| 18 Oct 20 | r41  | Sevilla AtleticoSevilla Atlet | 0 - 1 | UCAM MurciaUCAM Murcia |
| 18 Oct 20 | r41 | Cadiz BCadiz B | 2 - 0 | Las Palmas AtléticoLas Palmas At |
| 18 Oct 20 | r41 | TamaraceiteTamaraceite | 0 - 0 | San Fernando CDSan Fernando |
| 18 Oct 20 | r41 | CD MarinoCD Marino | 0 - 1 | LinenseLinense |
| 18 Oct 20 | r41 | Atlético SanluqueñoAtlético Sanl | 1 - 1 | RecreativoRecreativo |
| 18 Oct 20 | r41 | Linares DeportivoLinares Depor | 0 - 0 | YeclanoYeclano |
| 18 Oct 20 | r41 | Algeciras CFAlgeciras CF | 0 - 0 | MarbellaMarbella |
| 18 Oct 20 | r41 | El EjidoEl Ejido | 3 - 0 | Betis DeportivoBetis Deporti |
| 18 Oct 20 | r41 | CordobaCordoba | 1 - 0 | Lorca DeportivaLorca Deporti |
| |
| 25 Oct 20 | r42 | LinenseLinense | 0 - 0 | TamaraceiteTamaraceite |
| 25 Oct 20 | r42 | MarbellaMarbella | 5 - 1 | CD MarinoCD Marino |
| 25 Oct 20 | r42 | Lorca DeportivaLorca Deporti | 2 - 2 | El EjidoEl Ejido |
| 25 Oct 20 | r42 | UCAM MurciaUCAM Murcia | 1 - 0 | Linares DeportivoLinares Depor |
| 25 Oct 20 | r42 | Las Palmas AtléticoLas Palmas At | 0 - 1 | Atlético SanluqueñoAtlético Sanl |
| 25 Oct 20 | r42 | RecreativoRecreativo | 0 - 1 | Algeciras CFAlgeciras CF |
| 25 Oct 20 | r42 | San Fernando CDSan Fernando | 0 - 1 | Cadiz BCadiz B |
| 25 Oct 20 | r42 | YeclanoYeclano | 1 - 3 | CordobaCordoba |
| |
| 01 Nov 20 | r43 | RecreativoRecreativo | 2 - 0 | Las Palmas AtléticoLas Palmas At |
| 01 Nov 20 | r43 | Cadiz BCadiz B | 1 - 2 | LinenseLinense |
| 01 Nov 20 | r43 | TamaraceiteTamaraceite | 3 - 1 | MarbellaMarbella |
| 01 Nov 20 | r43 | Algeciras CFAlgeciras CF | 2 - 1 | CD MarinoCD Marino |
| 01 Nov 20 | r43 | CordobaCordoba | 0 - 0 | UCAM MurciaUCAM Murcia |
| 01 Nov 20 | r43 | MurciaMurcia | 1 - 1 | Sevilla AtleticoSevilla Atlet |
| 01 Nov 20 | r43 | El EjidoEl Ejido | 2 - 0 | YeclanoYeclano |
| 01 Nov 20 | r43 | Atlético SanluqueñoAtlético Sanl | 1 - 3 | San Fernando CDSan Fernando |
| 01 Nov 20 | r43 | Betis DeportivoBetis Deporti | 0 - 0 | Lorca DeportivaLorca Deporti |
| |
| 08 Nov 20 | r44 | LinenseLinense | 0 - 0 | Atlético SanluqueñoAtlético Sanl |
| 08 Nov 20 | r44 | Recreativo GranadaRecreativo Gr | 1 - 1 | CordobaCordoba |
| 08 Nov 20 | r44 | CD MarinoCD Marino | 0 - 0 | TamaraceiteTamaraceite |
| 08 Nov 20 | r44 | UCAM MurciaUCAM Murcia | 2 - 1 | El EjidoEl Ejido |
| 08 Nov 20 | r44 | Las Palmas AtléticoLas Palmas At | 0 - 1 | Algeciras CFAlgeciras CF |
| 08 Nov 20 | r44 | MarbellaMarbella | 0 - 0 | Cadiz BCadiz B |
