| 18 Oct 20 | r41  | Sevilla AtleticoSevilla Atlet | 0 - 1 | UCAM MurciaUCAM Murcia |
| 18 Oct 20 | r41 | Cadiz BCadiz B | 2 - 0 | Las Palmas AtléticoLas Palmas At |
| 18 Oct 20 | r41 | TamaraceiteTamaraceite | 0 - 0 | San Fernando CDSan Fernando |
| 18 Oct 20 | r41 | CD MarinoCD Marino | 0 - 1 | LinenseLinense |
| 18 Oct 20 | r41 | Atlético SanluqueñoAtlético Sanl | 1 - 1 | RecreativoRecreativo |
| 18 Oct 20 | r41 | Linares DeportivoLinares Depor | 0 - 0 | YeclanoYeclano |
| 18 Oct 20 | r41 | Algeciras CFAlgeciras CF | 0 - 0 | MarbellaMarbella |
| 18 Oct 20 | r41 | El EjidoEl Ejido | 3 - 0 | Betis DeportivoBetis Deporti |
| 18 Oct 20 | r41 | CordobaCordoba | 1 - 0 | Lorca DeportivaLorca Deporti |
| 15 Nov 20 | r41 | MurciaMurcia | 1 - 2 | Recreativo GranadaRecreativo Gr |
| 03 Apr 21 | r41 | Las Palmas AtléticoLas Palmas At | 3 - 1 | Lorca DeportivaLorca Deporti |
| 03 Apr 21 | r41 | CD MarinoCD Marino | 1 - 2 | Recreativo GranadaRecreativo Gr |
| 04 Apr 21 | r41 | Algeciras CFAlgeciras CF | 1 - 0 | Betis DeportivoBetis Deporti |
| 04 Apr 21 | r41 | Cadiz BCadiz B | 1 - 4 | Sevilla AtleticoSevilla Atlet |
| 04 Apr 21 | r41 | RecreativoRecreativo | 0 - 1 | YeclanoYeclano |
| 04 Apr 21 | r41 | TamaraceiteTamaraceite | 0 - 1 | CordobaCordoba |
| 04 Apr 21 | r41 | LinenseLinense | 1 - 0 | MurciaMurcia |
| 04 Apr 21 | r41 | Atlético SanluqueñoAtlético Sanl | 0 - 1 | UCAM MurciaUCAM Murcia |
| 04 Apr 21 | r41 | MarbellaMarbella | 1 - 0 | El EjidoEl Ejido |
| 14 Apr 21 | r41 | San Fernando CDSan Fernando | 0 - 1 | Linares DeportivoLinares Depor |
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