| 05 May 26 | r04      | Deportivo RiestraDeportivo Rie | 0 - 3 | GrêmioGrêmio |
| 05 May 26 | r04 | Juventud Las PiedrasJuventud Las | 2 - 2 | Atlético MineiroAtlético Mine |
| 05 May 26 | r04 | Independiente PetroleroIndependiente | 2 - 3 | CaracasCaracas |
| 06 May 26 | r04 | Academia Puerto CabelloAcademia Puer | 3 - 0 | CiencianoCienciano |
| 06 May 26 | r04 | RecoletaRecoleta | 1 - 1 | SantosSantos |
| 06 May 26 | r04 | Deportivo CuencaDeportivo Cue | 0 - 0 | San LorenzoSan Lorenzo |
| 06 May 26 | r04 | Audax ItalianoAudax Italian | 1 - 2 | Vasco da GamaVasco da Gama |
| 06 May 26 | r04 | Montevideo City TorqueMontevideo Ci | 1 - 0 | PalestinoPalestino |
| 07 May 26 | r04 | MacaráMacará | 2 - 2 | TigreTigre |
| 07 May 26 | r04 | Barracas CentralBarracas Cent | 1 - 2 | Club OlimpiaClub Olimpia |
| 07 May 26 | r04 | BotafogoBotafogo | 2 - 1 | Racing ClubRacing Club |
| 07 May 26 | r04 | Alianza AtléticoAlianza Atlét | 0 - 2 | América de CaliAmérica de Ca |
| 07 May 26 | r04 | O'HigginsO'Higgins | 0 - 0 | São PauloSão Paulo |
| 07 May 26 | r04 | Boston RiverBoston River | 2 - 4 | MillonariosMillonarios |
| 08 May 26 | r04 | CaraboboCarabobo | 1 - 2 | River PlateRiver Plate |
| 08 May 26 | r04 | BloomingBlooming | 0 - 6 | BragantinoBragantino |
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