| 29 Jul 21 | r01    | AD San CarlosAD San Carlos | 2 - 2 | AlajuelenseAlajuelense |
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| 01 Aug 21 | r02 | GuadalupeGuadalupe | 1 - 1 | AD San CarlosAD San Carlos |
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| 07 Aug 21 | r03 | AD San CarlosAD San Carlos | 1 - 1 | Pérez ZeledónPérez Zeledón |
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| 11 Aug 21 | r04 | CartaginésCartaginés | 5 - 1 | AD San CarlosAD San Carlos |
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| 14 Aug 21 | r05 | AD San CarlosAD San Carlos | 0 - 0 | JicaralJicaral |
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| 18 Aug 21 | r06 | CS HeredianoCS Herediano | 2 - 0 | AD San CarlosAD San Carlos |
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| 25 Aug 21 | r07 | Sporting San JoseSporting San | 0 - 0 | AD San CarlosAD San Carlos |
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| 30 Aug 21 | r08 | AD San CarlosAD San Carlos | 0 - 1 | GuanacastecaGuanacasteca |
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| 08 Sep 21 | r09 | Santos de GuápilesSantos de Guá | 2 - 2 | AD San CarlosAD San Carlos |
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| 13 Sep 21 | r10 | AD San CarlosAD San Carlos | 1 - 0 | Deportivo SaprissaDeportivo Sap |
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| 15 Sep 21 | r11 | GreciaGrecia | 3 - 2 | AD San CarlosAD San Carlos |
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| 18 Sep 21 | r12  | AlajuelenseAlajuelense | 2 - 2 | AD San CarlosAD San Carlos |
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| 26 Sep 21 | r13 | AD San CarlosAD San Carlos | 4 - 2 | GuadalupeGuadalupe |
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| 03 Oct 21 | r14 | Pérez ZeledónPérez Zeledón | 1 - 1 | AD San CarlosAD San Carlos |
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| 13 Oct 21 | r15 | AD San CarlosAD San Carlos | 0 - 1 | CartaginésCartaginés |
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| 17 Oct 21 | r16 | JicaralJicaral | 0 - 4 | AD San CarlosAD San Carlos |
| 17 Oct 21 | r16 | JicaralJicaral | 0 - 4 | AD San CarlosAD San Carlos |
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| 23 Oct 21 | r17 | AD San CarlosAD San Carlos | 0 - 0 | CS HeredianoCS Herediano |
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| 28 Oct 21 | r18 | AD San CarlosAD San Carlos | 3 - 1 | Sporting San JoseSporting San |
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| 01 Nov 21 | r19 | GuanacastecaGuanacasteca | 0 - 1 | AD San CarlosAD San Carlos |
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| 20 Nov 21 | r20 | AD San CarlosAD San Carlos | 2 - 4 | Santos de GuápilesSantos de Guá |
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| 24 Nov 21 | r21 | Deportivo SaprissaDeportivo Sap | 3 - 0 | AD San CarlosAD San Carlos |
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| 28 Nov 21 | r22 | AD San CarlosAD San Carlos | 1 - 3 | GreciaGrecia |
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| 16 Jan 22 | r02 | Deportivo SaprissaDeportivo Sap | 1 - 2 | AD San CarlosAD San Carlos |
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| 22 Jan 22 | r03 | AD San CarlosAD San Carlos | 1 - 1 | Pérez ZeledónPérez Zeledón |
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| 04 Feb 22 | r04 | GuadalupeGuadalupe | 3 - 1 | AD San CarlosAD San Carlos |
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| 11 Feb 22 | r05 | AD San CarlosAD San Carlos | 1 - 1 | CS HeredianoCS Herediano |
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| 15 Feb 22 | r06 | AD San CarlosAD San Carlos | 3 - 1 | GuanacastecaGuanacasteca |
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| 19 Feb 22 | r07 | GreciaGrecia | 0 - 1 | AD San CarlosAD San Carlos |
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| 26 Feb 22 | r08 | AD San CarlosAD San Carlos | 1 - 1 | JicaralJicaral |
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| 02 Mar 22 | r09 | CartaginésCartaginés | 1 - 1 | AD San CarlosAD San Carlos |
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| 07 Mar 22 | r10 | AD San CarlosAD San Carlos | 1 - 1 | AlajuelenseAlajuelense |
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| 13 Mar 22 | r01 | AD San CarlosAD San Carlos | 1 - 0 | Santos de GuápilesSantos de Guá |
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| 01 Apr 22 | r11 | Sporting San JoseSporting San | 4 - 0 | AD San CarlosAD San Carlos |
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| 06 Apr 22 | r12 | Santos de GuápilesSantos de Guá | 1 - 1 | AD San CarlosAD San Carlos |
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| 10 Apr 22 | r13 | AD San CarlosAD San Carlos | 4 - 1 | Deportivo SaprissaDeportivo Sap |
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| 14 Apr 22 | r14 | Pérez ZeledónPérez Zeledón | 1 - 0 | AD San CarlosAD San Carlos |
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| 20 Apr 22 | r15 | AD San CarlosAD San Carlos | 2 - 1 | GuadalupeGuadalupe |
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| 24 Apr 22 | r16 | CS HeredianoCS Herediano | 1 - 1 | AD San CarlosAD San Carlos |
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| 27 Apr 22 | r17 | GuanacastecaGuanacasteca | 2 - 3 | AD San CarlosAD San Carlos |
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| 01 May 22 | r18 | AD San CarlosAD San Carlos | 2 - 2 | GreciaGrecia |
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| 04 May 22 | r19 | JicaralJicaral | 2 - 1 | AD San CarlosAD San Carlos |
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| 09 May 22 | r20 | AD San CarlosAD San Carlos | 3 - 2 | CartaginésCartaginés |
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| 13 May 22 | r21 | AlajuelenseAlajuelense | 1 - 0 | AD San CarlosAD San Carlos |
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| 15 May 22 | r22 | AD San CarlosAD San Carlos | 2 - 1 | Sporting San JoseSporting San |
Team 2021-2022 Schedules
AD San Carlos
Alajuelense
Cartaginés
Deportivo Saprissa
Guadalupe
Herediano
Municipal Liberia
Pérez Zeledón
Puntarenas
Sporting San Jose
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