| 28 Jul 21 | r01    | Pérez ZeledónPérez Zeledón | 1 - 1 | JicaralJicaral |
| 28 Jul 21 | r01 | Sporting San JoseSporting San | 1 - 1 | GuanacastecaGuanacasteca |
| 28 Jul 21 | r01 | Deportivo SaprissaDeportivo Sap | 3 - 0 | Santos de GuápilesSantos de Guá |
| 28 Jul 21 | r01 | GreciaGrecia | 4 - 0 | CartaginésCartaginés |
| 29 Jul 21 | r01 | CS HeredianoCS Herediano | 0 - 1 | GuadalupeGuadalupe |
| 29 Jul 21 | r01 | AD San CarlosAD San Carlos | 2 - 2 | AlajuelenseAlajuelense |
| |
| 31 Jul 21 | r02 | Pérez ZeledónPérez Zeledón | 0 - 3 | Deportivo SaprissaDeportivo Sap |
| 31 Jul 21 | r02  | CartaginésCartaginés | 1 - 1 | GuanacastecaGuanacasteca |
| 31 Jul 21 | r02 | Santos de GuápilesSantos de Guá | 1 - 0 | GreciaGrecia |
| 01 Aug 21 | r02 | AlajuelenseAlajuelense | 3 - 3 | Sporting San JoseSporting San |
| 01 Aug 21 | r02 | GuadalupeGuadalupe | 1 - 1 | AD San CarlosAD San Carlos |
| 01 Aug 21 | r02 | JicaralJicaral | 3 - 2 | CS HeredianoCS Herediano |
| |
| 07 Aug 21 | r03 | AD San CarlosAD San Carlos | 1 - 1 | Pérez ZeledónPérez Zeledón |
| 07 Aug 21 | r03 | GuanacastecaGuanacasteca | 0 - 1 | GuadalupeGuadalupe |
| 08 Aug 21 | r03 | AlajuelenseAlajuelense | 2 - 3 | CartaginésCartaginés |
| 08 Aug 21 | r03 | GreciaGrecia | 0 - 0 | JicaralJicaral |
| 09 Aug 21 | r03 | Deportivo SaprissaDeportivo Sap | 2 - 3 | CS HeredianoCS Herediano |
| 09 Aug 21 | r03 | Sporting San JoseSporting San | 2 - 1 | Santos de GuápilesSantos de Guá |
| |
| 11 Aug 21 | r04 | CartaginésCartaginés | 5 - 1 | AD San CarlosAD San Carlos |
| 11 Aug 21 | r04 | GuadalupeGuadalupe | 1 - 1 | Deportivo SaprissaDeportivo Sap |
| 11 Aug 21 | r04 | GuanacastecaGuanacasteca | 0 - 2 | GreciaGrecia |
| 12 Aug 21 | r04 | CS HeredianoCS Herediano | 1 - 0 | Pérez ZeledónPérez Zeledón |
| 12 Aug 21 | r04 | Santos de GuápilesSantos de Guá | 2 - 1 | AlajuelenseAlajuelense |
| |
| 14 Aug 21 | r05 | AD San CarlosAD San Carlos | 0 - 0 | JicaralJicaral |
| 14 Aug 21 | r05 | Deportivo SaprissaDeportivo Sap | 1 - 0 | GreciaGrecia |
| 14 Aug 21 | r05 | Sporting San JoseSporting San | 4 - 1 | CartaginésCartaginés |
| 15 Aug 21 | r05 | Pérez ZeledónPérez Zeledón | 1 - 1 | GuadalupeGuadalupe |
| 15 Aug 21 | r05 | Santos de GuápilesSantos de Guá | 2 - 1 | GuanacastecaGuanacasteca |
| 15 Aug 21 | r05 | AlajuelenseAlajuelense | 4 - 1 | CS HeredianoCS Herediano |
| |
| 17 Aug 21 | r06 | GreciaGrecia | 1 - 0 | Pérez ZeledónPérez Zeledón |
| 17 Aug 21 | r06 | GuanacastecaGuanacasteca | 1 - 2 | AlajuelenseAlajuelense |
| 18 Aug 21 | r06 | CS HeredianoCS Herediano | 2 - 0 | AD San CarlosAD San Carlos |
| 18 Aug 21 | r06 | CartaginésCartaginés | 1 - 0 | Deportivo SaprissaDeportivo Sap |
| 18 Aug 21 | r06 | GuadalupeGuadalupe | 2 - 2 | Sporting San JoseSporting San |
