| 18 May 21 | r05     | IndependienteIndependiente | 1 - 0 | BahiaBahia |
| 18 May 21 | r05 | Club River Plate AsunciónClub River Pl | 2 - 1 | PeñarolPeñarol |
| 19 May 21 | r05 | Talleres de CordobaTalleres de C | 0 - 1 | BragantinoBragantino |
| 19 May 21 | r05 | WilstermannWilstermann | 1 - 2 | Arsenal SarandiArsenal Saran |
| 19 May 21 | r05 | Atletico GOAtletico GO | 0 - 0 | Club LibertadClub Libertad |
| 19 May 21 | r05 | EmelecEmelec | 2 - 0 | Deportes TolimaDeportes Toli |
| 20 May 21 | r05 | Rosario CentralRosario Centr | 5 - 0 | HuachipatoHuachipato |
| 20 May 21 | r05 | Atletico PRAtletico PR | 1 - 0 | FBC MelgarFBC Melgar |
| 20 May 21 | r05 | SD AucasSD Aucas | 3 - 0 | Metropolitanos F.C.Metropolitano |
| 20 May 21 | r05 | 12 de Octubre12 de Octubre | 0 - 2 | San LorenzoSan Lorenzo |
| 20 May 21 | r05 | CearaCeara | 2 - 0 | BolivarBolivar |
| 20 May 21 | r05 | Newells Old BoysNewells Old B | 3 - 1 | PalestinoPalestino |
| 21 May 21 | r05 | Club Deportivo GuabiráClub Deportiv | 0 - 4 | Montevideo City TorqueMontevideo Ci |
| 21 May 21 | r05 | CorinthiansCorinthians | 5 - 0 | Sport HuancayoSport Huancay |
| 21 May 21 | r05 | LanusLanus | 4 - 1 | La EquidadLa Equidad |
| 21 May 21 | r05 | Aragua F.C.Aragua F.C. | 2 - 6 | GremioGremio |
Team 2021 Schedules
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