| 29 Oct 21 | r01  | Accra LionsAccra Lions | 1 - 1 | Elmina SharksElmina Sharks |
| 30 Oct 21 | r01 | Dreams FCDreams FC | 1 - 3 | Asante KotokoAsante Kotoko |
| 31 Oct 21 | r01 | Hearts of OakHearts of Oak | 0 - 0 | Legon CitiesLegon Cities |
| 31 Oct 21 | r01 | King FaisalKing Faisal | 1 - 0 | WAFAWAFA |
| 31 Oct 21 | r01 | Eleven WondersEleven Wonder | 0 - 1 | Ashanti GoldAshanti Gold |
| 31 Oct 21 | r01 | Bechem UnitedBechem United | 4 - 0 | MedeamaMedeama |
| 31 Oct 21 | r01 | Karela UnitedKarela United | 1 - 1 | Aduana StarsAduana Stars |
| 31 Oct 21 | r01 | Bibiani Gold StarsBibiani Gold | 1 - 0 | Berekum ChelseaBerekum Chels |
| 31 Oct 21 | r01 | Real TamaleReal Tamale | 1 - 1 | Great OlympicsGreat Olympic |
| |
| 05 Nov 21 | r02 | WAFAWAFA | 1 - 1 | Hearts of OakHearts of Oak |
| 06 Nov 21 | r02 | Ashanti GoldAshanti Gold | 1 - 1 | Karela UnitedKarela United |
| 06 Nov 21 | r02 | Legon CitiesLegon Cities | 3 - 2 | Real TamaleReal Tamale |
| 07 Nov 21 | r02 | Aduana StarsAduana Stars | 1 - 3 | King FaisalKing Faisal |
| 07 Nov 21 | r02 | Berekum ChelseaBerekum Chels | 0 - 0 | Eleven WondersEleven Wonder |
| 07 Nov 21 | r02 | Asante KotokoAsante Kotoko | 2 - 0 | Bechem UnitedBechem United |
| 07 Nov 21 | r02 | Elmina SharksElmina Sharks | 1 - 3 | Dreams FCDreams FC |
| 07 Nov 21 | r02 | Great OlympicsGreat Olympic | 3 - 1 | Accra LionsAccra Lions |
| 09 Nov 21 | r02 | MedeamaMedeama | 1 - 1 | Bibiani Gold StarsBibiani Gold |
| |
| 12 Nov 21 | r03 | Bibiani Gold StarsBibiani Gold | 0 - 1 | Asante KotokoAsante Kotoko |
| 13 Nov 21 | r03 | Dreams FCDreams FC | 3 - 1 | Accra LionsAccra Lions |
| 13 Nov 21 | r03 | Legon CitiesLegon Cities | 0 - 1 | Great OlympicsGreat Olympic |
| 14 Nov 21 | r03 | Hearts of OakHearts of Oak | 1 - 1 | Aduana StarsAduana Stars |
| 14 Nov 21 | r03 | Eleven WondersEleven Wonder | 0 - 0 | MedeamaMedeama |
| 14 Nov 21 | r03 | Bechem UnitedBechem United | 2 - 0 | Elmina SharksElmina Sharks |
| 14 Nov 21 | r03 | King FaisalKing Faisal | 2 - 0 | Ashanti GoldAshanti Gold |
| 14 Nov 21 | r03 | Karela UnitedKarela United | 2 - 1 | Berekum ChelseaBerekum Chels |
| 14 Nov 21 | r03 | Real TamaleReal Tamale | 2 - 0 | WAFAWAFA |
| |
| 19 Nov 21 | r04 | Berekum ChelseaBerekum Chels | 1 - 0 | King FaisalKing Faisal |
| 20 Nov 21 | r04 | Accra LionsAccra Lions | 2 - 1 | Bechem UnitedBechem United |
| 20 Nov 21 | r04 | Asante KotokoAsante Kotoko | 2 - 0 | Eleven WondersEleven Wonder |
| 21 Nov 21 | r04 | Aduana StarsAduana Stars | 5 - 1 | Real TamaleReal Tamale |
| 21 Nov 21 | r04 | WAFAWAFA | 2 - 2 | Legon CitiesLegon Cities |
| 21 Nov 21 | r04 | Great OlympicsGreat Olympic | 3 - 3 | Dreams FCDreams FC |
| 21 Nov 21 | r04 | Ashanti GoldAshanti Gold | 2 - 0 | Hearts of OakHearts of Oak |
| 21 Nov 21 | r04 | Elmina SharksElmina Sharks | 2 - 1 | Bibiani Gold StarsBibiani Gold |
| 22 Nov 21 | r04 | MedeamaMedeama | 2 - 0 | Karela UnitedKarela United |
| |
| 26 Nov 21 | r05 | Legon CitiesLegon Cities | 0 - 1 | Aduana StarsAduana Stars |
| 27 Nov 21 | r05 | WAFAWAFA | 1 - 0 | Great OlympicsGreat Olympic |
| 28 Nov 21 | r05 | Eleven WondersEleven Wonder | 3 - 1 | Elmina SharksElmina Sharks |
