| 31 Oct 21 | r01  | Karela UnitedKarela United | 1 - 1 | Aduana StarsAduana Stars |
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| 07 Nov 21 | r02 | Aduana StarsAduana Stars | 1 - 3 | King FaisalKing Faisal |
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| 14 Nov 21 | r03 | Hearts of OakHearts of Oak | 1 - 1 | Aduana StarsAduana Stars |
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| 21 Nov 21 | r04 | Aduana StarsAduana Stars | 5 - 1 | Real TamaleReal Tamale |
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| 26 Nov 21 | r05 | Legon CitiesLegon Cities | 0 - 1 | Aduana StarsAduana Stars |
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| 04 Dec 21 | r06 | Aduana StarsAduana Stars | 3 - 0 | WAFAWAFA |
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| 11 Dec 21 | r07 | Aduana StarsAduana Stars | 1 - 0 | Great OlympicsGreat Olympic |
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| 15 Dec 21 | r08 | Ashanti GoldAshanti Gold | 0 - 1 | Aduana StarsAduana Stars |
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| 19 Dec 21 | r09 | Aduana StarsAduana Stars | 3 - 2 | Berekum ChelseaBerekum Chels |
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| 26 Dec 21 | r10 | MedeamaMedeama | 1 - 0 | Aduana StarsAduana Stars |
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| 01 Jan 22 | r11 | Aduana StarsAduana Stars | 0 - 2 | Asante KotokoAsante Kotoko |
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| 09 Jan 22 | r12 | Elmina SharksElmina Sharks | 0 - 1 | Aduana StarsAduana Stars |
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| 16 Jan 22 | r13 | Aduana StarsAduana Stars | 1 - 1 | Accra LionsAccra Lions |
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| 24 Jan 22 | r14 | Dreams FCDreams FC | 3 - 1 | Aduana StarsAduana Stars |
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| 29 Jan 22 | r15 | Aduana StarsAduana Stars | 0 - 1 | Bechem UnitedBechem United |
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| 06 Feb 22 | r16 | Bibiani Gold StarsBibiani Gold | 1 - 0 | Aduana StarsAduana Stars |
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| 13 Feb 22 | r17 | Aduana StarsAduana Stars | 3 - 0 | Eleven WondersEleven Wonder |
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| 27 Feb 22 | r18 | Aduana StarsAduana Stars | 2 - 0 | Karela UnitedKarela United |
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| 06 Mar 22 | r19 | King FaisalKing Faisal | 0 - 1 | Aduana StarsAduana Stars |
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| 13 Mar 22 | r20 | Aduana StarsAduana Stars | 1 - 0 | Hearts of OakHearts of Oak |
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| 20 Mar 22 | r21 | Real TamaleReal Tamale | 1 - 1 | Aduana StarsAduana Stars |
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| 30 Mar 22 | r22 | Aduana StarsAduana Stars | 1 - 1 | Legon CitiesLegon Cities |
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| 03 Apr 22 | r23 | WAFAWAFA | 0 - 0 | Aduana StarsAduana Stars |
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| 10 Apr 22 | r24 | Great OlympicsGreat Olympic | 2 - 1 | Aduana StarsAduana Stars |
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| 17 Apr 22 | r25 | Aduana StarsAduana Stars | 0 - 0 | Ashanti GoldAshanti Gold |
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| 24 Apr 22 | r26 | Berekum ChelseaBerekum Chels | 1 - 0 | Aduana StarsAduana Stars |
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| 02 May 22 | r27 | Aduana StarsAduana Stars | 1 - 1 | MedeamaMedeama |
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| 08 May 22 | r28 | Asante KotokoAsante Kotoko | 1 - 1 | Aduana StarsAduana Stars |
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| 18 May 22 | r29 | Aduana StarsAduana Stars | 0 - 0 | Elmina SharksElmina Sharks |
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| 22 May 22 | r30 | Accra LionsAccra Lions | 0 - 0 | Aduana StarsAduana Stars |
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| 29 May 22 | r31 | Aduana StarsAduana Stars | 0 - 0 | Dreams FCDreams FC |
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| 05 Jun 22 | r32 | Bechem UnitedBechem United | 1 - 0 | Aduana StarsAduana Stars |
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| 12 Jun 22 | r33 | Aduana StarsAduana Stars | 0 - 1 | Bibiani Gold StarsBibiani Gold |
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| 19 Jun 22 | r34 | Eleven WondersEleven Wonder | 2 - 1 | Aduana StarsAduana Stars |
Team 2021-2022 Schedules
Aduana Stars
Asante Kotoko
Basake Holy Stars
Bechem United
Berekum Chelsea
Bibiani Gold Stars
Dreams FC
Eleven Wonders
Heart of Lions
Hearts of Oak
Hohoe United
Karela United
Medeama
Nations FC
Samartex
Swedru All Blacks
Vision
Young Apostles
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