| 08 Nov 20 | r44 | Lorca DeportivaLorca Deporti | 1 - 2 | MurciaMurcia |
| 08 Nov 20 | r44 | YeclanoYeclano | 1 - 1 | Betis DeportivoBetis Deporti |
| 08 Nov 20 | r44 | Sevilla AtleticoSevilla Atlet | 1 - 4 | Linares DeportivoLinares Depor |
| |
| 15 Nov 20 | r41 | MurciaMurcia | 1 - 2 | Recreativo GranadaRecreativo Gr |
| |
| 18 Nov 20 | r42 | Recreativo GranadaRecreativo Gr | 2 - 2 | Sevilla AtleticoSevilla Atlet |
| |
| 21 Nov 20 | r45 | CordobaCordoba | 1 - 2 | Sevilla AtleticoSevilla Atlet |
| 21 Nov 20 | r45 | Betis DeportivoBetis Deporti | 1 - 1 | UCAM MurciaUCAM Murcia |
| 21 Nov 20 | r45 | MurciaMurcia | 3 - 0 | Linares DeportivoLinares Depor |
| 22 Nov 20 | r45 | Cadiz BCadiz B | 3 - 1 | CD MarinoCD Marino |
| 22 Nov 20 | r45 | Las Palmas AtléticoLas Palmas At | 2 - 1 | San Fernando CDSan Fernando |
| 22 Nov 20 | r45 | RecreativoRecreativo | 2 - 0 | LinenseLinense |
| 22 Nov 20 | r45 | Atlético SanluqueñoAtlético Sanl | 2 - 1 | MarbellaMarbella |
| 22 Nov 20 | r45 | Algeciras CFAlgeciras CF | 2 - 1 | TamaraceiteTamaraceite |
| 22 Nov 20 | r45 | Lorca DeportivaLorca Deporti | 1 - 1 | YeclanoYeclano |
| 22 Nov 20 | r45 | El EjidoEl Ejido | 0 - 1 | Recreativo GranadaRecreativo Gr |
| |
| 25 Nov 20 | r42 | Betis DeportivoBetis Deporti | 2 - 1 | MurciaMurcia |
| |
| 25 Nov 20 | r43 | Linares DeportivoLinares Depor | 1 - 0 | Recreativo GranadaRecreativo Gr |
| |
| 28 Nov 20 | r46 | San Fernando CDSan Fernando | 1 - 2 | Algeciras CFAlgeciras CF |
| 29 Nov 20 | r46 | LinenseLinense | 0 - 0 | Las Palmas AtléticoLas Palmas At |
| 29 Nov 20 | r46 | UCAM MurciaUCAM Murcia | 1 - 0 | Lorca DeportivaLorca Deporti |
| 29 Nov 20 | r46 | Recreativo GranadaRecreativo Gr | 0 - 0 | Betis DeportivoBetis Deporti |
| 29 Nov 20 | r46 | TamaraceiteTamaraceite | 1 - 0 | Cadiz BCadiz B |
| 29 Nov 20 | r46 | CD MarinoCD Marino | 0 - 1 | Atlético SanluqueñoAtlético Sanl |
| 29 Nov 20 | r46 | YeclanoYeclano | 1 - 2 | MurciaMurcia |
| 29 Nov 20 | r46 | Linares DeportivoLinares Depor | 2 - 0 | CordobaCordoba |
| 29 Nov 20 | r46 | Sevilla AtleticoSevilla Atlet | 1 - 1 | El EjidoEl Ejido |
| 29 Nov 20 | r46 | MarbellaMarbella | 2 - 0 | RecreativoRecreativo |
| |
| 05 Dec 20 | r47 | RecreativoRecreativo | 6 - 0 | CD MarinoCD Marino |
| 05 Dec 20 | r47 | San Fernando CDSan Fernando | 2 - 1 | LinenseLinense |
| 06 Dec 20 | r47 | Las Palmas AtléticoLas Palmas At | 1 - 1 | MarbellaMarbella |
