| 28 Jul 21 | r01    | Sporting San JoseSporting San | 1 - 1 | GuanacastecaGuanacasteca |
| |
| 01 Aug 21 | r02 | AlajuelenseAlajuelense | 3 - 3 | Sporting San JoseSporting San |
| |
| 09 Aug 21 | r03 | Sporting San JoseSporting San | 2 - 1 | Santos de GuápilesSantos de Guá |
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| 14 Aug 21 | r05 | Sporting San JoseSporting San | 4 - 1 | CartaginésCartaginés |
| |
| 18 Aug 21 | r06 | GuadalupeGuadalupe | 2 - 2 | Sporting San JoseSporting San |
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| 25 Aug 21 | r07 | Sporting San JoseSporting San | 0 - 0 | AD San CarlosAD San Carlos |
| |
| 28 Aug 21 | r08 | GreciaGrecia | 1 - 1 | Sporting San JoseSporting San |
| |
| 01 Sep 21 | r04 | JicaralJicaral | 1 - 3 | Sporting San JoseSporting San |
| |
| 08 Sep 21 | r09 | Sporting San JoseSporting San | 4 - 0 | Deportivo SaprissaDeportivo Sap |
| |
| 11 Sep 21 | r10 | Sporting San JoseSporting San | 1 - 1 | Pérez ZeledónPérez Zeledón |
| |
| 17 Sep 21 | r11 | CS HeredianoCS Herediano | 3 - 0 | Sporting San JoseSporting San |
| |
| 20 Sep 21 | r12 | GuanacastecaGuanacasteca | 1 - 0 | Sporting San JoseSporting San |
| |
| 26 Sep 21 | r13 | Sporting San JoseSporting San | 0 - 3 | AlajuelenseAlajuelense |
| |
| 03 Oct 21 | r14 | Santos de GuápilesSantos de Guá | 5 - 1 | Sporting San JoseSporting San |
| |
| 12 Oct 21 | r15 | Sporting San JoseSporting San | 2 - 1 | JicaralJicaral |
| 12 Oct 21 | r15 | Sporting San JoseSporting San | 2 - 1 | JicaralJicaral |
| |
| 19 Oct 21 | r16 | CartaginésCartaginés | 1 - 0 | Sporting San JoseSporting San |
| |
| 23 Oct 21 | r17 | Sporting San JoseSporting San | 2 - 0 | GuadalupeGuadalupe |
| |
| 28 Oct 21 | r18 | AD San CarlosAD San Carlos | 3 - 1 | Sporting San JoseSporting San |
| |
| 01 Nov 21 | r19 | Sporting San JoseSporting San | 2 - 1 | GreciaGrecia |
| 01 Nov 21 | r19 | Sporting San JoseSporting San | 2 - 1 | GreciaGrecia |
| |
| 21 Nov 21 | r20 | Deportivo SaprissaDeportivo Sap | 5 - 1 | Sporting San JoseSporting San |
| |
| 23 Nov 21 | r21 | Pérez ZeledónPérez Zeledón | 1 - 0 | Sporting San JoseSporting San |
| |
| 28 Nov 21 | r22 | Sporting San JoseSporting San | 0 - 2 | CS HeredianoCS Herediano |
| |
| 21 Jan 22 | r03 | Sporting San JoseSporting San | 2 - 2 | GuadalupeGuadalupe |
| |
| 04 Feb 22 | r04 | CartaginésCartaginés | 2 - 1 | Sporting San JoseSporting San |
| |
| 08 Feb 22 | r05 | Sporting San JoseSporting San | 3 - 0 | JicaralJicaral |
| |
| 15 Feb 22 | r06  | CS HeredianoCS Herediano | 0 - 1 | Sporting San JoseSporting San |
| |
| 17 Feb 22 | r01 | Sporting San JoseSporting San | 2 - 1 | AlajuelenseAlajuelense |
| |
| 20 Feb 22 | r07 | GuanacastecaGuanacasteca | 2 - 0 | Sporting San JoseSporting San |
| |
| 26 Feb 22 | r08 | Sporting San JoseSporting San | 1 - 1 | Pérez ZeledónPérez Zeledón |
| |
| 02 Mar 22 | r09 | GreciaGrecia | 0 - 1 | Sporting San JoseSporting San |
| |
| 06 Mar 22 | r10 | Sporting San JoseSporting San | 0 - 1 | Deportivo SaprissaDeportivo Sap |
| |
| 20 Mar 22 | r02 | Santos de GuápilesSantos de Guá | 2 - 3 | Sporting San JoseSporting San |
| |
| 01 Apr 22 | r11 | Sporting San JoseSporting San | 4 - 0 | AD San CarlosAD San Carlos |
| |
| 06 Apr 22 | r12 | AlajuelenseAlajuelense | 1 - 1 | Sporting San JoseSporting San |
| |
| 12 Apr 22 | r13 | Sporting San JoseSporting San | 1 - 1 | Santos de GuápilesSantos de Guá |
| |
| 17 Apr 22 | r14 | GuadalupeGuadalupe | 4 - 2 | Sporting San JoseSporting San |
| |
| 21 Apr 22 | r15 | Sporting San JoseSporting San | 2 - 2 | CartaginésCartaginés |
| |
| 24 Apr 22 | r16 | JicaralJicaral | 2 - 0 | Sporting San JoseSporting San |
| |
| 28 Apr 22 | r17 | Sporting San JoseSporting San | 0 - 2 | CS HeredianoCS Herediano |
| |
| 01 May 22 | r18 | Sporting San JoseSporting San | 0 - 0 | GuanacastecaGuanacasteca |
| |
| 05 May 22 | r19 | Pérez ZeledónPérez Zeledón | 0 - 1 | Sporting San JoseSporting San |
| |
| 08 May 22 | r20 | Sporting San JoseSporting San | 3 - 2 | GreciaGrecia |
| |
| 12 May 22 | r21 | Deportivo SaprissaDeportivo Sap | 1 - 0 | Sporting San JoseSporting San |
| |
| 15 May 22 | r22 | AD San CarlosAD San Carlos | 2 - 1 | Sporting San JoseSporting San |
Team 2021-2022 Schedules
AD San Carlos
Alajuelense
Cartaginés
Deportivo Saprissa
Guadalupe
Herediano
Municipal Liberia
Pérez Zeledón
Puntarenas
Sporting San Jose
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