| 28 Jul 21 | r01    | GreciaGrecia | 4 - 0 | CartaginésCartaginés |
| |
| 31 Jul 21 | r02  | CartaginésCartaginés | 1 - 1 | GuanacastecaGuanacasteca |
| |
| 08 Aug 21 | r03 | AlajuelenseAlajuelense | 2 - 3 | CartaginésCartaginés |
| |
| 11 Aug 21 | r04 | CartaginésCartaginés | 5 - 1 | AD San CarlosAD San Carlos |
| |
| 14 Aug 21 | r05 | Sporting San JoseSporting San | 4 - 1 | CartaginésCartaginés |
| |
| 18 Aug 21 | r06 | CartaginésCartaginés | 1 - 0 | Deportivo SaprissaDeportivo Sap |
| |
| 25 Aug 21 | r07 | CartaginésCartaginés | 0 - 1 | GuadalupeGuadalupe |
| |
| 29 Aug 21 | r08 | CS HeredianoCS Herediano | 2 - 0 | CartaginésCartaginés |
| |
| 08 Sep 21 | r09 | CartaginésCartaginés | 2 - 1 | Pérez ZeledónPérez Zeledón |
| |
| 12 Sep 21 | r10 | CartaginésCartaginés | 1 - 2 | Santos de GuápilesSantos de Guá |
| |
| 15 Sep 21 | r11 | JicaralJicaral | 0 - 3 | CartaginésCartaginés |
| |
| 19 Sep 21 | r12 | CartaginésCartaginés | 1 - 1 | GreciaGrecia |
| |
| 25 Sep 21 | r13 | GuanacastecaGuanacasteca | 2 - 1 | CartaginésCartaginés |
| |
| 03 Oct 21 | r14 | CartaginésCartaginés | 1 - 0 | AlajuelenseAlajuelense |
| |
| 13 Oct 21 | r15 | AD San CarlosAD San Carlos | 0 - 1 | CartaginésCartaginés |
| |
| 19 Oct 21 | r16 | CartaginésCartaginés | 1 - 0 | Sporting San JoseSporting San |
| |
| 24 Oct 21 | r17 | Deportivo SaprissaDeportivo Sap | 1 - 1 | CartaginésCartaginés |
| |
| 27 Oct 21 | r18 | GuadalupeGuadalupe | 1 - 1 | CartaginésCartaginés |
| |
| 31 Oct 21 | r19 | CartaginésCartaginés | 0 - 1 | CS HeredianoCS Herediano |
| |
| 20 Nov 21 | r20 | Pérez ZeledónPérez Zeledón | 3 - 0 | CartaginésCartaginés |
| |
| 24 Nov 21 | r21 | Santos de GuápilesSantos de Guá | 1 - 2 | CartaginésCartaginés |
| |
| 28 Nov 21 | r22 | CartaginésCartaginés | 4 - 0 | JicaralJicaral |
| |
| 13 Jan 22 | r01 | GuadalupeGuadalupe | 3 - 2 | CartaginésCartaginés |
| |
| 16 Jan 22 | r02 | CartaginésCartaginés | 2 - 1 | Pérez ZeledónPérez Zeledón |
| |
| 23 Jan 22 | r03 | Deportivo SaprissaDeportivo Sap | 2 - 4 | CartaginésCartaginés |
| |
| 04 Feb 22 | r04 | CartaginésCartaginés | 2 - 1 | Sporting San JoseSporting San |
| |
| 10 Feb 22 | r05 | AlajuelenseAlajuelense | 3 - 2 | CartaginésCartaginés |
| |
| 13 Feb 22 | r06 | GreciaGrecia | 2 - 0 | CartaginésCartaginés |
| |
| 20 Feb 22 | r07 | CartaginésCartaginés | 1 - 0 | CS HeredianoCS Herediano |
| |
| 28 Feb 22 | r08 | Santos de GuápilesSantos de Guá | 1 - 3 | CartaginésCartaginés |
| |
| 02 Mar 22 | r09 | CartaginésCartaginés | 1 - 1 | AD San CarlosAD San Carlos |
| |
| 06 Mar 22 | r10 | GuanacastecaGuanacasteca | 1 - 1 | CartaginésCartaginés |
| |
| 01 Apr 22 | r11 | CartaginésCartaginés | 0 - 0 | JicaralJicaral |
| |
| 08 Apr 22 | r12 | CartaginésCartaginés | 4 - 1 | GuadalupeGuadalupe |
| |
| 11 Apr 22 | r13 | Pérez ZeledónPérez Zeledón | 3 - 0 | CartaginésCartaginés |
| |
| 17 Apr 22 | r14 | CartaginésCartaginés | 3 - 1 | Deportivo SaprissaDeportivo Sap |
| |
| 21 Apr 22 | r15 | Sporting San JoseSporting San | 2 - 2 | CartaginésCartaginés |
| |
| 24 Apr 22 | r16 | CartaginésCartaginés | 1 - 2 | AlajuelenseAlajuelense |
| |
| 27 Apr 22 | r17 | CartaginésCartaginés | 4 - 0 | GreciaGrecia |
| |
| 01 May 22 | r18 | CS HeredianoCS Herediano | 4 - 1 | CartaginésCartaginés |
| |
| 04 May 22 | r19 | CartaginésCartaginés | 4 - 1 | Santos de GuápilesSantos de Guá |
| |
| 09 May 22 | r20 | AD San CarlosAD San Carlos | 3 - 2 | CartaginésCartaginés |
| |
| 12 May 22 | r21 | CartaginésCartaginés | 3 - 0 | GuanacastecaGuanacasteca |
| |
| 15 May 22 | r22 | JicaralJicaral | 4 - 3 | CartaginésCartaginés |
| |
| 19 Jun 22 | r00 | CartaginésCartaginés | 1 - 0 | CS HeredianoCS Herediano |
| 22 Jun 22 | r00 | CS HeredianoCS Herediano | 1 - 1 | CartaginésCartaginés |
| 26 Jun 22 | r00 | CartaginésCartaginés | 0 - 0 | AlajuelenseAlajuelense |
| 01 Jul 22 | r00 | AlajuelenseAlajuelense | 1 - 1 | CartaginésCartaginés |
| 04 Jul 22 | r00 | CartaginésCartaginés | 1 - 0 | AlajuelenseAlajuelense |
| 07 Jul 22 | r00 | AlajuelenseAlajuelense | 1 - 1 | CartaginésCartaginés |
Team 2021-2022 Schedules
AD San Carlos
Alajuelense
Cartaginés
Deportivo Saprissa
Guadalupe
Herediano
Municipal Liberia
Pérez Zeledón
Puntarenas
Sporting San Jose
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