| 08 Aug 21 | r01  | VidaVida | 1 - 1 | Lobos UPNFMLobos UPNFM |
| 08 Aug 21 | r01 | Real Sociedad TocoaReal Sociedad | 0 - 3 | CD OlimpiaCD Olimpia |
| 08 Aug 21 | r01 | MotaguaMotagua | 3 - 0 | Platense Puerto CortésPlatense Puer |
| 09 Aug 21 | r01 | Honduras ProgresoHonduras Prog | 1 - 2 | CD MarathónCD Marathón |
| |
| 11 Aug 21 | r02 | CD MarathónCD Marathón | 5 - 1 | Lobos UPNFMLobos UPNFM |
| 12 Aug 21 | r02 | Real Sociedad TocoaReal Sociedad | 3 - 3 | VidaVida |
| 12 Aug 21 | r02 | CD VictoriaCD Victoria | 0 - 1 | MotaguaMotagua |
| 12 Aug 21 | r02 | CD OlimpiaCD Olimpia | 1 - 1 | Real EspañaReal España |
| 13 Aug 21 | r02 | Platense Puerto CortésPlatense Puer | 1 - 1 | Honduras ProgresoHonduras Prog |
| |
| 14 Aug 21 | r03 | CD MarathónCD Marathón | 2 - 0 | MotaguaMotagua |
| 15 Aug 21 | r03 | CD VictoriaCD Victoria | 0 - 2 | Real Sociedad TocoaReal Sociedad |
| 15 Aug 21 | r03 | Lobos UPNFMLobos UPNFM | 3 - 0 | Honduras ProgresoHonduras Prog |
| 15 Aug 21 | r03 | Platense Puerto CortésPlatense Puer | 0 - 2 | Real EspañaReal España |
| 15 Aug 21 | r03 | CD OlimpiaCD Olimpia | 1 - 1 | VidaVida |
| |
| 22 Aug 21 | r04 | Real EspañaReal España | 1 - 1 | Real Sociedad TocoaReal Sociedad |
| 22 Aug 21 | r04 | Lobos UPNFMLobos UPNFM | 3 - 0 | Platense Puerto CortésPlatense Puer |
| 22 Aug 21 | r04 | Honduras ProgresoHonduras Prog | 2 - 0 | CD VictoriaCD Victoria |
| 22 Aug 21 | r04 | VidaVida | 2 - 0 | CD MarathónCD Marathón |
| 22 Aug 21 | r04 | MotaguaMotagua | 3 - 2 | CD OlimpiaCD Olimpia |
| |
| 26 Aug 21 | r05 | Real EspañaReal España | 5 - 3 | Lobos UPNFMLobos UPNFM |
| 26 Aug 21 | r05 | Real Sociedad TocoaReal Sociedad | 3 - 3 | MotaguaMotagua |
| 26 Aug 21 | r05 | VidaVida | 2 - 0 | CD VictoriaCD Victoria |
| 26 Aug 21 | r05 | CD OlimpiaCD Olimpia | 2 - 1 | Honduras ProgresoHonduras Prog |
| 27 Aug 21 | r05 | Platense Puerto CortésPlatense Puer | 3 - 1 | CD MarathónCD Marathón |
| |
| 29 Aug 21 | r06 | Honduras ProgresoHonduras Prog | 1 - 1 | VidaVida |
| 29 Aug 21 | r06 | CD VictoriaCD Victoria | 0 - 3 | CD OlimpiaCD Olimpia |
| 29 Aug 21 | r06 | CD MarathónCD Marathón | 0 - 1 | Real EspañaReal España |
| 30 Aug 21 | r06 | Real Sociedad TocoaReal Sociedad | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 31 Aug 21 | r06 | MotaguaMotagua | 0 - 0 | Lobos UPNFMLobos UPNFM |
| |
| 02 Sep 21 | r07 | CD OlimpiaCD Olimpia | 3 - 0 | Platense Puerto CortésPlatense Puer |
| 04 Sep 21 | r07 | Lobos UPNFMLobos UPNFM | 3 - 0 | CD VictoriaCD Victoria |
| 04 Sep 21 | r07 | CD MarathónCD Marathón | 2 - 1 | Real Sociedad TocoaReal Sociedad |
| 05 Sep 21 | r07 | Honduras ProgresoHonduras Prog | 0 - 3 | MotaguaMotagua |
| 05 Sep 21 | r07 | VidaVida | 1 - 0 | Real EspañaReal España |
