| 31 Oct 21 | r01        | Karela UnitedKarela United | 1 - 1 | Aduana StarsAduana Stars |
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| 07 Nov 21 | r02        | Aduana StarsAduana Stars | 1 - 3 | King FaisalKing Faisal |
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| 14 Nov 21 | r03        | Hearts of OakHearts of Oak | 1 - 1 | Aduana StarsAduana Stars |
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| 21 Nov 21 | r04        | Aduana StarsAduana Stars | 5 - 1 | Real TamaleReal Tamale |
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| 26 Nov 21 | r05        | Legon CitiesLegon Cities | 0 - 1 | Aduana StarsAduana Stars |
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| 04 Dec 21 | r06        | Aduana StarsAduana Stars | 3 - 0 | WAFAWAFA |
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| 11 Dec 21 | r07        | Aduana StarsAduana Stars | 1 - 0 | Great OlympicsGreat Olympic |
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| 15 Dec 21 | r08        | Ashanti GoldAshanti Gold | 0 - 1 | Aduana StarsAduana Stars |
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| 19 Dec 21 | r09        | Aduana StarsAduana Stars | 3 - 2 | Berekum ChelseaBerekum Chels |
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| 26 Dec 21 | r10        | MedeamaMedeama | 1 - 0 | Aduana StarsAduana Stars |
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| 01 Jan 22 | r11        | Aduana StarsAduana Stars | 0 - 2 | Asante KotokoAsante Kotoko |
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| 09 Jan 22 | r12        | Elmina SharksElmina Sharks | 0 - 1 | Aduana StarsAduana Stars |
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| 16 Jan 22 | r13        | Aduana StarsAduana Stars | 1 - 1 | Accra LionsAccra Lions |
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| 24 Jan 22 | r14        | Dreams FCDreams FC | 3 - 1 | Aduana StarsAduana Stars |
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| 29 Jan 22 | r15        | Aduana StarsAduana Stars | 0 - 1 | Bechem UnitedBechem United |
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| 06 Feb 22 | r16        | Bibiani Gold StarsBibiani Gold | 1 - 0 | Aduana StarsAduana Stars |
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| 13 Feb 22 | r17        | Aduana StarsAduana Stars | 3 - 0 | Eleven WondersEleven Wonder |
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| 27 Feb 22 | r18        | Aduana StarsAduana Stars | 2 - 0 | Karela UnitedKarela United |
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| 06 Mar 22 | r19        | King FaisalKing Faisal | 0 - 1 | Aduana StarsAduana Stars |
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| 13 Mar 22 | r20        | Aduana StarsAduana Stars | 1 - 0 | Hearts of OakHearts of Oak |
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| 20 Mar 22 | r21        | Real TamaleReal Tamale | 1 - 1 | Aduana StarsAduana Stars |
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| 30 Mar 22 | r22        | Aduana StarsAduana Stars | 1 - 1 | Legon CitiesLegon Cities |
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| 03 Apr 22 | r23        | WAFAWAFA | 0 - 0 | Aduana StarsAduana Stars |
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| 10 Apr 22 | r24        | Great OlympicsGreat Olympic | 2 - 1 | Aduana StarsAduana Stars |
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| 17 Apr 22 | r25        | Aduana StarsAduana Stars | 0 - 0 | Ashanti GoldAshanti Gold |
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| 24 Apr 22 | r26        | Berekum ChelseaBerekum Chels | 1 - 0 | Aduana StarsAduana Stars |
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| 02 May 22 | r27        | Aduana StarsAduana Stars | 1 - 1 | MedeamaMedeama |
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| 08 May 22 | r28        | Asante KotokoAsante Kotoko | 1 - 1 | Aduana StarsAduana Stars |
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| 18 May 22 | r29        | Aduana StarsAduana Stars | 0 - 0 | Elmina SharksElmina Sharks |
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| 22 May 22 | r30        | Accra LionsAccra Lions | 0 - 0 | Aduana StarsAduana Stars |
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| 29 May 22 | r31        | Aduana StarsAduana Stars | 0 - 0 | Dreams FCDreams FC |
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| 05 Jun 22 | r32        | Bechem UnitedBechem United | 1 - 0 | Aduana StarsAduana Stars |
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| 12 Jun 22 | r33        | Aduana StarsAduana Stars | 0 - 1 | Bibiani Gold StarsBibiani Gold |
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| 19 Jun 22 | r34        | Eleven WondersEleven Wonder | 2 - 1 | Aduana StarsAduana Stars |