| 28 Nov 21 | r05 | Bechem UnitedBechem United | 3 - 1 | Dreams FCDreams FC |
| 28 Nov 21 | r05 | King FaisalKing Faisal | 0 - 0 | MedeamaMedeama |
| 28 Nov 21 | r05 | Karela UnitedKarela United | 0 - 0 | Asante KotokoAsante Kotoko |
| 28 Nov 21 | r05 | Real TamaleReal Tamale | 2 - 0 | Ashanti GoldAshanti Gold |
| 28 Nov 21 | r05 | Bibiani Gold StarsBibiani Gold | 2 - 0 | Accra LionsAccra Lions |
| |
| 04 Dec 21 | r06 | Aduana StarsAduana Stars | 3 - 0 | WAFAWAFA |
| 04 Dec 21 | r06 | Accra LionsAccra Lions | 1 - 0 | Eleven WondersEleven Wonder |
| 04 Dec 21 | r06 | Elmina SharksElmina Sharks | 2 - 1 | Karela UnitedKarela United |
| 05 Dec 21 | r06 | Great OlympicsGreat Olympic | 0 - 0 | Bechem UnitedBechem United |
| 05 Dec 21 | r06 | Ashanti GoldAshanti Gold | 0 - 0 | Legon CitiesLegon Cities |
| 05 Dec 21 | r06 | Asante KotokoAsante Kotoko | 2 - 3 | King FaisalKing Faisal |
| 05 Dec 21 | r06 | Dreams FCDreams FC | 2 - 1 | Bibiani Gold StarsBibiani Gold |
| 05 Dec 21 | r06 | Berekum ChelseaBerekum Chels | 0 - 1 | Real TamaleReal Tamale |
| |
| 10 Dec 21 | r07 | Eleven WondersEleven Wonder | 1 - 1 | Dreams FCDreams FC |
| 11 Dec 21 | r07 | Aduana StarsAduana Stars | 1 - 0 | Great OlympicsGreat Olympic |
| 12 Dec 21 | r07 | Legon CitiesLegon Cities | 0 - 0 | Berekum ChelseaBerekum Chels |
| 12 Dec 21 | r07 | King FaisalKing Faisal | 1 - 0 | Elmina SharksElmina Sharks |
| 12 Dec 21 | r07 | WAFAWAFA | 0 - 1 | Ashanti GoldAshanti Gold |
| 12 Dec 21 | r07 | Real TamaleReal Tamale | 0 - 1 | MedeamaMedeama |
| 12 Dec 21 | r07 | Bibiani Gold StarsBibiani Gold | 1 - 0 | Bechem UnitedBechem United |
| 12 Dec 21 | r07 | Karela UnitedKarela United | 3 - 0 | Accra LionsAccra Lions |
| |
| 15 Dec 21 | r08 | Great OlympicsGreat Olympic | 2 - 0 | Bibiani Gold StarsBibiani Gold |
| 15 Dec 21 | r08 | Dreams FCDreams FC | 3 - 1 | Karela UnitedKarela United |
| 15 Dec 21 | r08 | Bechem UnitedBechem United | 1 - 0 | Eleven WondersEleven Wonder |
| 15 Dec 21 | r08 | Berekum ChelseaBerekum Chels | 2 - 0 | WAFAWAFA |
| 15 Dec 21 | r08 | MedeamaMedeama | 1 - 0 | Legon CitiesLegon Cities |
| 15 Dec 21 | r08 | Ashanti GoldAshanti Gold | 0 - 1 | Aduana StarsAduana Stars |
| 15 Dec 21 | r08 | Elmina SharksElmina Sharks | 0 - 1 | Hearts of OakHearts of Oak |
| 15 Dec 21 | r08 | Accra LionsAccra Lions | 0 - 0 | King FaisalKing Faisal |
| 15 Dec 21 | r08 | Asante KotokoAsante Kotoko | 1 - 1 | Real TamaleReal Tamale |
| |
| 19 Dec 21 | r09 | Aduana StarsAduana Stars | 3 - 2 | Berekum ChelseaBerekum Chels |
| 19 Dec 21 | r09 | Legon CitiesLegon Cities | 1 - 2 | Asante KotokoAsante Kotoko |
| 19 Dec 21 | r09 | WAFAWAFA | 1 - 0 | MedeamaMedeama |
| 19 Dec 21 | r09 | Ashanti GoldAshanti Gold | 0 - 0 | Great OlympicsGreat Olympic |
| 19 Dec 21 | r09 | Karela UnitedKarela United | 1 - 1 | Bechem UnitedBechem United |
| 19 Dec 21 | r09 | Eleven WondersEleven Wonder | 2 - 1 | Bibiani Gold StarsBibiani Gold |
| 19 Dec 21 | r09 | Real TamaleReal Tamale | 2 - 0 | Elmina SharksElmina Sharks |
| 19 Dec 21 | r09 | Hearts of OakHearts of Oak | 2 - 0 | Accra LionsAccra Lions |
| 21 Dec 21 | r09 | King FaisalKing Faisal | 3 - 2 | Dreams FCDreams FC |
