| 28 Nov 20 | r46  | San Fernando CDSan Fernando | 1 - 2 | Algeciras CFAlgeciras CF |
| 29 Nov 20 | r46 | LinenseLinense | 0 - 0 | Las Palmas AtléticoLas Palmas At |
| 29 Nov 20 | r46 | UCAM MurciaUCAM Murcia | 1 - 0 | Lorca DeportivaLorca Deporti |
| 29 Nov 20 | r46 | Recreativo GranadaRecreativo Gr | 0 - 0 | Betis DeportivoBetis Deporti |
| 29 Nov 20 | r46 | TamaraceiteTamaraceite | 1 - 0 | Cadiz BCadiz B |
| 29 Nov 20 | r46 | CD MarinoCD Marino | 0 - 1 | Atlético SanluqueñoAtlético Sanl |
| 29 Nov 20 | r46 | YeclanoYeclano | 1 - 2 | MurciaMurcia |
| 29 Nov 20 | r46 | Linares DeportivoLinares Depor | 2 - 0 | CordobaCordoba |
| 29 Nov 20 | r46 | Sevilla AtleticoSevilla Atlet | 1 - 1 | El EjidoEl Ejido |
| 29 Nov 20 | r46 | MarbellaMarbella | 2 - 0 | RecreativoRecreativo |
| 08 May 21 | r46 | CD MarinoCD Marino | 0 - 1 | Lorca DeportivaLorca Deporti |
| 09 May 21 | r46 | Linares DeportivoLinares Depor | 1 - 0 | Atlético SanluqueñoAtlético Sanl |
| 09 May 21 | r46 | UCAM MurciaUCAM Murcia | 1 - 2 | Algeciras CFAlgeciras CF |
| 09 May 21 | r46 | Betis DeportivoBetis Deporti | 2 - 1 | San Fernando CDSan Fernando |
| 09 May 21 | r46 | CordobaCordoba | 2 - 1 | Cadiz BCadiz B |
| 09 May 21 | r46 | Sevilla AtleticoSevilla Atlet | 3 - 1 | LinenseLinense |
| 09 May 21 | r46 | MurciaMurcia | 2 - 1 | TamaraceiteTamaraceite |
| 09 May 21 | r46 | Las Palmas AtléticoLas Palmas At | 4 - 2 | YeclanoYeclano |
| 09 May 21 | r46 | RecreativoRecreativo | 1 - 2 | El EjidoEl Ejido |
| 09 May 21 | r46 | MarbellaMarbella | 0 - 0 | Recreativo GranadaRecreativo Gr |
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