| 31 Oct 21 | r01        | Karela UnitedKarela United | 1 - 1 | Aduana StarsAduana Stars |
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| 06 Nov 21 | r02        | Ashanti GoldAshanti Gold | 1 - 1 | Karela UnitedKarela United |
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| 14 Nov 21 | r03        | Karela UnitedKarela United | 2 - 1 | Berekum ChelseaBerekum Chels |
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| 22 Nov 21 | r04        | MedeamaMedeama | 2 - 0 | Karela UnitedKarela United |
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| 28 Nov 21 | r05        | Karela UnitedKarela United | 0 - 0 | Asante KotokoAsante Kotoko |
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| 04 Dec 21 | r06        | Elmina SharksElmina Sharks | 2 - 1 | Karela UnitedKarela United |
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| 12 Dec 21 | r07        | Karela UnitedKarela United | 3 - 0 | Accra LionsAccra Lions |
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| 15 Dec 21 | r08        | Dreams FCDreams FC | 3 - 1 | Karela UnitedKarela United |
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| 19 Dec 21 | r09        | Karela UnitedKarela United | 1 - 1 | Bechem UnitedBechem United |
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| 26 Dec 21 | r10        | Bibiani Gold StarsBibiani Gold | 3 - 1 | Karela UnitedKarela United |
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| 02 Jan 22 | r11        | Karela UnitedKarela United | 4 - 2 | Eleven WondersEleven Wonder |
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| 09 Jan 22 | r12        | Great OlympicsGreat Olympic | 1 - 1 | Karela UnitedKarela United |
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| 14 Jan 22 | r13        | King FaisalKing Faisal | 0 - 2 | Karela UnitedKarela United |
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| 22 Jan 22 | r14        | Karela UnitedKarela United | 1 - 0 | Hearts of OakHearts of Oak |
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| 30 Jan 22 | r15        | Real TamaleReal Tamale | 1 - 1 | Karela UnitedKarela United |
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| 06 Feb 22 | r16        | Karela UnitedKarela United | 1 - 1 | Legon CitiesLegon Cities |
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| 13 Feb 22 | r17        | WAFAWAFA | 0 - 1 | Karela UnitedKarela United |
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| 27 Feb 22 | r18        | Aduana StarsAduana Stars | 2 - 0 | Karela UnitedKarela United |
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| 06 Mar 22 | r19        | Karela UnitedKarela United | 2 - 1 | Ashanti GoldAshanti Gold |
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| 12 Mar 22 | r20        | Berekum ChelseaBerekum Chels | 1 - 0 | Karela UnitedKarela United |
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| 18 Mar 22 | r21        | Karela UnitedKarela United | 1 - 1 | MedeamaMedeama |
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| 31 Mar 22 | r22        | Asante KotokoAsante Kotoko | 1 - 1 | Karela UnitedKarela United |
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| 03 Apr 22 | r23        | Karela UnitedKarela United | 3 - 1 | Elmina SharksElmina Sharks |
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| 09 Apr 22 | r24        | Accra LionsAccra Lions | 1 - 0 | Karela UnitedKarela United |
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| 17 Apr 22 | r25        | Karela UnitedKarela United | 1 - 0 | Dreams FCDreams FC |
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| 25 Apr 22 | r26        | Bechem UnitedBechem United | 1 - 1 | Karela UnitedKarela United |
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| 01 May 22 | r27        | Karela UnitedKarela United | 2 - 0 | Bibiani Gold StarsBibiani Gold |
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| 08 May 22 | r28        | Eleven WondersEleven Wonder | 2 - 1 | Karela UnitedKarela United |
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| 18 May 22 | r29        | Karela UnitedKarela United | 1 - 0 | Great OlympicsGreat Olympic |
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| 22 May 22 | r30        | Karela UnitedKarela United | 1 - 1 | King FaisalKing Faisal |
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| 30 May 22 | r31        | Hearts of OakHearts of Oak | 1 - 1 | Karela UnitedKarela United |
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| 05 Jun 22 | r32        | Karela UnitedKarela United | 5 - 1 | Real TamaleReal Tamale |
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| 12 Jun 22 | r33        | Legon CitiesLegon Cities | 0 - 0 | Karela UnitedKarela United |
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| 19 Jun 22 | r34        | Karela UnitedKarela United | 1 - 0 | WAFAWAFA |