| |
| 25 Dec 21 | r10 | Dreams FCDreams FC | 2 - 2 | Hearts of OakHearts of Oak |
| 26 Dec 21 | r10 | Bechem UnitedBechem United | 1 - 0 | King FaisalKing Faisal |
| 26 Dec 21 | r10 | Berekum ChelseaBerekum Chels | 1 - 0 | Ashanti GoldAshanti Gold |
| 26 Dec 21 | r10 | Great OlympicsGreat Olympic | 2 - 0 | Eleven WondersEleven Wonder |
| 26 Dec 21 | r10 | MedeamaMedeama | 1 - 0 | Aduana StarsAduana Stars |
| 26 Dec 21 | r10 | Asante KotokoAsante Kotoko | 1 - 0 | WAFAWAFA |
| 26 Dec 21 | r10 | Bibiani Gold StarsBibiani Gold | 3 - 1 | Karela UnitedKarela United |
| 27 Dec 21 | r10 | Elmina SharksElmina Sharks | 0 - 2 | Legon CitiesLegon Cities |
| 27 Dec 21 | r10 | Accra LionsAccra Lions | 2 - 1 | Real TamaleReal Tamale |
| |
| 29 Dec 21 | r05 | Hearts of OakHearts of Oak | 2 - 0 | Berekum ChelseaBerekum Chels |
| |
| 01 Jan 22 | r11 | Aduana StarsAduana Stars | 0 - 2 | Asante KotokoAsante Kotoko |
| 02 Jan 22 | r11 | Hearts of OakHearts of Oak | 0 - 0 | Bechem UnitedBechem United |
| 02 Jan 22 | r11 | WAFAWAFA | 2 - 0 | Elmina SharksElmina Sharks |
| 02 Jan 22 | r11 | Karela UnitedKarela United | 4 - 2 | Eleven WondersEleven Wonder |
| 02 Jan 22 | r11 | Real TamaleReal Tamale | 2 - 2 | Dreams FCDreams FC |
| 02 Jan 22 | r11 | King FaisalKing Faisal | 2 - 1 | Bibiani Gold StarsBibiani Gold |
| 03 Jan 22 | r11 | Berekum ChelseaBerekum Chels | 0 - 0 | Great OlympicsGreat Olympic |
| 03 Jan 22 | r11 | Ashanti GoldAshanti Gold | 0 - 1 | MedeamaMedeama |
| 03 Jan 22 | r11 | Legon CitiesLegon Cities | 0 - 1 | Accra LionsAccra Lions |
| |
| 07 Jan 22 | r12 | MedeamaMedeama | 1 - 1 | Berekum ChelseaBerekum Chels |
| 08 Jan 22 | r12 | Bibiani Gold StarsBibiani Gold | 0 - 1 | Hearts of OakHearts of Oak |
| 08 Jan 22 | r12 | Accra LionsAccra Lions | 0 - 0 | WAFAWAFA |
| 09 Jan 22 | r12 | Eleven WondersEleven Wonder | 2 - 0 | King FaisalKing Faisal |
| 09 Jan 22 | r12 | Dreams FCDreams FC | 0 - 1 | Legon CitiesLegon Cities |
| 09 Jan 22 | r12 | Great OlympicsGreat Olympic | 1 - 1 | Karela UnitedKarela United |
| 09 Jan 22 | r12 | Elmina SharksElmina Sharks | 0 - 1 | Aduana StarsAduana Stars |
| 09 Jan 22 | r12 | Asante KotokoAsante Kotoko | 3 - 1 | Ashanti GoldAshanti Gold |
| 09 Jan 22 | r12 | Bechem UnitedBechem United | 2 - 0 | Real TamaleReal Tamale |
| |
| 12 Jan 22 | r06 | MedeamaMedeama | 1 - 0 | Hearts of OakHearts of Oak |
| |
| 14 Jan 22 | r13 | King FaisalKing Faisal | 0 - 2 | Karela UnitedKarela United |
| 15 Jan 22 | r13 | Berekum ChelseaBerekum Chels | 0 - 0 | Asante KotokoAsante Kotoko |
| 16 Jan 22 | r13 | Hearts of OakHearts of Oak | 4 - 1 | Eleven WondersEleven Wonder |
| 16 Jan 22 | r13 | WAFAWAFA | 1 - 1 | Dreams FCDreams FC |
| 16 Jan 22 | r13 | MedeamaMedeama | 0 - 0 | Great OlympicsGreat Olympic |
| 16 Jan 22 | r13 | Ashanti GoldAshanti Gold | 4 - 0 | Elmina SharksElmina Sharks |
| 16 Jan 22 | r13 | Aduana StarsAduana Stars | 1 - 1 | Accra LionsAccra Lions |
| 16 Jan 22 | r13 | Real TamaleReal Tamale | 2 - 0 | Bibiani Gold StarsBibiani Gold |
| 17 Jan 22 | r13 | Legon CitiesLegon Cities | 0 - 0 | Bechem UnitedBechem United |
| |
| 22 Jan 22 | r14 | Karela UnitedKarela United | 1 - 0 | Hearts of OakHearts of Oak |
