| 05 Mar 25 | Qualifier     | Universitario de VintoUniversitario | 0 - 1 | Nacional PotosíNacional Poto |
| 05 Mar 25 | Qualifier | Universidad CatólicaUniversidad C | 1 - 1 | PalestinoPalestino |
| 05 Mar 25 | Qualifier | Sportivo LuqueñoSportivo Luqu | 2 - 0 | Sportivo AmelianoSportivo Amel |
| 05 Mar 25 | Qualifier  | Asociación Deportiva TarmAsociación De | 1 - 1 | CiencianoCienciano |
| 05 Mar 25 | Qualifier | Academia Puerto CabelloAcademia Puer | 3 - 0 | MetropolitanosMetropolitano |
| 05 Mar 25 | Qualifier | Unión EspañolaUnión Español | 2 - 2 | Everton de Viña del MarEverton de Vi |
| 05 Mar 25 | Qualifier | Racing MontevideoRacing Montev | 0 - 0 | Montevideo WanderersMontevideo Wa |
| 05 Mar 25 | Qualifier | AuroraAurora | 0 - 1 | GV San JoséGV San José |
| 06 Mar 25 | Qualifier | Once CaldasOnce Caldas | 1 - 0 | MillonariosMillonarios |
| 06 Mar 25 | Qualifier | Mushuc RunaMushuc Runa | 2 - 1 | OrenseOrense |
| 06 Mar 25 | Qualifier | Club GuaraníClub Guaraní | 2 - 0 | 2 de Mayo2 de Mayo |
| 06 Mar 25 | Qualifier | Cerro LargoCerro Largo | 2 - 2 | DanubioDanubio |
| 07 Mar 25 | Qualifier | Atlético JuniorAtlético Juni | 2 - 2 | América de CaliAmérica de Ca |
| 07 Mar 25 | Qualifier | Atlético GrauAtlético Grau | 0 - 0 | Cusco FCCusco FC |
| 07 Mar 25 | Qualifier | Deportivo La GuairaDeportivo La | 0 - 2 | CaracasCaracas |
| 07 Mar 25 | Qualifier | Universidad Católica del Universidad C | 0 - 0 | AucasAucas |
| |
| 01 Apr 25 | r01 | Boston RiverBoston River | 3 - 3 | Club GuaraníClub Guaraní |
| 01 Apr 25 | r01 | Nacional PotosíNacional Poto | 2 - 0 | IndependienteIndependiente |
| 01 Apr 25 | r01 | UniónUnión | 1 - 0 | CruzeiroCruzeiro |
| 01 Apr 25 | r01 | Deportes IquiqueDeportes Iqui | 1 - 2 | CaracasCaracas |
| 02 Apr 25 | r01 | Once CaldasOnce Caldas | 0 - 1 | FluminenseFluminense |
| 02 Apr 25 | r01 | CiencianoCienciano | 0 - 0 | Atlético MineiroAtlético Mine |
| 02 Apr 25 | r01 | CorinthiansCorinthians | 1 - 2 | HuracánHuracán |
| 02 Apr 25 | r01 | MelgarMelgar | 3 - 3 | Vasco da GamaVasco da Gama |
| 03 Apr 25 | r01 | VitóriaVitória | 1 - 1 | Universidad Católica del Universidad C |
| 03 Apr 25 | r01 | Racing MontevideoRacing Montev | 1 - 3 | América de CaliAmérica de Ca |
| 03 Apr 25 | r01 | Sportivo LuqueñoSportivo Luqu | 1 - 2 | GrêmioGrêmio |
| 03 Apr 25 | r01 | Atlético GrauAtlético Grau | 0 - 2 | Godoy CruzGodoy Cruz |
| 03 Apr 25 | r01 | GV San JoséGV San José | 1 - 1 | Unión EspañolaUnión Español |
| 03 Apr 25 | r01 | Academia Puerto CabelloAcademia Puer | 2 - 2 | LanúsLanús |