| 06 Dec 20 | r47 | Atlético SanluqueñoAtlético Sanl | 0 - 0 | TamaraceiteTamaraceite |
| 06 Dec 20 | r47 | Lorca DeportivaLorca Deporti | 2 - 2 | Recreativo GranadaRecreativo Gr |
| 06 Dec 20 | r47 | Betis DeportivoBetis Deporti | 3 - 0 | Sevilla AtleticoSevilla Atlet |
| 06 Dec 20 | r47 | El EjidoEl Ejido | 0 - 2 | Linares DeportivoLinares Depor |
| 06 Dec 20 | r47 | YeclanoYeclano | 0 - 2 | UCAM MurciaUCAM Murcia |
| 06 Dec 20 | r47 | MurciaMurcia | 0 - 1 | CordobaCordoba |
| |
| 09 Dec 20 | r44 | San Fernando CDSan Fernando | 1 - 0 | RecreativoRecreativo |
| |
| 12 Dec 20 | r48 | CD MarinoCD Marino | 0 - 0 | Las Palmas AtléticoLas Palmas At |
| 12 Dec 20 | r48 | Linares DeportivoLinares Depor | 1 - 1 | Betis DeportivoBetis Deporti |
| 13 Dec 20 | r48 | Sevilla AtleticoSevilla Atlet | 4 - 0 | Lorca DeportivaLorca Deporti |
| 13 Dec 20 | r48 | Recreativo GranadaRecreativo Gr | 2 - 0 | YeclanoYeclano |
| 13 Dec 20 | r48 | MurciaMurcia | 2 - 1 | UCAM MurciaUCAM Murcia |
| 13 Dec 20 | r48 | CordobaCordoba | 4 - 0 | El EjidoEl Ejido |
| 13 Dec 20 | r48 | MarbellaMarbella | 1 - 2 | San Fernando CDSan Fernando |
| |
| 19 Dec 20 | r47 | Algeciras CFAlgeciras CF | 2 - 0 | Cadiz BCadiz B |
| |
| 20 Dec 20 | r48 | TamaraceiteTamaraceite | 2 - 1 | RecreativoRecreativo |
| 03 Jan 21 | r48 | Algeciras CFAlgeciras CF | 1 - 1 | LinenseLinense |
| 03 Jan 21 | r48 | Cadiz BCadiz B | 1 - 2 | Atlético SanluqueñoAtlético Sanl |
| |
| 09 Jan 21 | r49 | UCAM MurciaUCAM Murcia | 2 - 1 | Recreativo GranadaRecreativo Gr |
| 10 Jan 21 | r49 | Atlético SanluqueñoAtlético Sanl | 2 - 0 | Algeciras CFAlgeciras CF |
| 10 Jan 21 | r49 | San Fernando CDSan Fernando | 2 - 3 | CD MarinoCD Marino |
| 10 Jan 21 | r49 | Lorca DeportivaLorca Deporti | 0 - 3 | Linares DeportivoLinares Depor |
| 10 Jan 21 | r49 | Las Palmas AtléticoLas Palmas At | 1 - 1 | TamaraceiteTamaraceite |
| 10 Jan 21 | r49 | Betis DeportivoBetis Deporti | 0 - 0 | CordobaCordoba |
| 10 Jan 21 | r49 | YeclanoYeclano | 3 - 1 | Sevilla AtleticoSevilla Atlet |
| 10 Jan 21 | r49 | El EjidoEl Ejido | 1 - 1 | MurciaMurcia |
| |
| 16 Jan 21 | r410 | LinenseLinense | 1 - 0 | CD MarinoCD Marino |
| 17 Jan 21 | r410 | RecreativoRecreativo | 1 - 0 | Atlético SanluqueñoAtlético Sanl |
| 17 Jan 21 | r410 | San Fernando CDSan Fernando | 1 - 0 | TamaraceiteTamaraceite |
| 17 Jan 21 | r410 | UCAM MurciaUCAM Murcia | 2 - 3 | Sevilla AtleticoSevilla Atlet |
| 17 Jan 21 | r410 | Recreativo GranadaRecreativo Gr | 0 - 1 | MurciaMurcia |
