| 08 Aug 21 | r01  | MotaguaMotagua | 3 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 13 Aug 21 | r02 | Platense Puerto CortésPlatense Puer | 1 - 1 | Honduras ProgresoHonduras Prog |
| |
| 15 Aug 21 | r03 | Platense Puerto CortésPlatense Puer | 0 - 2 | Real EspañaReal España |
| |
| 22 Aug 21 | r04 | Lobos UPNFMLobos UPNFM | 3 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 27 Aug 21 | r05 | Platense Puerto CortésPlatense Puer | 3 - 1 | CD MarathónCD Marathón |
| |
| 30 Aug 21 | r06 | Real Sociedad TocoaReal Sociedad | 1 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 02 Sep 21 | r07 | CD OlimpiaCD Olimpia | 3 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 12 Sep 21 | r08 | Platense Puerto CortésPlatense Puer | 1 - 4 | VidaVida |
| |
| 16 Sep 21 | r09 | CD VictoriaCD Victoria | 2 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 19 Sep 21 | r10 | Platense Puerto CortésPlatense Puer | 2 - 3 | Real Sociedad TocoaReal Sociedad |
| |
| 26 Sep 21 | r11 | Platense Puerto CortésPlatense Puer | 2 - 3 | Lobos UPNFMLobos UPNFM |
| |
| 03 Oct 21 | r12 | Honduras ProgresoHonduras Prog | 4 - 2 | Platense Puerto CortésPlatense Puer |
| |
| 10 Oct 21 | r13 | Platense Puerto CortésPlatense Puer | 2 - 3 | MotaguaMotagua |
| |
| 17 Oct 21 | r14 | Real EspañaReal España | 2 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 24 Oct 21 | r15 | CD MarathónCD Marathón | 1 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 28 Oct 21 | r16 | Platense Puerto CortésPlatense Puer | 1 - 2 | CD VictoriaCD Victoria |
| |
| 31 Oct 21 | r17 | VidaVida | 3 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 10 Nov 21 | r18 | Platense Puerto CortésPlatense Puer | 1 - 4 | CD OlimpiaCD Olimpia |
| |
| 21 Jan 22 | r01  | CD MarathónCD Marathón | 1 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 23 Jan 22 | r02 | Platense Puerto CortésPlatense Puer | 2 - 1 | Real EspañaReal España |
| |
| 06 Feb 22 | r03 | Platense Puerto CortésPlatense Puer | 0 - 2 | CD VictoriaCD Victoria |
| |
| 10 Feb 22 | r04 | Lobos UPNFMLobos UPNFM | 1 - 2 | Platense Puerto CortésPlatense Puer |
| |
| 13 Feb 22 | r05 | Platense Puerto CortésPlatense Puer | 1 - 2 | VidaVida |
| |
| 20 Feb 22 | r06 | Real Sociedad TocoaReal Sociedad | 1 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 27 Feb 22 | r07 | MotaguaMotagua | 2 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 03 Mar 22 | r08 | Platense Puerto CortésPlatense Puer | 0 - 3 | CD OlimpiaCD Olimpia |
| |
| 06 Mar 22 | r09 | Platense Puerto CortésPlatense Puer | 0 - 0 | Honduras ProgresoHonduras Prog |
| |
| 13 Mar 22 | r10 | CD VictoriaCD Victoria | 0 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 20 Mar 22 | r11 | Real EspañaReal España | 3 - 2 | Platense Puerto CortésPlatense Puer |
| |
| 03 Apr 22 | r12 | Platense Puerto CortésPlatense Puer | 1 - 0 | Lobos UPNFMLobos UPNFM |
| |
| 07 Apr 22 | r13 | VidaVida | 1 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 11 Apr 22 | r14 | Platense Puerto CortésPlatense Puer | 1 - 0 | Real Sociedad TocoaReal Sociedad |
| |
| 14 Apr 22 | r15 | CD OlimpiaCD Olimpia | 0 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 21 Apr 22 | r16 | Platense Puerto CortésPlatense Puer | 1 - 0 | CD MarathónCD Marathón |
| |
| 25 Apr 22 | r17 | Platense Puerto CortésPlatense Puer | 0 - 0 | MotaguaMotagua |
| |
| 01 May 22 | r18 | Honduras ProgresoHonduras Prog | 3 - 1 | Platense Puerto CortésPlatense Puer |
Team 2021-2022 Schedules
Atlético Independiente
CD Olimpia
Choloma
Estrella Roja de Danlí
Génesis Policía Nacional
Juticalpa
Lobos UPNFM
Marathón
Motagua
Olancho
Platense Puerto Cortés
Real España
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