| 04 Apr 25 | r01 | Cerro LargoCerro Largo | 0 - 0 | Defensa y JusticiaDefensa y Jus |
| 04 Apr 25 | r01 | Mushuc RunaMushuc Runa | 3 - 2 | PalestinoPalestino |
| |
| 08 Apr 25 | r02 | IndependienteIndependiente | 2 - 1 | Boston RiverBoston River |
| 08 Apr 25 | r02 | GrêmioGrêmio | 2 - 0 | Atlético GrauAtlético Grau |
| 08 Apr 25 | r02 | CaracasCaracas | 2 - 2 | CiencianoCienciano |
| 09 Apr 25 | r02 | América de CaliAmérica de Ca | 1 - 1 | CorinthiansCorinthians |
| 09 Apr 25 | r02 | Godoy CruzGodoy Cruz | 2 - 0 | Sportivo LuqueñoSportivo Luqu |
| 09 Apr 25 | r02 | Vasco da GamaVasco da Gama | 1 - 0 | Academia Puerto CabelloAcademia Puer |
| 09 Apr 25 | r02 | HuracánHuracán | 5 - 0 | Racing MontevideoRacing Montev |
| 09 Apr 25 | r02 | PalestinoPalestino | 2 - 0 | UniónUnión |
| 10 Apr 25 | r02 | CruzeiroCruzeiro | 1 - 2 | Mushuc RunaMushuc Runa |
| 10 Apr 25 | r02 | Unión EspañolaUnión Español | 0 - 2 | Once CaldasOnce Caldas |
| 10 Apr 25 | r02 | LanúsLanús | 3 - 0 | MelgarMelgar |
| 10 Apr 25 | r02 | Defensa y JusticiaDefensa y Jus | 0 - 0 | VitóriaVitória |
| 11 Apr 25 | r02 | Club GuaraníClub Guaraní | 2 - 0 | Nacional PotosíNacional Poto |
| 11 Apr 25 | r02 | FluminenseFluminense | 5 - 0 | GV San JoséGV San José |
| 11 Apr 25 | r02 | Atlético MineiroAtlético Mine | 4 - 0 | Deportes IquiqueDeportes Iqui |
| 11 Apr 25 | r02 | Universidad Católica del Universidad C | 3 - 1 | Cerro LargoCerro Largo |
| |
| 22 Apr 25 | r03 | Club GuaraníClub Guaraní | 2 - 1 | IndependienteIndependiente |
| 22 Apr 25 | r03 | Boston RiverBoston River | 2 - 1 | Nacional PotosíNacional Poto |
| 23 Apr 25 | r03 | GV San JoséGV San José | 2 - 3 | Once CaldasOnce Caldas |
| 23 Apr 25 | r03 | Vasco da GamaVasco da Gama | 0 - 0 | LanúsLanús |
| 23 Apr 25 | r03 | MelgarMelgar | 1 - 0 | Academia Puerto CabelloAcademia Puer |
| 23 Apr 25 | r03 | HuracánHuracán | 0 - 0 | América de CaliAmérica de Ca |
| 23 Apr 25 | r03 | Unión EspañolaUnión Español | 1 - 1 | FluminenseFluminense |
| 24 Apr 25 | r03 | VitóriaVitória | 0 - 1 | Cerro LargoCerro Largo |
| 24 Apr 25 | r03 | CaracasCaracas | 1 - 1 | Atlético MineiroAtlético Mine |
| 24 Apr 25 | r03 | Atlético GrauAtlético Grau | 2 - 2 | Sportivo LuqueñoSportivo Luqu |
| 24 Apr 25 | r03 | Mushuc RunaMushuc Runa | 3 - 0 | UniónUnión |
| 24 Apr 25 | r03 | CorinthiansCorinthians | 1 - 0 | Racing MontevideoRacing Montev |
| 24 Apr 25 | r03 | Godoy CruzGodoy Cruz | 2 - 2 | GrêmioGrêmio |
| 25 Apr 25 | r03 | PalestinoPalestino | 2 - 1 | CruzeiroCruzeiro |
| 25 Apr 25 | r03 | Deportes IquiqueDeportes Iqui | 2 - 2 | CiencianoCienciano |