| |
| 12 Sep 21 | r17 | Lobos UPNFMLobos UPNFM | 0 - 0 | CD OlimpiaCD Olimpia |
| |
| 12 Sep 21 | r08 | Real EspañaReal España | 2 - 1 | MotaguaMotagua |
| 12 Sep 21 | r08 | CD VictoriaCD Victoria | 1 - 0 | CD MarathónCD Marathón |
| 12 Sep 21 | r08 | Real Sociedad TocoaReal Sociedad | 1 - 0 | Honduras ProgresoHonduras Prog |
| 12 Sep 21 | r08 | Platense Puerto CortésPlatense Puer | 1 - 4 | VidaVida |
| |
| 16 Sep 21 | r09 | Lobos UPNFMLobos UPNFM | 2 - 0 | Real Sociedad TocoaReal Sociedad |
| 16 Sep 21 | r09 | Honduras ProgresoHonduras Prog | 1 - 1 | Real EspañaReal España |
| 16 Sep 21 | r09 | CD VictoriaCD Victoria | 2 - 0 | Platense Puerto CortésPlatense Puer |
| 16 Sep 21 | r09 | MotaguaMotagua | 2 - 1 | VidaVida |
| 16 Sep 21 | r09 | CD MarathónCD Marathón | 3 - 1 | CD OlimpiaCD Olimpia |
| |
| 19 Sep 21 | r10 | CD OlimpiaCD Olimpia | 4 - 0 | CD VictoriaCD Victoria |
| 19 Sep 21 | r10 | Lobos UPNFMLobos UPNFM | 2 - 2 | MotaguaMotagua |
| 19 Sep 21 | r10 | Platense Puerto CortésPlatense Puer | 2 - 3 | Real Sociedad TocoaReal Sociedad |
| 20 Sep 21 | r10 | Real EspañaReal España | 0 - 1 | CD MarathónCD Marathón |
| 20 Sep 21 | r10 | VidaVida | 1 - 0 | Honduras ProgresoHonduras Prog |
| |
| 23 Sep 21 | r11 | CD VictoriaCD Victoria | 1 - 2 | Honduras ProgresoHonduras Prog |
| 25 Sep 21 | r11 | CD MarathónCD Marathón | 1 - 2 | VidaVida |
| 26 Sep 21 | r11 | Platense Puerto CortésPlatense Puer | 2 - 3 | Lobos UPNFMLobos UPNFM |
| 27 Sep 21 | r11 | Real Sociedad TocoaReal Sociedad | 0 - 4 | Real EspañaReal España |
| |
| 03 Oct 21 | r12 | Honduras ProgresoHonduras Prog | 4 - 2 | Platense Puerto CortésPlatense Puer |
| 03 Oct 21 | r12 | Real EspañaReal España | 1 - 1 | CD OlimpiaCD Olimpia |
| 03 Oct 21 | r12 | VidaVida | 2 - 1 | Real Sociedad TocoaReal Sociedad |
| 03 Oct 21 | r12 | Lobos UPNFMLobos UPNFM | 1 - 1 | CD MarathónCD Marathón |
| 03 Oct 21 | r12 | MotaguaMotagua | 5 - 0 | CD VictoriaCD Victoria |
| |
| 09 Oct 21 | r13 | CD MarathónCD Marathón | 2 - 1 | Honduras ProgresoHonduras Prog |
| 10 Oct 21 | r13 | Lobos UPNFMLobos UPNFM | 0 - 0 | VidaVida |
| 10 Oct 21 | r13 | CD OlimpiaCD Olimpia | 4 - 0 | Real Sociedad TocoaReal Sociedad |
| 10 Oct 21 | r13 | Platense Puerto CortésPlatense Puer | 2 - 3 | MotaguaMotagua |
| 10 Oct 21 | r13 | CD VictoriaCD Victoria | 0 - 2 | Real EspañaReal España |
| |
| 17 Oct 21 | r14 | Real EspañaReal España | 2 - 1 | Platense Puerto CortésPlatense Puer |
| 17 Oct 21 | r14 | Honduras ProgresoHonduras Prog | 0 - 1 | Lobos UPNFMLobos UPNFM |
| 17 Oct 21 | r14 | VidaVida | 2 - 1 | CD OlimpiaCD Olimpia |
| 17 Oct 21 | r14 | Real Sociedad TocoaReal Sociedad | 2 - 1 | CD VictoriaCD Victoria |