| 17 Jan 21 | r410 | Lorca DeportivaLorca Deporti | 0 - 1 | CordobaCordoba |
| 17 Jan 21 | r410 | MarbellaMarbella | 0 - 0 | Algeciras CFAlgeciras CF |
| 17 Jan 21 | r410 | YeclanoYeclano | 1 - 1 | Linares DeportivoLinares Depor |
| 17 Jan 21 | r410 | Betis DeportivoBetis Deporti | 1 - 0 | El EjidoEl Ejido |
| |
| 23 Jan 21 | r411 | CD MarinoCD Marino | 0 - 3 | MarbellaMarbella |
| 23 Jan 21 | r411 | MurciaMurcia | 0 - 2 | Betis DeportivoBetis Deporti |
| 24 Jan 21 | r411 | Sevilla AtleticoSevilla Atlet | 2 - 0 | Recreativo GranadaRecreativo Gr |
| 24 Jan 21 | r411 | Algeciras CFAlgeciras CF | 3 - 1 | RecreativoRecreativo |
| 24 Jan 21 | r411 | Atlético SanluqueñoAtlético Sanl | 0 - 1 | Las Palmas AtléticoLas Palmas At |
| 24 Jan 21 | r411 | El EjidoEl Ejido | 1 - 1 | Lorca DeportivaLorca Deporti |
| 24 Jan 21 | r411 | TamaraceiteTamaraceite | 1 - 0 | LinenseLinense |
| 24 Jan 21 | r411 | Cadiz BCadiz B | 1 - 2 | San Fernando CDSan Fernando |
| 24 Jan 21 | r411 | CordobaCordoba | 1 - 2 | YeclanoYeclano |
| 24 Jan 21 | r411 | Linares DeportivoLinares Depor | 1 - 0 | UCAM MurciaUCAM Murcia |
| |
| 30 Jan 21 | r412 | CD MarinoCD Marino | 1 - 1 | Algeciras CFAlgeciras CF |
| 31 Jan 21 | r412 | Sevilla AtleticoSevilla Atlet | 1 - 1 | MurciaMurcia |
| 31 Jan 21 | r412 | MarbellaMarbella | 1 - 3 | TamaraceiteTamaraceite |
| 31 Jan 21 | r412 | Recreativo GranadaRecreativo Gr | 0 - 1 | Linares DeportivoLinares Depor |
| 31 Jan 21 | r412 | LinenseLinense | 1 - 0 | Cadiz BCadiz B |
| 31 Jan 21 | r412 | San Fernando CDSan Fernando | 2 - 0 | Atlético SanluqueñoAtlético Sanl |
| 31 Jan 21 | r412 | UCAM MurciaUCAM Murcia | 1 - 1 | CordobaCordoba |
| 31 Jan 21 | r412 | Lorca DeportivaLorca Deporti | 2 - 3 | Betis DeportivoBetis Deporti |
| 31 Jan 21 | r412 | YeclanoYeclano | 0 - 2 | El EjidoEl Ejido |
| |
| 06 Feb 21 | r413 | Cadiz BCadiz B | 1 - 0 | MarbellaMarbella |
| 07 Feb 21 | r413 | Atlético SanluqueñoAtlético Sanl | 0 - 4 | LinenseLinense |
| 07 Feb 21 | r413 | El EjidoEl Ejido | 1 - 1 | UCAM MurciaUCAM Murcia |
| 07 Feb 21 | r413 | TamaraceiteTamaraceite | 2 - 1 | CD MarinoCD Marino |
| 07 Feb 21 | r413 | MurciaMurcia | 1 - 1 | Lorca DeportivaLorca Deporti |
| 07 Feb 21 | r413 | Linares DeportivoLinares Depor | 0 - 3 | Sevilla AtleticoSevilla Atlet |
| 07 Feb 21 | r413 | CordobaCordoba | 1 - 1 | Recreativo GranadaRecreativo Gr |
| |
| 10 Feb 21 | r49 | LinenseLinense | 2 - 1 | MarbellaMarbella |
| |
| 13 Feb 21 | r414 | CD MarinoCD Marino | 0 - 0 | Cadiz BCadiz B |