| 25 Apr 25 | r03 | Universidad Católica del Universidad C | 3 - 1 | Defensa y JusticiaDefensa y Jus |
| |
| 06 May 25 | r04 | Nacional PotosíNacional Poto | 2 - 2 | Club GuaraníClub Guaraní |
| 06 May 25 | r04 | VitóriaVitória | 1 - 1 | Defensa y JusticiaDefensa y Jus |
| 06 May 25 | r04 | Sportivo LuqueñoSportivo Luqu | 0 - 1 | Godoy CruzGodoy Cruz |
| 07 May 25 | r04 | Boston RiverBoston River | 1 - 5 | IndependienteIndependiente |
| 07 May 25 | r04 | CorinthiansCorinthians | 1 - 1 | América de CaliAmérica de Ca |
| 07 May 25 | r04 | MelgarMelgar | 0 - 1 | LanúsLanús |
| 07 May 25 | r04 | Cerro LargoCerro Largo | 1 - 3 | Universidad Católica del Universidad C |
| 07 May 25 | r04 | UniónUnión | 1 - 2 | PalestinoPalestino |
| 07 May 25 | r04 | Academia Puerto CabelloAcademia Puer | 4 - 1 | Vasco da GamaVasco da Gama |
| 08 May 25 | r04 | Atlético GrauAtlético Grau | 0 - 0 | GrêmioGrêmio |
| 08 May 25 | r04 | Mushuc RunaMushuc Runa | 1 - 1 | CruzeiroCruzeiro |
| 08 May 25 | r04 | Once CaldasOnce Caldas | 1 - 0 | Unión EspañolaUnión Español |
| 08 May 25 | r04 | Racing MontevideoRacing Montev | 1 - 3 | HuracánHuracán |
| 08 May 25 | r04 | Deportes IquiqueDeportes Iqui | 3 - 2 | Atlético MineiroAtlético Mine |
| 09 May 25 | r04 | GV San JoséGV San José | 1 - 0 | FluminenseFluminense |
| 09 May 25 | r04 | CiencianoCienciano | 3 - 1 | CaracasCaracas |
| |
| 13 May 25 | r05 | Nacional PotosíNacional Poto | 3 - 0 | Boston RiverBoston River |
| 13 May 25 | r05 | GrêmioGrêmio | 1 - 1 | Godoy CruzGodoy Cruz |
| 14 May 25 | r05 | UniónUnión | 0 - 1 | Mushuc RunaMushuc Runa |
| 14 May 25 | r05 | LanúsLanús | 1 - 0 | Vasco da GamaVasco da Gama |
| 14 May 25 | r05 | Academia Puerto CabelloAcademia Puer | 0 - 1 | MelgarMelgar |
| 14 May 25 | r05 | Defensa y JusticiaDefensa y Jus | 1 - 1 | Universidad Católica del Universidad C |
| 14 May 25 | r05 | Sportivo LuqueñoSportivo Luqu | 1 - 1 | Atlético GrauAtlético Grau |
| 14 May 25 | r05 | FluminenseFluminense | 2 - 0 | Unión EspañolaUnión Español |
| 15 May 25 | r05 | Cerro LargoCerro Largo | 0 - 1 | VitóriaVitória |
| 15 May 25 | r05 | CruzeiroCruzeiro | 2 - 1 | PalestinoPalestino |
| 15 May 25 | r05 | América de CaliAmérica de Ca | 0 - 0 | HuracánHuracán |
| 15 May 25 | r05 | IndependienteIndependiente | 1 - 0 | Club GuaraníClub Guaraní |
| 15 May 25 | r05 | Racing MontevideoRacing Montev | 0 - 1 | CorinthiansCorinthians |
| 16 May 25 | r05 | Atlético MineiroAtlético Mine | 3 - 1 | CaracasCaracas |
| 16 May 25 | r05 | Once CaldasOnce Caldas | 2 - 1 | GV San JoséGV San José |
| 16 May 25 | r05 | CiencianoCienciano | 4 - 0 | Deportes IquiqueDeportes Iqui |
