| 13 Jul 21 | r16     | LDU QuitoLDU Quito | 0 - 1 | GremioGremio |
| 14 Jul 21 | r16 | América de CaliAmérica de Ca | 0 - 1 | Atletico PRAtletico PR |
| 14 Jul 21 | r16 | Sporting CristalSporting Cris | 2 - 1 | Arsenal SarandiArsenal Saran |
| 15 Jul 21 | r16 | Atlético JuniorAtlético Juni | 3 - 4 | Club LibertadClub Libertad |
| 15 Jul 21 | r16 | Independiente del ValleIndependiente | 0 - 2 | BragantinoBragantino |
| 15 Jul 21 | r16 | Santos FCSantos FC | 1 - 0 | IndependienteIndependiente |
| 16 Jul 21 | r16 | Nacional MontevideoNacional Mont | 1 - 2 | PeñarolPeñarol |
| 16 Jul 21 | r16 | Deportivo Táchira F.C.Deportivo Tác | 2 - 2 | Rosario CentralRosario Centr |
| 20 Jul 21 | r16 | GremioGremio | 1 - 2 | LDU QuitoLDU Quito |
| 21 Jul 21 | r16 | Atletico PRAtletico PR | 4 - 1 | América de CaliAmérica de Ca |
| 21 Jul 21 | r16 | Arsenal SarandiArsenal Saran | 1 - 1 | Sporting CristalSporting Cris |
| 22 Jul 21 | r16 | BragantinoBragantino | 1 - 1 | Independiente del ValleIndependiente |
| 22 Jul 21 | r16 | Club LibertadClub Libertad | 0 - 1 | Atlético JuniorAtlético Juni |
| 22 Jul 21 | r16 | IndependienteIndependiente | 1 - 1 | Santos FCSantos FC |
| 23 Jul 21 | r16 | PeñarolPeñarol | 0 - 1 | Nacional MontevideoNacional Mont |
| 23 Jul 21 | r16 | Rosario CentralRosario Centr | 1 - 0 | Deportivo Táchira F.C.Deportivo Tác |
Team 2021 Schedules
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