| 18 Oct 20 | r41  | Sevilla AtleticoSevilla Atlet | 0 - 1 | UCAM MurciaUCAM Murcia |
| 18 Oct 20 | r41 | Cadiz BCadiz B | 2 - 0 | Las Palmas AtléticoLas Palmas At |
| 18 Oct 20 | r41 | TamaraceiteTamaraceite | 0 - 0 | San Fernando CDSan Fernando |
| 18 Oct 20 | r41 | CD MarinoCD Marino | 0 - 1 | LinenseLinense |
| 18 Oct 20 | r41 | Atlético SanluqueñoAtlético Sanl | 1 - 1 | RecreativoRecreativo |
| 18 Oct 20 | r41 | Linares DeportivoLinares Depor | 0 - 0 | YeclanoYeclano |
| 18 Oct 20 | r41 | Algeciras CFAlgeciras CF | 0 - 0 | MarbellaMarbella |
| 18 Oct 20 | r41 | El EjidoEl Ejido | 3 - 0 | Betis DeportivoBetis Deporti |
| 18 Oct 20 | r41 | CordobaCordoba | 1 - 0 | Lorca DeportivaLorca Deporti |
| |
| 25 Oct 20 | r42 | LinenseLinense | 0 - 0 | TamaraceiteTamaraceite |
| 25 Oct 20 | r42 | MarbellaMarbella | 5 - 1 | CD MarinoCD Marino |
| 25 Oct 20 | r42 | Lorca DeportivaLorca Deporti | 2 - 2 | El EjidoEl Ejido |
| 25 Oct 20 | r42 | UCAM MurciaUCAM Murcia | 1 - 0 | Linares DeportivoLinares Depor |
| 25 Oct 20 | r42 | Las Palmas AtléticoLas Palmas At | 0 - 1 | Atlético SanluqueñoAtlético Sanl |
| 25 Oct 20 | r42 | RecreativoRecreativo | 0 - 1 | Algeciras CFAlgeciras CF |
| 25 Oct 20 | r42 | San Fernando CDSan Fernando | 0 - 1 | Cadiz BCadiz B |
| 25 Oct 20 | r42 | YeclanoYeclano | 1 - 3 | CordobaCordoba |
| |
| 01 Nov 20 | r43 | RecreativoRecreativo | 2 - 0 | Las Palmas AtléticoLas Palmas At |
| 01 Nov 20 | r43 | Cadiz BCadiz B | 1 - 2 | LinenseLinense |
| 01 Nov 20 | r43 | TamaraceiteTamaraceite | 3 - 1 | MarbellaMarbella |
| 01 Nov 20 | r43 | Algeciras CFAlgeciras CF | 2 - 1 | CD MarinoCD Marino |
| 01 Nov 20 | r43 | CordobaCordoba | 0 - 0 | UCAM MurciaUCAM Murcia |
| 01 Nov 20 | r43 | MurciaMurcia | 1 - 1 | Sevilla AtleticoSevilla Atlet |
| 01 Nov 20 | r43 | El EjidoEl Ejido | 2 - 0 | YeclanoYeclano |
| 01 Nov 20 | r43 | Atlético SanluqueñoAtlético Sanl | 1 - 3 | San Fernando CDSan Fernando |
| 01 Nov 20 | r43 | Betis DeportivoBetis Deporti | 0 - 0 | Lorca DeportivaLorca Deporti |
| |
| 08 Nov 20 | r44 | LinenseLinense | 0 - 0 | Atlético SanluqueñoAtlético Sanl |
| 08 Nov 20 | r44 | Recreativo GranadaRecreativo Gr | 1 - 1 | CordobaCordoba |
| 08 Nov 20 | r44 | CD MarinoCD Marino | 0 - 0 | TamaraceiteTamaraceite |
| 08 Nov 20 | r44 | UCAM MurciaUCAM Murcia | 2 - 1 | El EjidoEl Ejido |
| 08 Nov 20 | r44 | Las Palmas AtléticoLas Palmas At | 0 - 1 | Algeciras CFAlgeciras CF |
| 08 Nov 20 | r44 | MarbellaMarbella | 0 - 0 | Cadiz BCadiz B |
| 08 Nov 20 | r44 | Lorca DeportivaLorca Deporti | 1 - 2 | MurciaMurcia |
| 08 Nov 20 | r44 | YeclanoYeclano | 1 - 1 | Betis DeportivoBetis Deporti |
