| 31 Oct 21 | r01  | Hearts of OakHearts of Oak | 0 - 0 | Legon CitiesLegon Cities |
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| 05 Nov 21 | r02 | WAFAWAFA | 1 - 1 | Hearts of OakHearts of Oak |
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| 14 Nov 21 | r03 | Hearts of OakHearts of Oak | 1 - 1 | Aduana StarsAduana Stars |
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| 21 Nov 21 | r04 | Ashanti GoldAshanti Gold | 2 - 0 | Hearts of OakHearts of Oak |
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| 15 Dec 21 | r08 | Elmina SharksElmina Sharks | 0 - 1 | Hearts of OakHearts of Oak |
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| 19 Dec 21 | r09 | Hearts of OakHearts of Oak | 2 - 0 | Accra LionsAccra Lions |
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| 25 Dec 21 | r10 | Dreams FCDreams FC | 2 - 2 | Hearts of OakHearts of Oak |
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| 29 Dec 21 | r05 | Hearts of OakHearts of Oak | 2 - 0 | Berekum ChelseaBerekum Chels |
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| 02 Jan 22 | r11 | Hearts of OakHearts of Oak | 0 - 0 | Bechem UnitedBechem United |
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| 08 Jan 22 | r12 | Bibiani Gold StarsBibiani Gold | 0 - 1 | Hearts of OakHearts of Oak |
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| 12 Jan 22 | r06 | MedeamaMedeama | 1 - 0 | Hearts of OakHearts of Oak |
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| 16 Jan 22 | r13 | Hearts of OakHearts of Oak | 4 - 1 | Eleven WondersEleven Wonder |
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| 22 Jan 22 | r14 | Karela UnitedKarela United | 1 - 0 | Hearts of OakHearts of Oak |
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| 30 Jan 22 | r15 | Hearts of OakHearts of Oak | 1 - 0 | King FaisalKing Faisal |
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| 06 Feb 22 | r16 | Hearts of OakHearts of Oak | 0 - 1 | Great OlympicsGreat Olympic |
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| 13 Feb 22 | r17 | Real TamaleReal Tamale | 0 - 0 | Hearts of OakHearts of Oak |
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| 20 Feb 22 | r07 | Hearts of OakHearts of Oak | 0 - 0 | Asante KotokoAsante Kotoko |
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| 26 Feb 22 | r18 | Legon CitiesLegon Cities | 1 - 1 | Hearts of OakHearts of Oak |
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| 09 Mar 22 | r19 | Hearts of OakHearts of Oak | 2 - 1 | WAFAWAFA |
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| 13 Mar 22 | r20 | Aduana StarsAduana Stars | 1 - 0 | Hearts of OakHearts of Oak |
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| 20 Mar 22 | r21 | Hearts of OakHearts of Oak | 2 - 1 | Ashanti GoldAshanti Gold |
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| 30 Mar 22 | r22 | Berekum ChelseaBerekum Chels | 0 - 0 | Hearts of OakHearts of Oak |
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| 02 Apr 22 | r23 | Hearts of OakHearts of Oak | 1 - 0 | MedeamaMedeama |
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| 10 Apr 22 | r24 | Asante KotokoAsante Kotoko | 1 - 0 | Hearts of OakHearts of Oak |
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| 17 Apr 22 | r25 | Hearts of OakHearts of Oak | 1 - 1 | Elmina SharksElmina Sharks |
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| 22 Apr 22 | r26 | Accra LionsAccra Lions | 0 - 3 | Hearts of OakHearts of Oak |
| 22 Apr 22 | r26 | Accra LionsAccra Lions | 0 - 3 | Hearts of OakHearts of Oak |
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| 01 May 22 | r27 | Hearts of OakHearts of Oak | 3 - 1 | Dreams FCDreams FC |
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| 07 May 22 | r28 | Bechem UnitedBechem United | 1 - 1 | Hearts of OakHearts of Oak |
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| 18 May 22 | r29 | Hearts of OakHearts of Oak | 1 - 0 | Bibiani Gold StarsBibiani Gold |
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| 30 May 22 | r31 | Hearts of OakHearts of Oak | 1 - 1 | Karela UnitedKarela United |
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| 05 Jun 22 | r32 | King FaisalKing Faisal | 1 - 0 | Hearts of OakHearts of Oak |
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| 08 Jun 22 | r30 | Eleven WondersEleven Wonder | 2 - 1 | Hearts of OakHearts of Oak |
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| 12 Jun 22 | r33 | Great OlympicsGreat Olympic | 3 - 0 | Hearts of OakHearts of Oak |
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| 19 Jun 22 | r34 | Hearts of OakHearts of Oak | 1 - 4 | Real TamaleReal Tamale |
Team 2021-2022 Schedules
Aduana Stars
Asante Kotoko
Basake Holy Stars
Bechem United
Berekum Chelsea
Bibiani Gold Stars
Dreams FC
Eleven Wonders
Heart of Lions
Hearts of Oak
Hohoe United
Karela United
Medeama
Nations FC
Samartex
Swedru All Blacks
Vision
Young Apostles
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