| 03 Mar 26 | r01        | Independiente PetroleroIndependiente | 0 - 0 | GuabiráGuabirá |
| 03 Mar 26 | r01        | Montevideo City TorqueMontevideo Ci | 1 - 0 | Defensor SportingDefensor Spor |
| 04 Mar 26 | r01        | CobresalCobresal | 1 - 1 | Audax ItalianoAudax Italian |
| 04 Mar 26 | r01        | Academia Puerto CabelloAcademia Puer | 0 - 0 | MonagasMonagas |
| 04 Mar 26 | r01        | Alianza AtléticoAlianza Atlét | 2 - 0 | Deportivo GarcilasoDeportivo Gar |
| 04 Mar 26 | r01        | BloomingBlooming | 3 - 0 | San Antonio Bulo BuloSan Antonio B |
| 04 Mar 26 | r01        | CaracasCaracas | 0 - 0 | MetropolitanosMetropolitano |
| 05 Mar 26 | r01        | Atlético NacionalAtlético Naci | 1 - 3 | MillonariosMillonarios |
| 05 Mar 26 | r01        | Sportivo TrinidenseSportivo Trin | 0 - 1 | Club OlimpiaClub Olimpia |
| 05 Mar 26 | r01        | Universidad de ChileUniversidad d | 1 - 2 | PalestinoPalestino |
| 05 Mar 26 | r01        | Deportivo CuencaDeportivo Cue | 3 - 0 | Libertad FCLibertad FC |
| 05 Mar 26 | r01        | Boston RiverBoston River | 1 - 0 | Racing MontevideoRacing Montev |
| 05 Mar 26 | r01        | Club NacionalClub Nacional | 1 - 1 | RecoletaRecoleta |
| 06 Mar 26 | r01        | América de CaliAmérica de Ca | 2 - 1 | Atlético BucaramangaAtlético Buca |
| 06 Mar 26 | r01        | CiencianoCienciano | 1 - 1 | MelgarMelgar |
| 06 Mar 26 | r01        | OrenseOrense | 0 - 1 | MacaráMacará |
| 07 Apr 26 | r01        | Barracas CentralBarracas Cent | 0 - 0 | Vasco da GamaVasco da Gama |
| 07 Apr 26 | r01        | Independiente PetroleroIndependiente | 1 - 3 | Racing ClubRacing Club |
| 08 Apr 26 | r01        | O'HigginsO'Higgins | 2 - 0 | MillonariosMillonarios |
| 08 Apr 26 | r01        | Boston RiverBoston River | 0 - 1 | São PauloSão Paulo |
| 08 Apr 26 | r01        | Alianza AtléticoAlianza Atlét | 1 - 1 | TigreTigre |
| 08 Apr 26 | r01        | Deportivo RiestraDeportivo Rie | 0 - 0 | PalestinoPalestino |
| 08 Apr 26 | r01        | Deportivo CuencaDeportivo Cue | 1 - 0 | SantosSantos |
| 08 Apr 26 | r01        | RecoletaRecoleta | 1 - 1 | San LorenzoSan Lorenzo |
| 09 Apr 26 | r01        | Audax ItalianoAudax Italian | 0 - 2 | Club OlimpiaClub Olimpia |
| 09 Apr 26 | r01        | Montevideo City TorqueMontevideo Ci | 1 - 0 | GrêmioGrêmio |
| 09 Apr 26 | r01        | BloomingBlooming | 1 - 1 | River PlateRiver Plate |
| 09 Apr 26 | r01        | Academia Puerto CabelloAcademia Puer | 2 - 1 | Atlético MineiroAtlético Mine |
| 09 Apr 26 | r01        | BotafogoBotafogo | 1 - 1 | CaracasCaracas |
| 09 Apr 26 | r01        | Juventud Las PiedrasJuventud Las | 1 - 1 | CiencianoCienciano |
| 10 Apr 26 | r01        | MacaráMacará | 1 - 1 | América de CaliAmérica de Ca |
| 10 Apr 26 | r01        | CaraboboCarabobo | 1 - 0 | BragantinoBragantino |