| 14 Feb 21 | r414 | Sevilla AtleticoSevilla Atlet | 1 - 0 | CordobaCordoba |
| 14 Feb 21 | r414 | Recreativo GranadaRecreativo Gr | 0 - 1 | El EjidoEl Ejido |
| 14 Feb 21 | r414 | San Fernando CDSan Fernando | 0 - 0 | Las Palmas AtléticoLas Palmas At |
| 14 Feb 21 | r414 | UCAM MurciaUCAM Murcia | 1 - 1 | Betis DeportivoBetis Deporti |
| 14 Feb 21 | r414 | TamaraceiteTamaraceite | 1 - 1 | Algeciras CFAlgeciras CF |
| 14 Feb 21 | r414 | LinenseLinense | 1 - 1 | RecreativoRecreativo |
| 14 Feb 21 | r414 | Linares DeportivoLinares Depor | 2 - 0 | MurciaMurcia |
| 14 Feb 21 | r414 | MarbellaMarbella | 0 - 1 | Atlético SanluqueñoAtlético Sanl |
| |
| 17 Feb 21 | r49 | RecreativoRecreativo | 2 - 3 | Cadiz BCadiz B |
| |
| 20 Feb 21 | r415 | Lorca DeportivaLorca Deporti | 1 - 2 | UCAM MurciaUCAM Murcia |
| 20 Feb 21 | r415 | Betis DeportivoBetis Deporti | 0 - 2 | Recreativo GranadaRecreativo Gr |
| 21 Feb 21 | r415 | Algeciras CFAlgeciras CF | 0 - 3 | San Fernando CDSan Fernando |
| 21 Feb 21 | r415 | RecreativoRecreativo | 1 - 3 | MarbellaMarbella |
| 21 Feb 21 | r415 | Cadiz BCadiz B | 2 - 2 | TamaraceiteTamaraceite |
| 21 Feb 21 | r415 | Atlético SanluqueñoAtlético Sanl | 2 - 0 | CD MarinoCD Marino |
| 21 Feb 21 | r415 | Las Palmas AtléticoLas Palmas At | 1 - 1 | LinenseLinense |
| 21 Feb 21 | r415 | MurciaMurcia | 1 - 0 | YeclanoYeclano |
| 21 Feb 21 | r415 | El EjidoEl Ejido | 0 - 0 | Sevilla AtleticoSevilla Atlet |
| 21 Feb 21 | r415 | CordobaCordoba | 2 - 1 | Linares DeportivoLinares Depor |
| |
| 27 Feb 21 | r413 | Betis DeportivoBetis Deporti | 2 - 2 | YeclanoYeclano |
| |
| 28 Feb 21 | r410 | Las Palmas AtléticoLas Palmas At | 0 - 0 | Cadiz BCadiz B |
| |
| 28 Feb 21 | r413 | RecreativoRecreativo | 3 - 1 | San Fernando CDSan Fernando |
| |
| 03 Mar 21 | r412 | Las Palmas AtléticoLas Palmas At | 3 - 3 | RecreativoRecreativo |
| |
| 03 Mar 21 | r414 | YeclanoYeclano | 1 - 2 | Lorca DeportivaLorca Deporti |
| |
| 06 Mar 21 | r416 | Cadiz BCadiz B | 2 - 0 | Algeciras CFAlgeciras CF |
| 06 Mar 21 | r416 | UCAM MurciaUCAM Murcia | 1 - 0 | YeclanoYeclano |
| 06 Mar 21 | r416 | CD MarinoCD Marino | 2 - 1 | RecreativoRecreativo |
| 07 Mar 21 | r416 | Sevilla AtleticoSevilla Atlet | 0 - 0 | Betis DeportivoBetis Deporti |
| 07 Mar 21 | r416 | LinenseLinense | 0 - 0 | San Fernando CDSan Fernando |
| 07 Mar 21 | r416 | MarbellaMarbella | 0 - 0 | Las Palmas AtléticoLas Palmas At |
