela UnitedKarela United |
| 15 Dec 21 | r08        | Bechem UnitedBechem United | 1 - 0 | Eleven WondersEleven Wonder |
| 15 Dec 21 | r08        | Berekum ChelseaBerekum Chels | 2 - 0 | WAFAWAFA |
| 15 Dec 21 | r08        | MedeamaMedeama | 1 - 0 | Legon CitiesLegon Cities |
| 15 Dec 21 | r08        | Ashanti GoldAshanti Gold | 0 - 1 | Aduana StarsAduana Stars |
| 15 Dec 21 | r08        | Elmina SharksElmina Sharks | 0 - 1 | Hearts of OakHearts of Oak |
| 15 Dec 21 | r08        | Accra LionsAccra Lions | 0 - 0 | King FaisalKing Faisal |
| 15 Dec 21 | r08        | Asante KotokoAsante Kotoko | 1 - 1 | Real TamaleReal Tamale |
| |
| 19 Dec 21 | r09        | Aduana StarsAduana Stars | 3 - 2 | Berekum ChelseaBerekum Chels |
| 19 Dec 21 | r09        | Legon CitiesLegon Cities | 1 - 2 | Asante KotokoAsante Kotoko |
| 19 Dec 21 | r09        | WAFAWAFA | 1 - 0 | MedeamaMedeama |
| 19 Dec 21 | r09        | Ashanti GoldAshanti Gold | 0 - 0 | Great OlympicsGreat Olympic |
| 19 Dec 21 | r09        | Karela UnitedKarela United | 1 - 1 | Bechem UnitedBechem United |
| 19 Dec 21 | r09        | Eleven WondersEleven Wonder | 2 - 1 | Bibiani Gold StarsBibiani Gold |
| 19 Dec 21 | r09        | Real TamaleReal Tamale | 2 - 0 | Elmina SharksElmina Sharks |
| 19 Dec 21 | r09        | Hearts of OakHearts of Oak | 2 - 0 | Accra LionsAccra Lions |
| 21 Dec 21 | r09        | King FaisalKing Faisal | 3 - 2 | Dreams FCDreams FC |
| |
| 25 Dec 21 | r10        | Dreams FCDreams FC | 2 - 2 | Hearts of OakHearts of Oak |
| 26 Dec 21 | r10        | Bechem UnitedBechem United | 1 - 0 | King FaisalKing Faisal |
| 26 Dec 21 | r10        | Berekum ChelseaBerekum Chels | 1 - 0 | Ashanti GoldAshanti Gold |
| 26 Dec 21 | r10        | Great OlympicsGreat Olympic | 2 - 0 | Eleven WondersEleven Wonder |
| 26 Dec 21 | r10        | MedeamaMedeama | 1 - 0 | Aduana StarsAduana Stars |
| 26 Dec 21 | r10        | Asante KotokoAsante Kotoko | 1 - 0 | WAFAWAFA |
| 26 Dec 21 | r10        | Bibiani Gold StarsBibiani Gold | 3 - 1 | Karela UnitedKarela United |
| 27 Dec 21 | r10        | Elmina SharksElmina Sharks | 0 - 2 | Legon CitiesLegon Cities |
| 27 Dec 21 | r10        | Accra LionsAccra Lions | 2 - 1 | Real TamaleReal Tamale |
| |
| 29 Dec 21 | r05        | Hearts of OakHearts of Oak | 2 - 0 | Berekum ChelseaBerekum Chels |
| |
| 01 Jan 22 | r11        | Aduana StarsAduana Stars | 0 - 2 | Asante KotokoAsante Kotoko |
| 02 Jan 22 | r11        | Hearts of OakHearts of Oak | 0 - 0 | Bechem UnitedBechem United |
| 02 Jan 22 | r11        | WAFAWAFA | 2 - 0 | Elmina SharksElmina Sharks |
| 02 Jan 22 | r11        | Karela UnitedKarela United | 4 - 2 | Eleven WondersEleven Wonder |
| 02 Jan 22 | r11        | Real TamaleReal Tamale | 2 - 2 | Dreams FCDreams FC |
| 02 Jan 22 | r11        | King FaisalKing Faisal | 2 - 1 | Bibiani Gold StarsBibiani Gold |
| 03 Jan 22 | r11        | Berekum ChelseaBerekum Chels | 0 - 0 | Great OlympicsGreat Olympic |
| 03 Jan 22 | r11        | Ashanti GoldAshanti Gold | 0 - 1 | MedeamaMedeama |
| 03 Jan 22 | r11        | Legon CitiesLegon Cities | 0 - 1 | Accra LionsAccra Lions |
| |
| 07 Jan 22 | r12        | MedeamaMedeama | 1 - 1 | Berekum ChelseaBerekum Chels |
| 08 Jan 22 | r12        | Bibiani Gold StarsBibiani Gold | 0 - 1 | Hearts of OakHearts of Oak |
| 08 Jan 22 | r12        | Accra LionsAccra Lions | 0 - 0 | WAFAWAFA |