| 27 Apr 21 | r02     | BahiaBahia | 5 - 0 | Club Deportivo GuabiráClub Deportiv |
| 28 Apr 21 | r02 | HuachipatoHuachipato | 0 - 0 | 12 de Octubre12 de Octubre |
| 28 Apr 21 | r02 | Arsenal SarandiArsenal Saran | 0 - 0 | CearaCeara |
| 28 Apr 21 | r02 | IndependienteIndependiente | 3 - 1 | Montevideo City TorqueMontevideo Ci |
| 28 Apr 21 | r02 | Atletico PRAtletico PR | 1 - 0 | Metropolitanos F.C.Metropolitano |
| 29 Apr 21 | r02 | Rosario CentralRosario Centr | 2 - 0 | San LorenzoSan Lorenzo |
| 29 Apr 21 | r02 | FBC MelgarFBC Melgar | 2 - 0 | SD AucasSD Aucas |
| 29 Apr 21 | r02 | Deportes TolimaDeportes Toli | 1 - 1 | Talleres de CordobaTalleres de C |
| 29 Apr 21 | r02 | EmelecEmelec | 3 - 0 | BragantinoBragantino |
| 29 Apr 21 | r02 | WilstermannWilstermann | 0 - 0 | BolivarBolivar |
| 29 Apr 21 | r02 | Sport HuancayoSport Huancay | 1 - 2 | Club River Plate AsunciónClub River Pl |
| 29 Apr 21 | r02 | CorinthiansCorinthians | 0 - 2 | PeñarolPeñarol |
| 30 Apr 21 | r02 | PalestinoPalestino | 0 - 1 | Atletico GOAtletico GO |
| 30 Apr 21 | r02 | Newells Old BoysNewells Old B | 1 - 3 | Club LibertadClub Libertad |
| 30 Apr 21 | r02 | La EquidadLa Equidad | 2 - 1 | Aragua F.C.Aragua F.C. |
| 30 Apr 21 | r02 | LanusLanus | 1 - 2 | GremioGremio |
Team 2021 Schedules
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