| 07 Mar 21 | r416 | Recreativo GranadaRecreativo Gr | 3 - 2 | Lorca DeportivaLorca Deporti |
| 07 Mar 21 | r416 | TamaraceiteTamaraceite | 0 - 0 | Atlético SanluqueñoAtlético Sanl |
| 07 Mar 21 | r416 | Linares DeportivoLinares Depor | 2 - 0 | El EjidoEl Ejido |
| 07 Mar 21 | r416 | CordobaCordoba | 2 - 2 | MurciaMurcia |
| |
| 10 Mar 21 | r413 | Algeciras CFAlgeciras CF | 2 - 0 | Las Palmas AtléticoLas Palmas At |
| |
| 14 Mar 21 | r417 | RecreativoRecreativo | 2 - 2 | TamaraceiteTamaraceite |
| 14 Mar 21 | r417 | Las Palmas AtléticoLas Palmas At | 2 - 1 | CD MarinoCD Marino |
| 14 Mar 21 | r417 | LinenseLinense | 0 - 1 | Algeciras CFAlgeciras CF |
| 14 Mar 21 | r417 | San Fernando CDSan Fernando | 0 - 0 | MarbellaMarbella |
| 14 Mar 21 | r417 | UCAM MurciaUCAM Murcia | 1 - 1 | MurciaMurcia |
| 14 Mar 21 | r417 | YeclanoYeclano | 0 - 2 | Recreativo GranadaRecreativo Gr |
| 14 Mar 21 | r417 | Lorca DeportivaLorca Deporti | 0 - 4 | Sevilla AtleticoSevilla Atlet |
| 14 Mar 21 | r417 | Betis DeportivoBetis Deporti | 4 - 0 | Linares DeportivoLinares Depor |
| 14 Mar 21 | r417 | El EjidoEl Ejido | 0 - 1 | CordobaCordoba |
| 14 Mar 21 | r417 | Atlético SanluqueñoAtlético Sanl | 2 - 1 | Cadiz BCadiz B |
| |
| 21 Mar 21 | r418 | MarbellaMarbella | 1 - 2 | LinenseLinense |
| 21 Mar 21 | r418 | TamaraceiteTamaraceite | 0 - 2 | Las Palmas AtléticoLas Palmas At |
| 21 Mar 21 | r418 | Cadiz BCadiz B | 2 - 2 | RecreativoRecreativo |
| 21 Mar 21 | r418 | Algeciras CFAlgeciras CF | 2 - 3 | Atlético SanluqueñoAtlético Sanl |
| 21 Mar 21 | r418 | Recreativo GranadaRecreativo Gr | 1 - 2 | UCAM MurciaUCAM Murcia |
| 21 Mar 21 | r418 | Sevilla AtleticoSevilla Atlet | 1 - 0 | YeclanoYeclano |
| 21 Mar 21 | r418 | CD MarinoCD Marino | 0 - 1 | San Fernando CDSan Fernando |
| 21 Mar 21 | r418 | Linares DeportivoLinares Depor | 1 - 0 | Lorca DeportivaLorca Deporti |
| 21 Mar 21 | r418 | CordobaCordoba | 1 - 2 | Betis DeportivoBetis Deporti |
| 21 Mar 21 | r418 | MurciaMurcia | 2 - 2 | El EjidoEl Ejido |
| |
| 03 Apr 21 | r41 | Las Palmas AtléticoLas Palmas At | 3 - 1 | Lorca DeportivaLorca Deporti |
| 03 Apr 21 | r41 | CD MarinoCD Marino | 1 - 2 | Recreativo GranadaRecreativo Gr |
| 04 Apr 21 | r41 | Algeciras CFAlgeciras CF | 1 - 0 | Betis DeportivoBetis Deporti |
| 04 Apr 21 | r41 | Cadiz BCadiz B | 1 - 4 | Sevilla AtleticoSevilla Atlet |
| 04 Apr 21 | r41 | RecreativoRecreativo | 0 - 1 | YeclanoYeclano |
| 04 Apr 21 | r41 | TamaraceiteTamaraceite | 0 - 1 | CordobaCordoba |
