| 31 Oct 21 | r01  | Karela UnitedKarela United | 1 - 1 | Aduana StarsAduana Stars |
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| 06 Nov 21 | r02 | Ashanti GoldAshanti Gold | 1 - 1 | Karela UnitedKarela United |
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| 14 Nov 21 | r03 | Karela UnitedKarela United | 2 - 1 | Berekum ChelseaBerekum Chels |
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| 22 Nov 21 | r04 | MedeamaMedeama | 2 - 0 | Karela UnitedKarela United |
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| 28 Nov 21 | r05 | Karela UnitedKarela United | 0 - 0 | Asante KotokoAsante Kotoko |
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| 04 Dec 21 | r06 | Elmina SharksElmina Sharks | 2 - 1 | Karela UnitedKarela United |
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| 12 Dec 21 | r07 | Karela UnitedKarela United | 3 - 0 | Accra LionsAccra Lions |
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| 15 Dec 21 | r08 | Dreams FCDreams FC | 3 - 1 | Karela UnitedKarela United |
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| 19 Dec 21 | r09 | Karela UnitedKarela United | 1 - 1 | Bechem UnitedBechem United |
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| 26 Dec 21 | r10 | Bibiani Gold StarsBibiani Gold | 3 - 1 | Karela UnitedKarela United |
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| 02 Jan 22 | r11 | Karela UnitedKarela United | 4 - 2 | Eleven WondersEleven Wonder |
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| 09 Jan 22 | r12 | Great OlympicsGreat Olympic | 1 - 1 | Karela UnitedKarela United |
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| 14 Jan 22 | r13 | King FaisalKing Faisal | 0 - 2 | Karela UnitedKarela United |
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| 22 Jan 22 | r14 | Karela UnitedKarela United | 1 - 0 | Hearts of OakHearts of Oak |
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| 30 Jan 22 | r15 | Real TamaleReal Tamale | 1 - 1 | Karela UnitedKarela United |
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| 06 Feb 22 | r16 | Karela UnitedKarela United | 1 - 1 | Legon CitiesLegon Cities |
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| 13 Feb 22 | r17 | WAFAWAFA | 0 - 1 | Karela UnitedKarela United |
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| 27 Feb 22 | r18 | Aduana StarsAduana Stars | 2 - 0 | Karela UnitedKarela United |
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| 06 Mar 22 | r19 | Karela UnitedKarela United | 2 - 1 | Ashanti GoldAshanti Gold |
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| 12 Mar 22 | r20 | Berekum ChelseaBerekum Chels | 1 - 0 | Karela UnitedKarela United |
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| 18 Mar 22 | r21 | Karela UnitedKarela United | 1 - 1 | MedeamaMedeama |
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| 31 Mar 22 | r22 | Asante KotokoAsante Kotoko | 1 - 1 | Karela UnitedKarela United |
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| 03 Apr 22 | r23 | Karela UnitedKarela United | 3 - 1 | Elmina SharksElmina Sharks |
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| 09 Apr 22 | r24 | Accra LionsAccra Lions | 1 - 0 | Karela UnitedKarela United |
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| 17 Apr 22 | r25 | Karela UnitedKarela United | 1 - 0 | Dreams FCDreams FC |
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| 25 Apr 22 | r26  | Bechem UnitedBechem United | 1 - 1 | Karela UnitedKarela United |
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| 01 May 22 | r27 | Karela UnitedKarela United | 2 - 0 | Bibiani Gold StarsBibiani Gold |
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| 08 May 22 | r28 | Eleven WondersEleven Wonder | 2 - 1 | Karela UnitedKarela United |
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| 18 May 22 | r29 | Karela UnitedKarela United | 1 - 0 | Great OlympicsGreat Olympic |
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| 22 May 22 | r30 | Karela UnitedKarela United | 1 - 1 | King FaisalKing Faisal |
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| 30 May 22 | r31 | Hearts of OakHearts of Oak | 1 - 1 | Karela UnitedKarela United |
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| 05 Jun 22 | r32 | Karela UnitedKarela United | 5 - 1 | Real TamaleReal Tamale |
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| 12 Jun 22 | r33 | Legon CitiesLegon Cities | 0 - 0 | Karela UnitedKarela United |
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| 19 Jun 22 | r34 | Karela UnitedKarela United | 1 - 0 | WAFAWAFA |
Team 2021-2022 Schedules
Aduana Stars
Asante Kotoko
Basake Holy Stars
Bechem United
Berekum Chelsea
Bibiani Gold Stars
Dreams FC
Eleven Wonders
Heart of Lions
Hearts of Oak
Hohoe United
Karela United
Medeama
Nations FC
Samartex
Swedru All Blacks
Vision
Young Apostles
League Table
List
Poster
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= Event Thumb 
= Banner Image 
= Fanart Image 
= Timeline Details