| 08 Nov 20 | r44 | Sevilla AtleticoSevilla Atlet | 1 - 4 | Linares DeportivoLinares Depor |
| |
| 15 Nov 20 | r41 | MurciaMurcia | 1 - 2 | Recreativo GranadaRecreativo Gr |
| |
| 18 Nov 20 | r42 | Recreativo GranadaRecreativo Gr | 2 - 2 | Sevilla AtleticoSevilla Atlet |
| |
| 21 Nov 20 | r45 | CordobaCordoba | 1 - 2 | Sevilla AtleticoSevilla Atlet |
| 21 Nov 20 | r45 | Betis DeportivoBetis Deporti | 1 - 1 | UCAM MurciaUCAM Murcia |
| 21 Nov 20 | r45 | MurciaMurcia | 3 - 0 | Linares DeportivoLinares Depor |
| 22 Nov 20 | r45 | Cadiz BCadiz B | 3 - 1 | CD MarinoCD Marino |
| 22 Nov 20 | r45 | Las Palmas AtléticoLas Palmas At | 2 - 1 | San Fernando CDSan Fernando |
| 22 Nov 20 | r45 | RecreativoRecreativo | 2 - 0 | LinenseLinense |
| 22 Nov 20 | r45 | Atlético SanluqueñoAtlético Sanl | 2 - 1 | MarbellaMarbella |
| 22 Nov 20 | r45 | Algeciras CFAlgeciras CF | 2 - 1 | TamaraceiteTamaraceite |
| 22 Nov 20 | r45 | Lorca DeportivaLorca Deporti | 1 - 1 | YeclanoYeclano |
| 22 Nov 20 | r45 | El EjidoEl Ejido | 0 - 1 | Recreativo GranadaRecreativo Gr |
| |
| 25 Nov 20 | r42 | Betis DeportivoBetis Deporti | 2 - 1 | MurciaMurcia |
| |
| 25 Nov 20 | r43 | Linares DeportivoLinares Depor | 1 - 0 | Recreativo GranadaRecreativo Gr |
| |
| 28 Nov 20 | r46 | San Fernando CDSan Fernando | 1 - 2 | Algeciras CFAlgeciras CF |
| 29 Nov 20 | r46 | LinenseLinense | 0 - 0 | Las Palmas AtléticoLas Palmas At |
| 29 Nov 20 | r46 | UCAM MurciaUCAM Murcia | 1 - 0 | Lorca DeportivaLorca Deporti |
| 29 Nov 20 | r46 | Recreativo GranadaRecreativo Gr | 0 - 0 | Betis DeportivoBetis Deporti |
| 29 Nov 20 | r46 | TamaraceiteTamaraceite | 1 - 0 | Cadiz BCadiz B |
| 29 Nov 20 | r46 | CD MarinoCD Marino | 0 - 1 | Atlético SanluqueñoAtlético Sanl |
| 29 Nov 20 | r46 | YeclanoYeclano | 1 - 2 | MurciaMurcia |
| 29 Nov 20 | r46 | Linares DeportivoLinares Depor | 2 - 0 | CordobaCordoba |
| 29 Nov 20 | r46 | Sevilla AtleticoSevilla Atlet | 1 - 1 | El EjidoEl Ejido |
| 29 Nov 20 | r46 | MarbellaMarbella | 2 - 0 | RecreativoRecreativo |
| |
| 05 Dec 20 | r47 | RecreativoRecreativo | 6 - 0 | CD MarinoCD Marino |
| 05 Dec 20 | r47 | San Fernando CDSan Fernando | 2 - 1 | LinenseLinense |
| 06 Dec 20 | r47 | Las Palmas AtléticoLas Palmas At | 1 - 1 | MarbellaMarbella |
| 06 Dec 20 | r47 | Atlético SanluqueñoAtlético Sanl | 0 - 0 | TamaraceiteTamaraceite |
| 06 Dec 20 | r47 | Lorca DeportivaLorca Deporti | 2 - 2 | Recreativo GranadaRecreativo Gr |
| 06 Dec 20 | r47 | Betis DeportivoBetis Deporti | 3 - 0 | Sevilla AtleticoSevilla Atlet |
| 06 Dec 20 | r47 | El EjidoEl Ejido | 0 - 2 | Linares DeportivoLinares Depor |
| 06 Dec 20 | r47 | YeclanoYeclano | 0 - 2 | UCAM MurciaUCAM Murcia |