| 22 Jan 22 | r14 | Accra LionsAccra Lions | 0 - 1 | Ashanti GoldAshanti Gold |
| 23 Jan 22 | r14 | Bechem UnitedBechem United | 0 - 0 | WAFAWAFA |
| 23 Jan 22 | r14 | Great OlympicsGreat Olympic | 2 - 1 | King FaisalKing Faisal |
| 23 Jan 22 | r14 | Elmina SharksElmina Sharks | 0 - 0 | Berekum ChelseaBerekum Chels |
| 23 Jan 22 | r14 | Asante KotokoAsante Kotoko | 1 - 0 | MedeamaMedeama |
| 23 Jan 22 | r14 | Eleven WondersEleven Wonder | 1 - 0 | Real TamaleReal Tamale |
| 23 Jan 22 | r14 | Bibiani Gold StarsBibiani Gold | 2 - 1 | Legon CitiesLegon Cities |
| 24 Jan 22 | r14 | Dreams FCDreams FC | 3 - 1 | Aduana StarsAduana Stars |
| |
| 28 Jan 22 | r15 | Asante KotokoAsante Kotoko | 2 - 0 | Great OlympicsGreat Olympic |
| 29 Jan 22 | r15 | Aduana StarsAduana Stars | 0 - 1 | Bechem UnitedBechem United |
| 30 Jan 22 | r15 | Hearts of OakHearts of Oak | 1 - 0 | King FaisalKing Faisal |
| 30 Jan 22 | r15 | Legon CitiesLegon Cities | 3 - 0 | Eleven WondersEleven Wonder |
| 30 Jan 22 | r15 | MedeamaMedeama | 1 - 0 | Elmina SharksElmina Sharks |
| 30 Jan 22 | r15 | Ashanti GoldAshanti Gold | 2 - 1 | Dreams FCDreams FC |
| 30 Jan 22 | r15 | Real TamaleReal Tamale | 1 - 1 | Karela UnitedKarela United |
| 30 Jan 22 | r15 | Berekum ChelseaBerekum Chels | 3 - 1 | Accra LionsAccra Lions |
| 30 Jan 22 | r15 | WAFAWAFA | 1 - 0 | Bibiani Gold StarsBibiani Gold |
| |
| 04 Feb 22 | r16 | Bechem UnitedBechem United | 2 - 0 | Ashanti GoldAshanti Gold |
| 05 Feb 22 | r16 | King FaisalKing Faisal | 2 - 0 | Real TamaleReal Tamale |
| 05 Feb 22 | r16 | Accra LionsAccra Lions | 1 - 0 | MedeamaMedeama |
| 06 Feb 22 | r16 | Eleven WondersEleven Wonder | 0 - 0 | WAFAWAFA |
| 06 Feb 22 | r16 | Dreams FCDreams FC | 0 - 1 | Berekum ChelseaBerekum Chels |
| 06 Feb 22 | r16 | Hearts of OakHearts of Oak | 0 - 1 | Great OlympicsGreat Olympic |
| 06 Feb 22 | r16 | Karela UnitedKarela United | 1 - 1 | Legon CitiesLegon Cities |
| 06 Feb 22 | r16 | Bibiani Gold StarsBibiani Gold | 1 - 0 | Aduana StarsAduana Stars |
| 07 Feb 22 | r16 | Elmina SharksElmina Sharks | 2 - 1 | Asante KotokoAsante Kotoko |
| |
| 11 Feb 22 | r17 | Berekum ChelseaBerekum Chels | 1 - 1 | Bechem UnitedBechem United |
| 12 Feb 22 | r17 | Asante KotokoAsante Kotoko | 3 - 1 | Accra LionsAccra Lions |
| 13 Feb 22 | r17 | Aduana StarsAduana Stars | 3 - 0 | Eleven WondersEleven Wonder |
| 13 Feb 22 | r17 | WAFAWAFA | 0 - 1 | Karela UnitedKarela United |
| 13 Feb 22 | r17 | Great OlympicsGreat Olympic | 1 - 0 | Elmina SharksElmina Sharks |
| 13 Feb 22 | r17 | Real TamaleReal Tamale | 0 - 0 | Hearts of OakHearts of Oak |
| 13 Feb 22 | r17 | Ashanti GoldAshanti Gold | 2 - 2 | Bibiani Gold StarsBibiani Gold |
| 14 Feb 22 | r17 | MedeamaMedeama | 0 - 1 | Dreams FCDreams FC |
| 14 Feb 22 | r17 | Legon CitiesLegon Cities | 1 - 0 | King FaisalKing Faisal |
| |
| 20 Feb 22 | r07 | Hearts of OakHearts of Oak | 0 - 0 | Asante KotokoAsante Kotoko |
| |
| 25 Feb 22 | r18 | WAFAWAFA | 1 - 2 | King FaisalKing Faisal |
| 26 Feb 22 | r18 | Legon CitiesLegon Cities | 1 - 1 | Hearts of OakHearts of Oak |
| 27 Feb 22 | r18 | Aduana StarsAduana Stars | 2 - 0 | Karela UnitedKarela United |
