| 25 Oct 20 | r42  | LinenseLinense | 0 - 0 | TamaraceiteTamaraceite |
| 25 Oct 20 | r42 | MarbellaMarbella | 5 - 1 | CD MarinoCD Marino |
| 25 Oct 20 | r42 | Lorca DeportivaLorca Deporti | 2 - 2 | El EjidoEl Ejido |
| 25 Oct 20 | r42 | UCAM MurciaUCAM Murcia | 1 - 0 | Linares DeportivoLinares Depor |
| 25 Oct 20 | r42 | Las Palmas AtléticoLas Palmas At | 0 - 1 | Atlético SanluqueñoAtlético Sanl |
| 25 Oct 20 | r42 | RecreativoRecreativo | 0 - 1 | Algeciras CFAlgeciras CF |
| 25 Oct 20 | r42 | San Fernando CDSan Fernando | 0 - 1 | Cadiz BCadiz B |
| 25 Oct 20 | r42 | YeclanoYeclano | 1 - 3 | CordobaCordoba |
| 18 Nov 20 | r42 | Recreativo GranadaRecreativo Gr | 2 - 2 | Sevilla AtleticoSevilla Atlet |
| 25 Nov 20 | r42 | Betis DeportivoBetis Deporti | 2 - 1 | MurciaMurcia |
| 11 Apr 21 | r42 | Lorca DeportivaLorca Deporti | 2 - 1 | CD MarinoCD Marino |
| 11 Apr 21 | r42 | YeclanoYeclano | 2 - 1 | Las Palmas AtléticoLas Palmas At |
| 11 Apr 21 | r42 | Sevilla AtleticoSevilla Atlet | 0 - 0 | TamaraceiteTamaraceite |
| 11 Apr 21 | r42 | Recreativo GranadaRecreativo Gr | 0 - 1 | MarbellaMarbella |
| 11 Apr 21 | r42 | Betis DeportivoBetis Deporti | 3 - 1 | Atlético SanluqueñoAtlético Sanl |
| 11 Apr 21 | r42 | CordobaCordoba | 1 - 2 | LinenseLinense |
| 11 Apr 21 | r42 | MurciaMurcia | 2 - 1 | Cadiz BCadiz B |
| 11 Apr 21 | r42 | Linares DeportivoLinares Depor | 1 - 0 | Algeciras CFAlgeciras CF |
| 11 Apr 21 | r42 | UCAM MurciaUCAM Murcia | 3 - 1 | San Fernando CDSan Fernando |
| 11 Apr 21 | r42 | El EjidoEl Ejido | 2 - 0 | RecreativoRecreativo |
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