| 06 Dec 20 | r47 | MurciaMurcia | 0 - 1 | CordobaCordoba |
| |
| 09 Dec 20 | r44 | San Fernando CDSan Fernando | 1 - 0 | RecreativoRecreativo |
| |
| 12 Dec 20 | r48 | CD MarinoCD Marino | 0 - 0 | Las Palmas AtléticoLas Palmas At |
| 12 Dec 20 | r48 | Linares DeportivoLinares Depor | 1 - 1 | Betis DeportivoBetis Deporti |
| 13 Dec 20 | r48 | Sevilla AtleticoSevilla Atlet | 4 - 0 | Lorca DeportivaLorca Deporti |
| 13 Dec 20 | r48 | Recreativo GranadaRecreativo Gr | 2 - 0 | YeclanoYeclano |
| 13 Dec 20 | r48 | MurciaMurcia | 2 - 1 | UCAM MurciaUCAM Murcia |
| 13 Dec 20 | r48 | CordobaCordoba | 4 - 0 | El EjidoEl Ejido |
| 13 Dec 20 | r48 | MarbellaMarbella | 1 - 2 | San Fernando CDSan Fernando |
| |
| 19 Dec 20 | r47 | Algeciras CFAlgeciras CF | 2 - 0 | Cadiz BCadiz B |
| |
| 20 Dec 20 | r48 | TamaraceiteTamaraceite | 2 - 1 | RecreativoRecreativo |
| 03 Jan 21 | r48 | Algeciras CFAlgeciras CF | 1 - 1 | LinenseLinense |
| 03 Jan 21 | r48 | Cadiz BCadiz B | 1 - 2 | Atlético SanluqueñoAtlético Sanl |
| |
| 09 Jan 21 | r49 | UCAM MurciaUCAM Murcia | 2 - 1 | Recreativo GranadaRecreativo Gr |
| 10 Jan 21 | r49 | Atlético SanluqueñoAtlético Sanl | 2 - 0 | Algeciras CFAlgeciras CF |
| 10 Jan 21 | r49 | San Fernando CDSan Fernando | 2 - 3 | CD MarinoCD Marino |
| 10 Jan 21 | r49 | Lorca DeportivaLorca Deporti | 0 - 3 | Linares DeportivoLinares Depor |
| 10 Jan 21 | r49 | Las Palmas AtléticoLas Palmas At | 1 - 1 | TamaraceiteTamaraceite |
| 10 Jan 21 | r49 | Betis DeportivoBetis Deporti | 0 - 0 | CordobaCordoba |
| 10 Jan 21 | r49 | YeclanoYeclano | 3 - 1 | Sevilla AtleticoSevilla Atlet |
| 10 Jan 21 | r49 | El EjidoEl Ejido | 1 - 1 | MurciaMurcia |
| |
| 16 Jan 21 | r410 | LinenseLinense | 1 - 0 | CD MarinoCD Marino |
| 17 Jan 21 | r410 | RecreativoRecreativo | 1 - 0 | Atlético SanluqueñoAtlético Sanl |
| 17 Jan 21 | r410 | San Fernando CDSan Fernando | 1 - 0 | TamaraceiteTamaraceite |
| 17 Jan 21 | r410 | UCAM MurciaUCAM Murcia | 2 - 3 | Sevilla AtleticoSevilla Atlet |
| 17 Jan 21 | r410 | Recreativo GranadaRecreativo Gr | 0 - 1 | MurciaMurcia |
| 17 Jan 21 | r410 | Lorca DeportivaLorca Deporti | 0 - 1 | CordobaCordoba |
| 17 Jan 21 | r410 | MarbellaMarbella | 0 - 0 | Algeciras CFAlgeciras CF |
| 17 Jan 21 | r410 | YeclanoYeclano | 1 - 1 | Linares DeportivoLinares Depor |
| 17 Jan 21 | r410 | Betis DeportivoBetis Deporti | 1 - 0 | El EjidoEl Ejido |
| |
| 23 Jan 21 | r411 | CD MarinoCD Marino | 0 - 3 | MarbellaMarbella |
| 23 Jan 21 | r411 | MurciaMurcia | 0 - 2 | Betis DeportivoBetis Deporti |
| 24 Jan 21 | r411 | Sevilla AtleticoSevilla Atlet | 2 - 0 | Recreativo GranadaRecreativo Gr |
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