| 17 Oct 21 | r14 | MotaguaMotagua | 2 - 1 | CD MarathónCD Marathón |
| |
| 21 Oct 21 | r01 | Real EspañaReal España | 1 - 1 | CD VictoriaCD Victoria |
| |
| 24 Oct 21 | r15 | Honduras ProgresoHonduras Prog | 0 - 2 | CD OlimpiaCD Olimpia |
| 24 Oct 21 | r15 | CD VictoriaCD Victoria | 1 - 2 | VidaVida |
| 24 Oct 21 | r15 | CD MarathónCD Marathón | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 24 Oct 21 | r15 | MotaguaMotagua | 5 - 1 | Real Sociedad TocoaReal Sociedad |
| 24 Oct 21 | r15 | Lobos UPNFMLobos UPNFM | 1 - 2 | Real EspañaReal España |
| |
| 27 Oct 21 | r16 | Real Sociedad TocoaReal Sociedad | 0 - 3 | Lobos UPNFMLobos UPNFM |
| 28 Oct 21 | r16 | CD OlimpiaCD Olimpia | 1 - 0 | CD MarathónCD Marathón |
| 28 Oct 21 | r16 | Real EspañaReal España | 4 - 1 | Honduras ProgresoHonduras Prog |
| 28 Oct 21 | r16 | Platense Puerto CortésPlatense Puer | 1 - 2 | CD VictoriaCD Victoria |
| 28 Oct 21 | r16 | VidaVida | 1 - 1 | MotaguaMotagua |
| 28 Oct 21 | r16 | CD OlimpiaCD Olimpia | 1 - 0 | CD MarathónCD Marathón |
| |
| 30 Oct 21 | r17 | CD MarathónCD Marathón | 0 - 0 | CD VictoriaCD Victoria |
| 30 Oct 21 | r17 | CD OlimpiaCD Olimpia | 2 - 1 | Lobos UPNFMLobos UPNFM |
| 31 Oct 21 | r17 | MotaguaMotagua | 0 - 1 | Real EspañaReal España |
| 31 Oct 21 | r17 | VidaVida | 3 - 1 | Platense Puerto CortésPlatense Puer |
| 01 Nov 21 | r17 | Honduras ProgresoHonduras Prog | 2 - 1 | Real Sociedad TocoaReal Sociedad |
| |
| 07 Nov 21 | r11 | CD OlimpiaCD Olimpia | 0 - 0 | MotaguaMotagua |
| |
| 10 Nov 21 | r18 | Platense Puerto CortésPlatense Puer | 1 - 4 | CD OlimpiaCD Olimpia |
| 10 Nov 21 | r18 | Real Sociedad TocoaReal Sociedad | 0 - 3 | CD MarathónCD Marathón |
| 10 Nov 21 | r18 | MotaguaMotagua | 3 - 2 | Honduras ProgresoHonduras Prog |
| 10 Nov 21 | r18 | Real EspañaReal España | 2 - 1 | VidaVida |
| 10 Nov 21 | r18 | CD VictoriaCD Victoria | 1 - 0 | Lobos UPNFMLobos UPNFM |
| |
| 19 Nov 21 | r00 | CD MarathónCD Marathón | 1 - 0 | CD OlimpiaCD Olimpia |
| 19 Nov 21 | r00 | Lobos UPNFMLobos UPNFM | 1 - 2 | MotaguaMotagua |
| 21 Nov 21 | r00 | MotaguaMotagua | 3 - 1 | Lobos UPNFMLobos UPNFM |
| 21 Nov 21 | r00 | CD OlimpiaCD Olimpia | 3 - 0 | CD MarathónCD Marathón |
| 05 Dec 21 | r00 | MotaguaMotagua | 1 - 1 | Real EspañaReal España |
| 05 Dec 21 | r00 | CD OlimpiaCD Olimpia | 2 - 0 | VidaVida |
| 12 Dec 21 | r00 | Real EspañaReal España | 2 - 0 | MotaguaMotagua |
| 12 Dec 21 | r00 | VidaVida | 2 - 1 | CD OlimpiaCD Olimpia |
| 19 Dec 21 | r00 | CD OlimpiaCD Olimpia | 2 - 0 | Real EspañaReal España |
Team 2021-2022 Schedules
CD Olimpia
CD Victoria
Choloma
Génesis
Juticalpa
Lobos UPNFM
Marathón
Motagua
Olancho
Real España
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