| 04 Apr 21 | r41 | LinenseLinense | 1 - 0 | MurciaMurcia |
| 04 Apr 21 | r41 | Atlético SanluqueñoAtlético Sanl | 0 - 1 | UCAM MurciaUCAM Murcia |
| 04 Apr 21 | r41 | MarbellaMarbella | 1 - 0 | El EjidoEl Ejido |
| |
| 11 Apr 21 | r42 | Lorca DeportivaLorca Deporti | 2 - 1 | CD MarinoCD Marino |
| 11 Apr 21 | r42 | YeclanoYeclano | 2 - 1 | Las Palmas AtléticoLas Palmas At |
| 11 Apr 21 | r42 | Sevilla AtleticoSevilla Atlet | 0 - 0 | TamaraceiteTamaraceite |
| 11 Apr 21 | r42 | Recreativo GranadaRecreativo Gr | 0 - 1 | MarbellaMarbella |
| 11 Apr 21 | r42 | Betis DeportivoBetis Deporti | 3 - 1 | Atlético SanluqueñoAtlético Sanl |
| 11 Apr 21 | r42 | CordobaCordoba | 1 - 2 | LinenseLinense |
| 11 Apr 21 | r42 | MurciaMurcia | 2 - 1 | Cadiz BCadiz B |
| 11 Apr 21 | r42 | Linares DeportivoLinares Depor | 1 - 0 | Algeciras CFAlgeciras CF |
| 11 Apr 21 | r42 | UCAM MurciaUCAM Murcia | 3 - 1 | San Fernando CDSan Fernando |
| 11 Apr 21 | r42 | El EjidoEl Ejido | 2 - 0 | RecreativoRecreativo |
| |
| 14 Apr 21 | r41 | San Fernando CDSan Fernando | 0 - 1 | Linares DeportivoLinares Depor |
| |
| 17 Apr 21 | r43 | Las Palmas AtléticoLas Palmas At | 0 - 1 | El EjidoEl Ejido |
| 17 Apr 21 | r43 | CD MarinoCD Marino | 1 - 2 | YeclanoYeclano |
| 18 Apr 21 | r43 | Algeciras CFAlgeciras CF | 1 - 1 | UCAM MurciaUCAM Murcia |
| 18 Apr 21 | r43 | Cadiz BCadiz B | 2 - 0 | CordobaCordoba |
| 18 Apr 21 | r43 | TamaraceiteTamaraceite | 1 - 0 | MurciaMurcia |
| 18 Apr 21 | r43 | LinenseLinense | 3 - 1 | Sevilla AtleticoSevilla Atlet |
| 18 Apr 21 | r43 | Atlético SanluqueñoAtlético Sanl | 0 - 2 | Linares DeportivoLinares Depor |
| 18 Apr 21 | r43 | San Fernando CDSan Fernando | 2 - 1 | Betis DeportivoBetis Deporti |
| 18 Apr 21 | r43 | RecreativoRecreativo | 0 - 1 | Recreativo GranadaRecreativo Gr |
| 18 Apr 21 | r43 | MarbellaMarbella | 2 - 1 | Lorca DeportivaLorca Deporti |
| |
| 25 Apr 21 | r44 | El EjidoEl Ejido | 4 - 0 | CD MarinoCD Marino |
| 25 Apr 21 | r44 | Recreativo GranadaRecreativo Gr | 0 - 1 | Las Palmas AtléticoLas Palmas At |
| 25 Apr 21 | r44 | Sevilla AtleticoSevilla Atlet | 1 - 2 | Cadiz BCadiz B |
| 25 Apr 21 | r44 | YeclanoYeclano | 3 - 1 | MarbellaMarbella |
| 25 Apr 21 | r44 | CordobaCordoba | 1 - 1 | TamaraceiteTamaraceite |
| 25 Apr 21 | r44 | Lorca DeportivaLorca Deporti | 2 - 1 | RecreativoRecreativo |
| 25 Apr 21 | r44 | Betis DeportivoBetis Deporti | 3 - 0 | Algeciras CFAlgeciras CF |
