| 21 Nov 20 | r45  | CordobaCordoba | 1 - 2 | Sevilla AtleticoSevilla Atlet |
| 21 Nov 20 | r45 | Betis DeportivoBetis Deporti | 1 - 1 | UCAM MurciaUCAM Murcia |
| 21 Nov 20 | r45 | MurciaMurcia | 3 - 0 | Linares DeportivoLinares Depor |
| 22 Nov 20 | r45 | Cadiz BCadiz B | 3 - 1 | CD MarinoCD Marino |
| 22 Nov 20 | r45 | Las Palmas AtléticoLas Palmas At | 2 - 1 | San Fernando CDSan Fernando |
| 22 Nov 20 | r45 | RecreativoRecreativo | 2 - 0 | LinenseLinense |
| 22 Nov 20 | r45 | Atlético SanluqueñoAtlético Sanl | 2 - 1 | MarbellaMarbella |
| 22 Nov 20 | r45 | Algeciras CFAlgeciras CF | 2 - 1 | TamaraceiteTamaraceite |
| 22 Nov 20 | r45 | Lorca DeportivaLorca Deporti | 1 - 1 | YeclanoYeclano |
| 22 Nov 20 | r45 | El EjidoEl Ejido | 0 - 1 | Recreativo GranadaRecreativo Gr |
| 01 May 21 | r45 | Recreativo GranadaRecreativo Gr | 1 - 1 | CD MarinoCD Marino |
| 02 May 21 | r45 | Lorca DeportivaLorca Deporti | 2 - 2 | Las Palmas AtléticoLas Palmas At |
| 02 May 21 | r45 | Cadiz BCadiz B | 0 - 1 | MurciaMurcia |
| 02 May 21 | r45 | YeclanoYeclano | 2 - 1 | RecreativoRecreativo |
| 02 May 21 | r45 | El EjidoEl Ejido | 2 - 0 | MarbellaMarbella |
| 02 May 21 | r45 | TamaraceiteTamaraceite | 1 - 1 | Sevilla AtleticoSevilla Atlet |
| 02 May 21 | r45 | Atlético SanluqueñoAtlético Sanl | 2 - 1 | Betis DeportivoBetis Deporti |
| 02 May 21 | r45 | LinenseLinense | 0 - 5 | CordobaCordoba |
| 02 May 21 | r45 | Algeciras CFAlgeciras CF | 0 - 0 | Linares DeportivoLinares Depor |
| 02 May 21 | r45 | San Fernando CDSan Fernando | 2 - 0 | UCAM MurciaUCAM Murcia |
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