| 21 Aug 21 | r06 | JicaralJicaral | 1 - 1 | Santos de GuápilesSantos de Guá |
| |
| 24 Aug 21 | r07 | GuanacastecaGuanacasteca | 2 - 1 | Pérez ZeledónPérez Zeledón |
| 25 Aug 21 | r07 | CartaginésCartaginés | 0 - 1 | GuadalupeGuadalupe |
| 25 Aug 21 | r07 | Deportivo SaprissaDeportivo Sap | 4 - 0 | JicaralJicaral |
| 25 Aug 21 | r07 | Sporting San JoseSporting San | 0 - 0 | AD San CarlosAD San Carlos |
| 26 Aug 21 | r07 | Santos de GuápilesSantos de Guá | 2 - 1 | CS HeredianoCS Herediano |
| 26 Aug 21 | r07 | AlajuelenseAlajuelense | 1 - 0 | GreciaGrecia |
| |
| 28 Aug 21 | r08 | GreciaGrecia | 1 - 1 | Sporting San JoseSporting San |
| 28 Aug 21 | r08 | JicaralJicaral | 0 - 0 | GuadalupeGuadalupe |
| 29 Aug 21 | r08 | CS HeredianoCS Herediano | 2 - 0 | CartaginésCartaginés |
| 29 Aug 21 | r08 | Deportivo SaprissaDeportivo Sap | 4 - 2 | AlajuelenseAlajuelense |
| 29 Aug 21 | r08 | Pérez ZeledónPérez Zeledón | 1 - 1 | Santos de GuápilesSantos de Guá |
| 30 Aug 21 | r08 | AD San CarlosAD San Carlos | 0 - 1 | GuanacastecaGuanacasteca |
| |
| 01 Sep 21 | r04 | JicaralJicaral | 1 - 3 | Sporting San JoseSporting San |
| |
| 07 Sep 21 | r09 | GuadalupeGuadalupe | 0 - 2 | GreciaGrecia |
| 08 Sep 21 | r09 | AlajuelenseAlajuelense | 2 - 0 | JicaralJicaral |
| 08 Sep 21 | r09 | Sporting San JoseSporting San | 4 - 0 | Deportivo SaprissaDeportivo Sap |
| 08 Sep 21 | r09 | CartaginésCartaginés | 2 - 1 | Pérez ZeledónPérez Zeledón |
| 08 Sep 21 | r09 | Santos de GuápilesSantos de Guá | 2 - 2 | AD San CarlosAD San Carlos |
| 09 Sep 21 | r09 | GuanacastecaGuanacasteca | 2 - 1 | CS HeredianoCS Herediano |
| |
| 11 Sep 21 | r10 | Sporting San JoseSporting San | 1 - 1 | Pérez ZeledónPérez Zeledón |
| 12 Sep 21 | r10 | GuadalupeGuadalupe | 2 - 4 | AlajuelenseAlajuelense |
| 12 Sep 21 | r10 | CartaginésCartaginés | 1 - 2 | Santos de GuápilesSantos de Guá |
| 12 Sep 21 | r10 | GreciaGrecia | 1 - 2 | CS HeredianoCS Herediano |
| 12 Sep 21 | r10 | GuanacastecaGuanacasteca | 1 - 1 | JicaralJicaral |
| 13 Sep 21 | r10 | AD San CarlosAD San Carlos | 1 - 0 | Deportivo SaprissaDeportivo Sap |
| |
| 15 Sep 21 | r11 | Pérez ZeledónPérez Zeledón | 1 - 0 | AlajuelenseAlajuelense |
| 15 Sep 21 | r11 | JicaralJicaral | 0 - 3 | CartaginésCartaginés |
| 15 Sep 21 | r11 | GreciaGrecia | 3 - 2 | AD San CarlosAD San Carlos |
| 17 Sep 21 | r11 | Santos de GuápilesSantos de Guá | 2 - 2 | GuadalupeGuadalupe |
| 17 Sep 21 | r11 | CS HeredianoCS Herediano | 3 - 0 | Sporting San JoseSporting San |
| 17 Sep 21 | r11 | Deportivo SaprissaDeportivo Sap | 1 - 1 | GuanacastecaGuanacasteca |
| |
| 18 Sep 21 | r12 | AlajuelenseAlajuelense | 2 - 2 | AD San CarlosAD San Carlos |
| 18 Sep 21 | r12 | JicaralJicaral | 3 - 0 | Pérez ZeledónPérez Zeledón |