| 27 Feb 22 | r18 | MedeamaMedeama | 1 - 0 | Bechem UnitedBechem United |
| 27 Feb 22 | r18 | Ashanti GoldAshanti Gold | 1 - 4 | Eleven WondersEleven Wonder |
| 27 Feb 22 | r18 | Asante KotokoAsante Kotoko | 2 - 0 | Dreams FCDreams FC |
| 27 Feb 22 | r18 | Berekum ChelseaBerekum Chels | 1 - 0 | Bibiani Gold StarsBibiani Gold |
| 27 Feb 22 | r18 | Elmina SharksElmina Sharks | 1 - 1 | Accra LionsAccra Lions |
| 28 Feb 22 | r18 | Great OlympicsGreat Olympic | 2 - 1 | Real TamaleReal Tamale |
| |
| 05 Mar 22 | r19 | Real TamaleReal Tamale | 1 - 1 | Legon CitiesLegon Cities |
| 06 Mar 22 | r19 | Dreams FCDreams FC | 2 - 0 | Elmina SharksElmina Sharks |
| 06 Mar 22 | r19 | King FaisalKing Faisal | 0 - 1 | Aduana StarsAduana Stars |
| 06 Mar 22 | r19 | Karela UnitedKarela United | 2 - 1 | Ashanti GoldAshanti Gold |
| 06 Mar 22 | r19 | Bibiani Gold StarsBibiani Gold | 1 - 0 | MedeamaMedeama |
| 06 Mar 22 | r19 | Accra LionsAccra Lions | 0 - 0 | Great OlympicsGreat Olympic |
| 07 Mar 22 | r19 | Eleven WondersEleven Wonder | 1 - 1 | Berekum ChelseaBerekum Chels |
| 08 Mar 22 | r19 | Bechem UnitedBechem United | 0 - 0 | Asante KotokoAsante Kotoko |
| 09 Mar 22 | r19 | Hearts of OakHearts of Oak | 2 - 1 | WAFAWAFA |
| |
| 11 Mar 22 | r20 | Ashanti GoldAshanti Gold | 2 - 0 | King FaisalKing Faisal |
| 12 Mar 22 | r20 | Berekum ChelseaBerekum Chels | 1 - 0 | Karela UnitedKarela United |
| 12 Mar 22 | r20 | Accra LionsAccra Lions | 1 - 0 | Dreams FCDreams FC |
| 13 Mar 22 | r20 | Aduana StarsAduana Stars | 1 - 0 | Hearts of OakHearts of Oak |
| 13 Mar 22 | r20 | Great OlympicsGreat Olympic | 1 - 0 | Legon CitiesLegon Cities |
| 13 Mar 22 | r20 | MedeamaMedeama | 1 - 0 | Eleven WondersEleven Wonder |
| 13 Mar 22 | r20 | Elmina SharksElmina Sharks | 2 - 3 | Bechem UnitedBechem United |
| 13 Mar 22 | r20 | WAFAWAFA | 1 - 0 | Real TamaleReal Tamale |
| 13 Mar 22 | r20 | Asante KotokoAsante Kotoko | 5 - 0 | Bibiani Gold StarsBibiani Gold |
| |
| 18 Mar 22 | r21 | Karela UnitedKarela United | 1 - 1 | MedeamaMedeama |
| 20 Mar 22 | r21 | Dreams FCDreams FC | 5 - 2 | Great OlympicsGreat Olympic |
| 20 Mar 22 | r21 | Legon CitiesLegon Cities | 2 - 1 | WAFAWAFA |
| 20 Mar 22 | r21 | Bechem UnitedBechem United | 1 - 0 | Accra LionsAccra Lions |
| 20 Mar 22 | r21 | Real TamaleReal Tamale | 1 - 1 | Aduana StarsAduana Stars |
| 20 Mar 22 | r21 | Bibiani Gold StarsBibiani Gold | 1 - 0 | Elmina SharksElmina Sharks |
| 20 Mar 22 | r21 | Hearts of OakHearts of Oak | 2 - 1 | Ashanti GoldAshanti Gold |
| 21 Mar 22 | r21 | Eleven WondersEleven Wonder | 0 - 0 | Asante KotokoAsante Kotoko |
| |
| 30 Mar 22 | r22 | Dreams FCDreams FC | 0 - 0 | Bechem UnitedBechem United |
| 30 Mar 22 | r22 | Aduana StarsAduana Stars | 1 - 1 | Legon CitiesLegon Cities |
| 30 Mar 22 | r22 | Berekum ChelseaBerekum Chels | 0 - 0 | Hearts of OakHearts of Oak |
| 30 Mar 22 | r22 | Great OlympicsGreat Olympic | 2 - 2 | WAFAWAFA |
| 30 Mar 22 | r22 | Elmina SharksElmina Sharks | 2 - 0 | Eleven WondersEleven Wonder |
| 30 Mar 22 | r22 | Ashanti GoldAshanti Gold | 4 - 0 | Real TamaleReal Tamale |
| 31 Mar 22 | r22 | MedeamaMedeama | 1 - 0 | King FaisalKing Faisal |