| |
| 27 May 25 | r06 | LanúsLanús | 2 - 2 | Academia Puerto CabelloAcademia Puer |
| 27 May 25 | r06 | Vasco da GamaVasco da Gama | 3 - 0 | MelgarMelgar |
| 28 May 25 | r06 | América de CaliAmérica de Ca | 1 - 1 | Racing MontevideoRacing Montev |
| 28 May 25 | r06 | HuracánHuracán | 1 - 0 | CorinthiansCorinthians |
| 28 May 25 | r06 | IndependienteIndependiente | 7 - 0 | Nacional PotosíNacional Poto |
| 28 May 25 | r06 | Club GuaraníClub Guaraní | 0 - 5 | Boston RiverBoston River |
| 29 May 25 | r06 | Defensa y JusticiaDefensa y Jus | 1 - 2 | Cerro LargoCerro Largo |
| 29 May 25 | r06 | Universidad Católica del Universidad C | 1 - 0 | VitóriaVitória |
| 29 May 25 | r06 | CruzeiroCruzeiro | 0 - 0 | UniónUnión |
| 29 May 25 | r06 | PalestinoPalestino | 0 - 2 | Mushuc RunaMushuc Runa |
| 29 May 25 | r06 | GrêmioGrêmio | 1 - 0 | Sportivo LuqueñoSportivo Luqu |
| 29 May 25 | r06 | Godoy CruzGodoy Cruz | 2 - 2 | Atlético GrauAtlético Grau |
| 30 May 25 | r06 | FluminenseFluminense | 2 - 0 | Once CaldasOnce Caldas |
| 30 May 25 | r06 | Unión EspañolaUnión Español | 4 - 0 | GV San JoséGV San José |
| 30 May 25 | r06 | Atlético MineiroAtlético Mine | 1 - 1 | CiencianoCienciano |
| 30 May 25 | r06 | CaracasCaracas | 2 - 1 | Deportes IquiqueDeportes Iqui |
| |
| 15 Jul 25 | Playoff | Central Córdoba de SantiaCentral Córdo | 0 - 0 | Cerro LargoCerro Largo |
| 16 Jul 25 | Playoff | BahiaBahia | 0 - 0 | América de CaliAmérica de Ca |
| 16 Jul 25 | Playoff | Independiente del ValleIndependiente | 4 - 0 | Vasco da GamaVasco da Gama |
| 16 Jul 25 | Playoff | BolívarBolívar | 3 - 0 | PalestinoPalestino |
| 17 Jul 25 | Playoff | Alianza LimaAlianza Lima | 2 - 0 | GrêmioGrêmio |
| 17 Jul 25 | Playoff | San Antonio Bulo BuloSan Antonio B | 0 - 3 | Once CaldasOnce Caldas |
| 17 Jul 25 | Playoff | Universidad de ChileUniversidad d | 5 - 0 | Club GuaraníClub Guaraní |
| 18 Jul 25 | Playoff | Atlético BucaramangaAtlético Buca | 0 - 1 | Atlético MineiroAtlético Mine |
| 22 Jul 25 | Playoff | Cerro LargoCerro Largo | 0 - 3 | Central Córdoba de SantiaCentral Córdo |
| 23 Jul 25 | Playoff | América de CaliAmérica de Ca | 2 - 0 | BahiaBahia |
| 23 Jul 25 | Playoff | Vasco da GamaVasco da Gama | 1 - 1 | Independiente del ValleIndependiente |
| 23 Jul 25 | Playoff | PalestinoPalestino | 0 - 3 | BolívarBolívar |
| 24 Jul 25 | Playoff | GrêmioGrêmio | 1 - 1 | Alianza LimaAlianza Lima |
| 24 Jul 25 | Playoff | Once CaldasOnce Caldas | 4 - 0 | San Antonio Bulo BuloSan Antonio B |
| 24 Jul 25 | Playoff | Club GuaraníClub Guaraní | 2 - 1 | Universidad de ChileUniversidad d |