| 25 Apr 21 | r44 | Linares DeportivoLinares Depor | 1 - 1 | San Fernando CDSan Fernando |
| 25 Apr 21 | r44 | UCAM MurciaUCAM Murcia | 3 - 2 | Atlético SanluqueñoAtlético Sanl |
| 25 Apr 21 | r44 | MurciaMurcia | 0 - 0 | LinenseLinense |
| |
| 01 May 21 | r45 | Recreativo GranadaRecreativo Gr | 1 - 1 | CD MarinoCD Marino |
| 02 May 21 | r45 | Lorca DeportivaLorca Deporti | 2 - 2 | Las Palmas AtléticoLas Palmas At |
| 02 May 21 | r45 | Cadiz BCadiz B | 0 - 1 | MurciaMurcia |
| 02 May 21 | r45 | YeclanoYeclano | 2 - 1 | RecreativoRecreativo |
| 02 May 21 | r45 | El EjidoEl Ejido | 2 - 0 | MarbellaMarbella |
| 02 May 21 | r45 | TamaraceiteTamaraceite | 1 - 1 | Sevilla AtleticoSevilla Atlet |
| 02 May 21 | r45 | Atlético SanluqueñoAtlético Sanl | 2 - 1 | Betis DeportivoBetis Deporti |
| 02 May 21 | r45 | LinenseLinense | 0 - 5 | CordobaCordoba |
| 02 May 21 | r45 | Algeciras CFAlgeciras CF | 0 - 0 | Linares DeportivoLinares Depor |
| 02 May 21 | r45 | San Fernando CDSan Fernando | 2 - 0 | UCAM MurciaUCAM Murcia |
| |
| 08 May 21 | r46 | CD MarinoCD Marino | 0 - 1 | Lorca DeportivaLorca Deporti |
| 09 May 21 | r46 | Linares DeportivoLinares Depor | 1 - 0 | Atlético SanluqueñoAtlético Sanl |
| 09 May 21 | r46 | UCAM MurciaUCAM Murcia | 1 - 2 | Algeciras CFAlgeciras CF |
| 09 May 21 | r46 | Betis DeportivoBetis Deporti | 2 - 1 | San Fernando CDSan Fernando |
| 09 May 21 | r46 | CordobaCordoba | 2 - 1 | Cadiz BCadiz B |
| 09 May 21 | r46 | Sevilla AtleticoSevilla Atlet | 3 - 1 | LinenseLinense |
| 09 May 21 | r46 | MurciaMurcia | 2 - 1 | TamaraceiteTamaraceite |
| 09 May 21 | r46 | Las Palmas AtléticoLas Palmas At | 4 - 2 | YeclanoYeclano |
| 09 May 21 | r46 | RecreativoRecreativo | 1 - 2 | El EjidoEl Ejido |
| 09 May 21 | r46 | MarbellaMarbella | 0 - 0 | Recreativo GranadaRecreativo Gr |
| |
| 16 May 21 | r47 | El EjidoEl Ejido | 1 - 3 | Las Palmas AtléticoLas Palmas At |
| 16 May 21 | r47 | YeclanoYeclano | 4 - 2 | CD MarinoCD Marino |
| 16 May 21 | r47 | Recreativo GranadaRecreativo Gr | 1 - 0 | RecreativoRecreativo |
| 16 May 21 | r47 | Lorca DeportivaLorca Deporti | 2 - 3 | MarbellaMarbella |
| |
| 23 May 21 | r48 | RecreativoRecreativo | 4 - 0 | Lorca DeportivaLorca Deporti |
| 23 May 21 | r48 | MarbellaMarbella | 3 - 0 | YeclanoYeclano |
| 23 May 21 | r48 | CD MarinoCD Marino | 1 - 1 | El EjidoEl Ejido |
| 23 May 21 | r48 | Las Palmas AtléticoLas Palmas At | 0 - 0 | Recreativo GranadaRecreativo Gr |
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