| 31 Mar 22 | r22 | Asante KotokoAsante Kotoko | 1 - 1 | Karela UnitedKarela United |
| 31 Mar 22 | r22 | Accra LionsAccra Lions | 1 - 0 | Bibiani Gold StarsBibiani Gold |
| |
| 02 Apr 22 | r23 | Hearts of OakHearts of Oak | 1 - 0 | MedeamaMedeama |
| 03 Apr 22 | r23 | Legon CitiesLegon Cities | 2 - 0 | Ashanti GoldAshanti Gold |
| 03 Apr 22 | r23 | King FaisalKing Faisal | 0 - 1 | Asante KotokoAsante Kotoko |
| 03 Apr 22 | r23 | WAFAWAFA | 0 - 0 | Aduana StarsAduana Stars |
| 03 Apr 22 | r23 | Karela UnitedKarela United | 3 - 1 | Elmina SharksElmina Sharks |
| 03 Apr 22 | r23 | Eleven WondersEleven Wonder | 2 - 0 | Accra LionsAccra Lions |
| 03 Apr 22 | r23 | Bibiani Gold StarsBibiani Gold | 1 - 0 | Dreams FCDreams FC |
| 04 Apr 22 | r23 | Bechem UnitedBechem United | 1 - 0 | Great OlympicsGreat Olympic |
| 04 Apr 22 | r23 | Real TamaleReal Tamale | 3 - 2 | Berekum ChelseaBerekum Chels |
| |
| 07 Apr 22 | r21 | King FaisalKing Faisal | 0 - 1 | Berekum ChelseaBerekum Chels |
| |
| 09 Apr 22 | r24 | Ashanti GoldAshanti Gold | 6 - 0 | WAFAWAFA |
| 09 Apr 22 | r24 | Accra LionsAccra Lions | 1 - 0 | Karela UnitedKarela United |
| 10 Apr 22 | r24 | Dreams FCDreams FC | 1 - 1 | Eleven WondersEleven Wonder |
| 10 Apr 22 | r24 | Berekum ChelseaBerekum Chels | 1 - 0 | Legon CitiesLegon Cities |
| 10 Apr 22 | r24 | Great OlympicsGreat Olympic | 2 - 1 | Aduana StarsAduana Stars |
| 10 Apr 22 | r24 | Elmina SharksElmina Sharks | 1 - 0 | King FaisalKing Faisal |
| 10 Apr 22 | r24 | Asante KotokoAsante Kotoko | 1 - 0 | Hearts of OakHearts of Oak |
| 10 Apr 22 | r24 | Bechem UnitedBechem United | 1 - 0 | Bibiani Gold StarsBibiani Gold |
| 10 Apr 22 | r24 | MedeamaMedeama | 2 - 1 | Real TamaleReal Tamale |
| |
| 17 Apr 22 | r25 | Hearts of OakHearts of Oak | 1 - 1 | Elmina SharksElmina Sharks |
| 17 Apr 22 | r25 | Eleven WondersEleven Wonder | 3 - 2 | Bechem UnitedBechem United |
| 17 Apr 22 | r25 | Aduana StarsAduana Stars | 0 - 0 | Ashanti GoldAshanti Gold |
| 17 Apr 22 | r25 | Legon CitiesLegon Cities | 3 - 1 | MedeamaMedeama |
| 17 Apr 22 | r25 | WAFAWAFA | 3 - 2 | Berekum ChelseaBerekum Chels |
| 17 Apr 22 | r25 | Karela UnitedKarela United | 1 - 0 | Dreams FCDreams FC |
| 17 Apr 22 | r25 | Real TamaleReal Tamale | 2 - 1 | Asante KotokoAsante Kotoko |
| 17 Apr 22 | r25 | Bibiani Gold StarsBibiani Gold | 2 - 1 | Great OlympicsGreat Olympic |
| 17 Apr 22 | r25 | King FaisalKing Faisal | 0 - 1 | Accra LionsAccra Lions |
| |
| 22 Apr 22 | r26 | Accra LionsAccra Lions | 0 - 3 | Hearts of OakHearts of Oak |
| 22 Apr 22 | r26 | Accra LionsAccra Lions | 0 - 3 | Hearts of OakHearts of Oak |
| 23 Apr 22 | r26 | Great OlympicsGreat Olympic | 0 - 1 | Ashanti GoldAshanti Gold |
| 24 Apr 22 | r26 | Dreams FCDreams FC | 1 - 1 | King FaisalKing Faisal |
| 24 Apr 22 | r26 | Berekum ChelseaBerekum Chels | 1 - 0 | Aduana StarsAduana Stars |
| 24 Apr 22 | r26 | MedeamaMedeama | 1 - 0 | WAFAWAFA |
| 24 Apr 22 | r26 | Asante KotokoAsante Kotoko | 1 - 3 | Legon CitiesLegon Cities |
| 24 Apr 22 | r26 | Bibiani Gold StarsBibiani Gold | 1 - 0 | Eleven WondersEleven Wonder |