| 25 Jul 25 | Playoff | Atlético MineiroAtlético Mine | 0 - 1 | Atlético BucaramangaAtlético Buca |
| |
| 12 Aug 25 | r16 | Once CaldasOnce Caldas | 1 - 0 | HuracánHuracán |
| 13 Aug 25 | r16 | Independiente del ValleIndependiente | 1 - 0 | Mushuc RunaMushuc Runa |
| 13 Aug 25 | r16 | América de CaliAmérica de Ca | 1 - 2 | FluminenseFluminense |
| 13 Aug 25 | r16 | BolívarBolívar | 2 - 0 | CiencianoCienciano |
| 14 Aug 25 | r16 | Universidad de ChileUniversidad d | 1 - 0 | IndependienteIndependiente |
| 14 Aug 25 | r16 | Alianza LimaAlianza Lima | 2 - 0 | Universidad Católica del Universidad C |
| 14 Aug 25 | r16 | Atlético MineiroAtlético Mine | 2 - 1 | Godoy CruzGodoy Cruz |
| 15 Aug 25 | r16 | Central Córdoba de SantiaCentral Córdo | 1 - 0 | LanúsLanús |
| 19 Aug 25 | r16 | HuracánHuracán | 1 - 3 | Once CaldasOnce Caldas |
| 20 Aug 25 | r16 | FluminenseFluminense | 2 - 0 | América de CaliAmérica de Ca |
| 20 Aug 25 | r16 | Mushuc RunaMushuc Runa | 2 - 1 | Independiente del ValleIndependiente |
| 20 Aug 25 | r16 | CiencianoCienciano | 0 - 2 | BolívarBolívar |
| 21 Aug 25 | r16 | Universidad Católica del Universidad C | 1 - 2 | Alianza LimaAlianza Lima |
| 21 Aug 25 | r16 | IndependienteIndependiente | 1 - 1 | Universidad de ChileUniversidad d |
| 21 Aug 25 | r16 | Godoy CruzGodoy Cruz | 0 - 1 | Atlético MineiroAtlético Mine |
| 22 Aug 25 | r16 | LanúsLanús | 1 - 0 | Central Córdoba de SantiaCentral Córdo |
| |
| 17 Sep 25 | QF | LanúsLanús | 1 - 0 | FluminenseFluminense |
| 17 Sep 25 | QF | BolívarBolívar | 2 - 2 | Atlético MineiroAtlético Mine |
| 18 Sep 25 | QF | Independiente del ValleIndependiente | 0 - 2 | Once CaldasOnce Caldas |
| 19 Sep 25 | QF | Alianza LimaAlianza Lima | 0 - 0 | Universidad de ChileUniversidad d |
| 24 Sep 25 | QF | FluminenseFluminense | 1 - 1 | LanúsLanús |
| 24 Sep 25 | QF | Atlético MineiroAtlético Mine | 1 - 0 | BolívarBolívar |
| 25 Sep 25 | QF | Once CaldasOnce Caldas | 0 - 2 | Independiente del ValleIndependiente |
| 26 Sep 25 | QF | Universidad de ChileUniversidad d | 2 - 1 | Alianza LimaAlianza Lima |
| |
| 22 Oct 25 | SF | Independiente del ValleIndependiente | 1 - 1 | Atlético MineiroAtlético Mine |
| 23 Oct 25 | SF | Universidad de ChileUniversidad d | 2 - 2 | LanúsLanús |
| 29 Oct 25 | SF | Atlético MineiroAtlético Mine | 3 - 1 | Independiente del ValleIndependiente |
| 30 Oct 25 | SF | LanúsLanús | 1 - 0 | Universidad de ChileUniversidad d |
| |
| 22 Nov 25 | Final | LanúsLanús | 0 - 0 | Atlético MineiroAtlético Mine |
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