| 15 Feb 22 | r01  | Deportes Santa CruzDeportes Sant | 1 - 1 | Deportes TemucoDeportes Temu |
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| 22 Feb 22 | r02 | Santiago MorningSantiago Morn | 2 - 1 | Deportes Santa CruzDeportes Sant |
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| 01 Mar 22 | r03 | Deportes Santa CruzDeportes Sant | 1 - 2 | MagallanesMagallanes |
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| 07 Mar 22 | r04 | Fernández VialFernández Via | 1 - 0 | Deportes Santa CruzDeportes Sant |
| |
| 23 Mar 22 | r06 | Deportes Santa CruzDeportes Sant | 1 - 1 | BarnecheaBarnechea |
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| 03 Apr 22 | r07 | Deportes IquiqueDeportes Iqui | 2 - 2 | Deportes Santa CruzDeportes Sant |
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| 11 Apr 22 | r08 | Deportes Santa CruzDeportes Sant | 0 - 0 | Universidad de ConcepciónUniversidad d |
| |
| 21 Apr 22 | r10 | Rangers de TalcaRangers de Ta | 2 - 1 | Deportes Santa CruzDeportes Sant |
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| 26 Apr 22 | r11 | Deportes Santa CruzDeportes Sant | 2 - 2 | Deportes CopiapóDeportes Copi |
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| 30 Apr 22 | r12 | Deportes Puerto MonttDeportes Puer | 3 - 0 | Deportes Santa CruzDeportes Sant |
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| 08 May 22 | r13 | Deportes Santa CruzDeportes Sant | 1 - 0 | RecoletaRecoleta |
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| 12 May 22 | r14 | Unión San FelipeUnión San Fel | 2 - 1 | Deportes Santa CruzDeportes Sant |
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| 18 May 22 | r15 | Deportes Santa CruzDeportes Sant | 2 - 0 | San Luis de QuillotaSan Luis de Q |
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| 22 May 22 | r16 | Deportes MelipillaDeportes Meli | 1 - 0 | Deportes Santa CruzDeportes Sant |
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| 27 May 22 | r17 | Deportes Santa CruzDeportes Sant | 2 - 0 | Santiago WanderersSantiago Wand |
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| 02 Jun 22 | r05 | CobreloaCobreloa | 1 - 0 | Deportes Santa CruzDeportes Sant |
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| 02 Jul 22 | r18 | Deportes TemucoDeportes Temu | 1 - 1 | Deportes Santa CruzDeportes Sant |
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| 08 Jul 22 | r19 | Deportes Santa CruzDeportes Sant | 1 - 0 | Santiago MorningSantiago Morn |
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| 16 Jul 22 | r20 | MagallanesMagallanes | 0 - 0 | Deportes Santa CruzDeportes Sant |
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| 26 Jul 22 | r21 | Deportes Santa CruzDeportes Sant | 2 - 0 | Fernández VialFernández Via |
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| 01 Aug 22 | r22 | Deportes Santa CruzDeportes Sant | 1 - 1 | CobreloaCobreloa |
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| 08 Aug 22 | r23 | BarnecheaBarnechea | 2 - 0 | Deportes Santa CruzDeportes Sant |
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| 15 Aug 22 | r24 | Deportes Santa CruzDeportes Sant | 1 - 0 | Deportes IquiqueDeportes Iqui |
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| 24 Aug 22 | r25 | Universidad de ConcepciónUniversidad d | 3 - 2 | Deportes Santa CruzDeportes Sant |
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| 06 Sep 22 | r27 | Deportes Santa CruzDeportes Sant | 2 - 1 | Rangers de TalcaRangers de Ta |
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| 13 Sep 22 | r28 | Deportes CopiapóDeportes Copi | 4 - 2 | Deportes Santa CruzDeportes Sant |
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| 26 Sep 22 | r29 | Deportes Santa CruzDeportes Sant | 0 - 2 | Deportes Puerto MonttDeportes Puer |
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| 03 Oct 22 | r30 | RecoletaRecoleta | 2 - 1 | Deportes Santa CruzDeportes Sant |
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| 11 Oct 22 | r31 | Deportes Santa CruzDeportes Sant | 4 - 0 | Unión San FelipeUnión San Fel |
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| 16 Oct 22 | r32 | San Luis de QuillotaSan Luis de Q | 0 - 0 | Deportes Santa CruzDeportes Sant |
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| 24 Oct 22 | r33 | Deportes Santa CruzDeportes Sant | 2 - 1 | Deportes MelipillaDeportes Meli |
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| 02 Nov 22 | r34 | Santiago WanderersSantiago Wand | 2 - 0 | Deportes Santa CruzDeportes Sant |
Team 2022 Schedules
Cobreloa
Curicó Unido
Deportes Antofagasta
Deportes Copiapó
Deportes Iquique
Deportes Puerto Montt
Deportes Recoleta
Deportes Santa Cruz
Deportes Temuco
Magallanes
Rangers de Talca
San Luis de Quillota
San Marcos de Arica
Santiago Wanderers
Unión Española
Unión San Felipe
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