| 24 Apr 22 | r26 | Elmina SharksElmina Sharks | 1 - 1 | Real TamaleReal Tamale |
| 25 Apr 22 | r26  | Bechem UnitedBechem United | 1 - 1 | Karela UnitedKarela United |
| |
| 30 Apr 22 | r27 | Eleven WondersEleven Wonder | 0 - 0 | Great OlympicsGreat Olympic |
| 30 Apr 22 | r27 | WAFAWAFA | 0 - 1 | Asante KotokoAsante Kotoko |
| 01 May 22 | r27 | Hearts of OakHearts of Oak | 3 - 1 | Dreams FCDreams FC |
| 01 May 22 | r27 | Legon CitiesLegon Cities | 2 - 0 | Elmina SharksElmina Sharks |
| 01 May 22 | r27 | King FaisalKing Faisal | 2 - 2 | Bechem UnitedBechem United |
| 01 May 22 | r27 | Ashanti GoldAshanti Gold | 5 - 1 | Berekum ChelseaBerekum Chels |
| 01 May 22 | r27 | Real TamaleReal Tamale | 2 - 0 | Accra LionsAccra Lions |
| 01 May 22 | r27 | Karela UnitedKarela United | 2 - 0 | Bibiani Gold StarsBibiani Gold |
| 02 May 22 | r27 | Aduana StarsAduana Stars | 1 - 1 | MedeamaMedeama |
| |
| 06 May 22 | r28 | Great OlympicsGreat Olympic | 2 - 0 | Berekum ChelseaBerekum Chels |
| 07 May 22 | r28 | Bechem UnitedBechem United | 1 - 1 | Hearts of OakHearts of Oak |
| 08 May 22 | r28 | Eleven WondersEleven Wonder | 2 - 1 | Karela UnitedKarela United |
| 08 May 22 | r28 | MedeamaMedeama | 2 - 0 | Ashanti GoldAshanti Gold |
| 08 May 22 | r28 | Elmina SharksElmina Sharks | 2 - 2 | WAFAWAFA |
| 08 May 22 | r28 | Asante KotokoAsante Kotoko | 1 - 1 | Aduana StarsAduana Stars |
| 08 May 22 | r28 | Dreams FCDreams FC | 2 - 2 | Real TamaleReal Tamale |
| 08 May 22 | r28 | Bibiani Gold StarsBibiani Gold | 2 - 1 | King FaisalKing Faisal |
| 09 May 22 | r28 | Accra LionsAccra Lions | 1 - 0 | Legon CitiesLegon Cities |
| |
| 18 May 22 | r29 | Aduana StarsAduana Stars | 0 - 0 | Elmina SharksElmina Sharks |
| 18 May 22 | r29 | Legon CitiesLegon Cities | 2 - 1 | Dreams FCDreams FC |
| 18 May 22 | r29 | Berekum ChelseaBerekum Chels | 0 - 0 | MedeamaMedeama |
| 18 May 22 | r29 | King FaisalKing Faisal | 1 - 0 | Eleven WondersEleven Wonder |
| 18 May 22 | r29 | Karela UnitedKarela United | 1 - 0 | Great OlympicsGreat Olympic |
| 18 May 22 | r29 | Hearts of OakHearts of Oak | 1 - 0 | Bibiani Gold StarsBibiani Gold |
| 18 May 22 | r29 | Real TamaleReal Tamale | 2 - 2 | Bechem UnitedBechem United |
| 18 May 22 | r29 | WAFAWAFA | 0 - 1 | Accra LionsAccra Lions |
| |
| 21 May 22 | r30 | Great OlympicsGreat Olympic | 1 - 2 | MedeamaMedeama |
| 22 May 22 | r30 | Dreams FCDreams FC | 1 - 1 | WAFAWAFA |
| 22 May 22 | r30 | Bechem UnitedBechem United | 0 - 0 | Legon CitiesLegon Cities |
| 22 May 22 | r30 | Elmina SharksElmina Sharks | 1 - 3 | Ashanti GoldAshanti Gold |
| 22 May 22 | r30 | Karela UnitedKarela United | 1 - 1 | King FaisalKing Faisal |
| 22 May 22 | r30 | Asante KotokoAsante Kotoko | 0 - 1 | Berekum ChelseaBerekum Chels |
| 22 May 22 | r30 | Bibiani Gold StarsBibiani Gold | 2 - 0 | Real TamaleReal Tamale |
| 22 May 22 | r30 | Accra LionsAccra Lions | 0 - 0 | Aduana StarsAduana Stars |
| |
| 29 May 22 | r31 | Aduana StarsAduana Stars | 0 - 0 | Dreams FCDreams FC |
| 29 May 22 | r31 | Berekum ChelseaBerekum Chels | 3 - 0 | Elmina SharksElmina Sharks |
| 29 May 22 | r31 | King FaisalKing Faisal | 1 - 1 | Great OlympicsGreat Olympic |