| 19 Sep 21 | r12 | CartaginésCartaginés | 1 - 1 | GreciaGrecia |
| 19 Sep 21 | r12 | GuadalupeGuadalupe | 0 - 2 | CS HeredianoCS Herediano |
| 20 Sep 21 | r12 | Santos de GuápilesSantos de Guá | 3 - 3 | Deportivo SaprissaDeportivo Sap |
| 20 Sep 21 | r12 | GuanacastecaGuanacasteca | 1 - 0 | Sporting San JoseSporting San |
| |
| 25 Sep 21 | r13 | GuanacastecaGuanacasteca | 2 - 1 | CartaginésCartaginés |
| 26 Sep 21 | r13 | AD San CarlosAD San Carlos | 4 - 2 | GuadalupeGuadalupe |
| 26 Sep 21 | r13 | CS HeredianoCS Herediano | 1 - 0 | JicaralJicaral |
| 26 Sep 21 | r13 | Sporting San JoseSporting San | 0 - 3 | AlajuelenseAlajuelense |
| 26 Sep 21 | r13 | GreciaGrecia | 3 - 2 | Santos de GuápilesSantos de Guá |
| 27 Sep 21 | r13 | Deportivo SaprissaDeportivo Sap | 3 - 0 | Pérez ZeledónPérez Zeledón |
| |
| 01 Oct 21 | r14 | GuadalupeGuadalupe | 1 - 1 | GuanacastecaGuanacasteca |
| 02 Oct 21 | r14 | JicaralJicaral | 3 - 1 | GreciaGrecia |
| 03 Oct 21 | r14 | Pérez ZeledónPérez Zeledón | 1 - 1 | AD San CarlosAD San Carlos |
| 03 Oct 21 | r14 | CartaginésCartaginés | 1 - 0 | AlajuelenseAlajuelense |
| 03 Oct 21 | r14 | Santos de GuápilesSantos de Guá | 5 - 1 | Sporting San JoseSporting San |
| 04 Oct 21 | r14 | CS HeredianoCS Herediano | 2 - 1 | Deportivo SaprissaDeportivo Sap |
| |
| 12 Oct 21 | r15 | Sporting San JoseSporting San | 2 - 1 | JicaralJicaral |
| 12 Oct 21 | r15 | Sporting San JoseSporting San | 2 - 1 | JicaralJicaral |
| 12 Oct 21 | r15 | Pérez ZeledónPérez Zeledón | 0 - 1 | CS HeredianoCS Herediano |
| 13 Oct 21 | r15 | AD San CarlosAD San Carlos | 0 - 1 | CartaginésCartaginés |
| 13 Oct 21 | r15 | AlajuelenseAlajuelense | 1 - 0 | Santos de GuápilesSantos de Guá |
| 13 Oct 21 | r15 | GreciaGrecia | 3 - 1 | GuanacastecaGuanacasteca |
| 15 Oct 21 | r15 | Deportivo SaprissaDeportivo Sap | 4 - 0 | GuadalupeGuadalupe |
| |
| 17 Oct 21 | r16 | CS HeredianoCS Herediano | 0 - 0 | AlajuelenseAlajuelense |
| 17 Oct 21 | r16 | GreciaGrecia | 1 - 1 | Deportivo SaprissaDeportivo Sap |
| 17 Oct 21 | r16 | JicaralJicaral | 0 - 4 | AD San CarlosAD San Carlos |
| 17 Oct 21 | r16 | JicaralJicaral | 0 - 4 | AD San CarlosAD San Carlos |
| 17 Oct 21 | r16 | GuanacastecaGuanacasteca | 1 - 3 | Santos de GuápilesSantos de Guá |
| 18 Oct 21 | r16 | GuadalupeGuadalupe | 0 - 1 | Pérez ZeledónPérez Zeledón |
| 19 Oct 21 | r16 | CartaginésCartaginés | 1 - 0 | Sporting San JoseSporting San |
| |
| 23 Oct 21 | r17 | AD San CarlosAD San Carlos | 0 - 0 | CS HeredianoCS Herediano |
| 23 Oct 21 | r17 | Pérez ZeledónPérez Zeledón | 3 - 1 | GreciaGrecia |
Team 2021-2022 Schedules
AD San Carlos
Alajuelense
Cartaginés
Deportivo Saprissa
Guadalupe
Herediano
Municipal Liberia
Pérez Zeledón
Puntarenas
Sporting San Jose
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