| 29 May 22 | r31 | WAFAWAFA | 1 - 1 | Bechem UnitedBechem United |
| 29 May 22 | r31 | MedeamaMedeama | 0 - 2 | Asante KotokoAsante Kotoko |
| 29 May 22 | r31 | Legon CitiesLegon Cities | 1 - 1 | Bibiani Gold StarsBibiani Gold |
| 29 May 22 | r31 | Real TamaleReal Tamale | 0 - 0 | Eleven WondersEleven Wonder |
| 29 May 22 | r31 | Ashanti GoldAshanti Gold | 2 - 2 | Accra LionsAccra Lions |
| 30 May 22 | r31 | Hearts of OakHearts of Oak | 1 - 1 | Karela UnitedKarela United |
| |
| 02 Jun 22 | r29 | Ashanti GoldAshanti Gold | 1 - 1 | Asante KotokoAsante Kotoko |
| |
| 04 Jun 22 | r32 | Accra LionsAccra Lions | 2 - 0 | Berekum ChelseaBerekum Chels |
| 05 Jun 22 | r32 | Eleven WondersEleven Wonder | 0 - 0 | Legon CitiesLegon Cities |
| 05 Jun 22 | r32 | Dreams FCDreams FC | 1 - 0 | Ashanti GoldAshanti Gold |
| 05 Jun 22 | r32 | Bechem UnitedBechem United | 1 - 0 | Aduana StarsAduana Stars |
| 05 Jun 22 | r32 | Great OlympicsGreat Olympic | 0 - 1 | Asante KotokoAsante Kotoko |
| 05 Jun 22 | r32 | Elmina SharksElmina Sharks | 1 - 3 | MedeamaMedeama |
| 05 Jun 22 | r32 | Bibiani Gold StarsBibiani Gold | 3 - 4 | WAFAWAFA |
| 05 Jun 22 | r32 | Karela UnitedKarela United | 5 - 1 | Real TamaleReal Tamale |
| 05 Jun 22 | r32 | King FaisalKing Faisal | 1 - 0 | Hearts of OakHearts of Oak |
| |
| 08 Jun 22 | r30 | Eleven WondersEleven Wonder | 2 - 1 | Hearts of OakHearts of Oak |
| |
| 12 Jun 22 | r33 | Great OlympicsGreat Olympic | 3 - 0 | Hearts of OakHearts of Oak |
| 12 Jun 22 | r33 | Legon CitiesLegon Cities | 0 - 0 | Karela UnitedKarela United |
| 12 Jun 22 | r33 | Berekum ChelseaBerekum Chels | 0 - 1 | Dreams FCDreams FC |
| 12 Jun 22 | r33 | WAFAWAFA | 1 - 0 | Eleven WondersEleven Wonder |
| 12 Jun 22 | r33 | Ashanti GoldAshanti Gold | 2 - 1 | Bechem UnitedBechem United |
| 12 Jun 22 | r33 | Aduana StarsAduana Stars | 0 - 1 | Bibiani Gold StarsBibiani Gold |
| 12 Jun 22 | r33 | Real TamaleReal Tamale | 1 - 0 | King FaisalKing Faisal |
| 12 Jun 22 | r33 | MedeamaMedeama | 2 - 1 | Accra LionsAccra Lions |
| 12 Jun 22 | r33 | Asante KotokoAsante Kotoko | 3 - 0 | Elmina SharksElmina Sharks |
| |
| 18 Jun 22 | r34 | Accra LionsAccra Lions | 1 - 1 | Asante KotokoAsante Kotoko |
| 19 Jun 22 | r34 | Eleven WondersEleven Wonder | 2 - 1 | Aduana StarsAduana Stars |
| 19 Jun 22 | r34 | Dreams FCDreams FC | 2 - 0 | MedeamaMedeama |
| 19 Jun 22 | r34 | Bechem UnitedBechem United | 1 - 1 | Berekum ChelseaBerekum Chels |
| 19 Jun 22 | r34 | King FaisalKing Faisal | 2 - 1 | Legon CitiesLegon Cities |
| 19 Jun 22 | r34 | Elmina SharksElmina Sharks | 2 - 2 | Great OlympicsGreat Olympic |
| 19 Jun 22 | r34 | Karela UnitedKarela United | 1 - 0 | WAFAWAFA |
| 19 Jun 22 | r34 | Hearts of OakHearts of Oak | 1 - 4 | Real TamaleReal Tamale |
| 19 Jun 22 | r34 | Bibiani Gold StarsBibiani Gold | 2 - 2 | Ashanti GoldAshanti Gold |
Team 2021-2022 Schedules
Aduana Stars
Asante Kotoko
Basake Holy Stars
Bechem United
Berekum Chelsea
Bibiani Gold Stars
Dreams FC
Eleven Wonders
Heart of Lions
Hearts of Oak
Hohoe United
Karela United
Medeama
Nations FC
Samartex
Swedru All Blacks
Vision
Young Apostles
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